DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mdr49 and Tap1

DIOPT Version :9

Sequence 1:NP_523724.2 Gene:Mdr49 / 36428 FlyBaseID:FBgn0004512 Length:1302 Species:Drosophila melanogaster
Sequence 2:NP_114444.2 Gene:Tap1 / 24811 RGDID:3817 Length:725 Species:Rattus norvegicus


Alignment Length:619 Identity:190/619 - (30%)
Similarity:311/619 - (50%) Gaps:94/619 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 LLVVSLLVATAASAFIPYFMIIYGEFTS-LLVDRTVGVGTSSPAFALPMFGGGQQLTNASKEENN 108
            |::|.|:::......||:|.   |..|. :|.|:|      :|:||..|:               
  Rat   166 LVLVLLILSCLGEMAIPFFT---GRITDWILQDKT------APSFARNMW--------------- 206

  Fly   109 QAIIDDATAFGIGSLVGSVAMFLLITLAIDLAN----RIALNQI-DRIRKLFLEAMLRQDIAWYD 168
                             .:.:..:.:.|::.|.    .|.:..: .|:......|:|.|:..::.
  Rat   207 -----------------LMCILTVASTALEFAGDGIYNITMGHMHSRVHGEVFRAVLHQETGFFL 254

  Fly   169 TSSGSNFASKMTEDLDKLKEGIGEKIVIVVFLIMTFVIGIVSAFVYG-WKLTLVVLSCVPFIIAA 232
            .:...:..|::|||...:.|.|.:|:.:.::.:...:. :::..::| :.||:|.|..:|.:...
  Rat   255 KNPTGSITSRVTEDTSNVCESISDKLNLFLWYLGRGLC-LLAFMIWGSFYLTVVTLLSLPLLFLL 318

  Fly   233 TSVVARLQGSLAEKELKSYSDAANVVEEVFSGIRTVFAFSGQEKEKERFGKLLIPAENTGRKKGL 297
            ...:.::..|||.|..:|.:.:..|..|..|.:.||.:|:.:|.|.::|.:.|...:...:|:.|
  Rat   319 PRRLGKVYQSLAVKVQESLAKSTQVALEALSAMPTVRSFANEEGEAQKFRQKLEEMKPLNKKEAL 383

  Fly   298 --------YSGMGNALSWLIIYLCMAL----AIWYG--VTLILDERDLPDRVYTPAVLVIVLFAV 348
                    .|..|..|...|:||...|    |:..|  |:.:|.:..     :|.|  |.||.::
  Rat   384 AYVTEVWTMSVSGMLLKVGILYLGGQLVVRGAVSSGNLVSFVLYQLQ-----FTRA--VEVLLSI 441

  Fly   349 IMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMDEKGN-RPENTAGHIRFEGIRFRYP 412
            ....|.             :..|.:.:|..:|| :...|:  .|: .|.|..|.::|:.:.|.||
  Rat   442 YPSMQK-------------SVGASEKIFEYLDR-TPCSPL--SGSLAPLNMKGLVKFQDVSFAYP 490

  Fly   413 ARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRFYDPEAGSVKLDGRDLRTLNVGWLR 477
            ..|:|::|:|||..:.||:..|.||.:|.||||:..|:|..|.|..|.|.|||..|...:..:|.
  Rat   491 NHPNVQVLQGLTFTLYPGKVTALVGPNGSGKSTVAALLQNLYQPTGGKVLLDGELLVQYDHHYLH 555

  Fly   478 SQIGVVGQEPVLFATTIGENIRYG-RPSATQADIEKAARAANCHDFITRLPKGYDTQVGEKGAQI 541
            :|:..|||||:||..:..|||.|| ..:.|..:|...|..:..||||:..|:||||:|||.|.|:
  Rat   556 TQVAAVGQEPLLFGRSFRENIAYGLTRTPTMEEITAVAMESGAHDFISGFPQGYDTEVGETGNQL 620

  Fly   542 SGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSAL----ELASQGPTTLVVAHRLSTI 602
            ||||:|.:|:||||:|:|::|:||:||||||..::.|||..|    |.||:  |.|::..:||..
  Rat   621 SGGQRQAVALARALIRKPRLLILDDATSALDAGNQLRVQRLLYESPEWASR--TVLLITQQLSLA 683

  Fly   603 TNADKIVFLKDGVVAEQGTHEELMERRGLYCELV 636
            ..|..|:|||:|.|.|||||.:||||.|.|..:|
  Rat   684 ERAHHILFLKEGSVCEQGTHLQLMERGGCYRSMV 717

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mdr49NP_523724.2 MdlB 34..640 CDD:224055 190/619 (31%)
ABC_membrane 116..352 CDD:279056 53/255 (21%)
ABC_MTABC3_MDL1_MDL2 402..636 CDD:213216 111/238 (47%)
MdlB 735..1299 CDD:224055
ABC_membrane 739..998 CDD:279056
ABC_MTABC3_MDL1_MDL2 1059..1298 CDD:213216
Tap1NP_114444.2 3a01208 2..717 CDD:273363 189/617 (31%)
ABC_membrane 177..435 CDD:279056 62/306 (20%)
Part of the peptide-binding site. /evidence=ECO:0000250|UniProtKB:Q03518 352..397 10/44 (23%)
Part of the peptide-binding site. /evidence=ECO:0000250|UniProtKB:Q03518 430..464 10/54 (19%)
P-loop_NTPase 469..697 CDD:304359 103/229 (45%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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