DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mdr49 and Abcb1b

DIOPT Version :9

Sequence 1:NP_523724.2 Gene:Mdr49 / 36428 FlyBaseID:FBgn0004512 Length:1302 Species:Drosophila melanogaster
Sequence 2:NP_036755.3 Gene:Abcb1b / 24646 RGDID:3318 Length:1275 Species:Rattus norvegicus


Alignment Length:1314 Identity:544/1314 - (41%)
Similarity:794/1314 - (60%) Gaps:91/1314 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 KKEESRLPQAGDFQLKEGSVVDATRKYSYFDLFRYSTRCERFLLVVSLLVATAASAFIPYFMIIY 67
            |||:.:.|..|                 .|.:|||:...::..:.:..|.|......:|..|:::
  Rat    23 KKEKEKKPAVG-----------------IFGMFRYADWLDKLCMALGTLAAIIHGTLLPLLMLVF 70

  Fly    68 GEFTSLLVDRTVGVGTSSPAFALPMFGGGQQLTNASKEENNQAIIDDA------------TAFGI 120
            |..|...        |.:....||      .:||.|:..:.|.:.|.:            |..|.
  Rat    71 GYMTDSF--------TQAETRILP------SVTNQSEINSTQTVSDSSLEEDMAMYAYYYTGIGA 121

  Fly   121 GSLVGSVAMFLLITLAIDLANRIALNQIDRIRKLFLEAMLRQDIAWYDTSSGSNFASKMTEDLDK 185
            |.|:.:.....|..||       |..||.:||:.|..|::.|:|.|:|.:......:::|:|:.|
  Rat   122 GVLIVAYIQVSLWCLA-------AGRQIHKIRQKFFHAIMNQEIGWFDVNDAGELNTRLTDDVSK 179

  Fly   186 LKEGIGEKIVIVVFLIMTFVIGIVSAFVYGWKLTLVVLSCVPFIIAATSVVARLQGSLAEKELKS 250
            :.:|||:|:.:....|.||..|.:..|:.|||||||:|:..|.|..::::.|::..|...|||::
  Rat   180 INDGIGDKLGMFFQSITTFSAGFIIGFISGWKLTLVILAVSPLIGLSSAMWAKVLTSFTNKELQA 244

  Fly   251 YSDAANVVEEVFSGIRTVFAFSGQEKEKERFGKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMA 315
            |:.|..|.|||.:.||||.||.||:||.||:.|.|..|:..|.||.:.:.:...:::|::|...|
  Rat   245 YAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRVGIKKAITANISIGIAYLLVYASYA 309

  Fly   316 LAIWYGVTLILDERDLPDRVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIID 380
            ||.|||.:|:|...      |:...::.|.|::::|..::|..:|::||.|.|..|...:|.|||
  Rat   310 LAFWYGTSLVLSNE------YSIGQVLTVFFSILLGTFSIGHLAPNIEAFANARGAAYEIFKIID 368

  Fly   381 RPSQVDPMDEKGNRPENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKST 445
            ....:|....||::|::..|::.|:.:.|.||:|.:|:|||||.:.|..|||||.||.|||||||
  Rat   369 NEPSIDSFSTKGHKPDSIMGNLEFKNVYFNYPSRSEVKILKGLNLKVKSGQTVALVGNSGCGKST 433

  Fly   446 LIQLMQRFYDPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQADI 510
            .:||:||.|||..|.|.:||:|:||:||.:||..||||.||||||||||.|||||||.:.|..:|
  Rat   434 TVQLLQRLYDPIEGEVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEI 498

  Fly   511 EKAARAANCHDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSALDPTS 575
            |||.:.||.:|||.:||..::|.|||:|||:||||||||||||||||.|::|||||||||||..|
  Rat   499 EKAVKEANAYDFIMKLPHKFNTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTES 563

  Fly   576 EKRVQSALELASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELMERRGLYCELVSITQ 640
            |..||:||:.|.:|.||:|:||||||:.|||.|.....||:.|||.|||||:.:|:|.:|| :||
  Rat   564 EAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHEELMKEKGIYFKLV-MTQ 627

  Fly   641 RKEATEADEGAVAGRPLQKSQNL--SDEETDDDEEDEEEDEEPELQTSGSSRDSGFRASTRRKRR 703
            .:           |..::...|.  |..:|...|...|:.:.|.::.|       .|.|..|::.
  Rat   628 TR-----------GNEIEPGNNAYESQSDTGASELTSEKSKSPLIRRS-------IRRSIHRRQD 674

  Fly   704 SQRRKKKKD--KEVVSKVSFTQLMKLNSPEWRFIVVGGIASVMHGATFPLWGLFFGDFFGILSDG 766
            .:||...|:  .|.|..|||.|::|||..||.::|||.:.:|::|...|::.:.|....|:.|..
  Rat   675 QERRLSSKEDVDEDVPMVSFWQILKLNISEWPYLVVGVLCAVINGCIQPVFAIVFSKIVGVFSRD 739

  Fly   767 DDDVVRAEVLKI-SMIFVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDE 830
            ||...:.....: |::|:.:|:::.:....|.:.|..||..:|.|||...|.:::.|||::|||.
  Rat   740 DDHETKQRNCNLFSLLFLVMGMISFVTYFFQGFTFGKAGEILTKRLRYMVFKSMLRQDISWFDDH 804

  Fly   831 RNSVGALCSRLASDCSNVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTLVTLPLVCLSV 895
            :|:.|:|.:|||||.|||:||.|:|:..:.|.||.|..|:::..|:.||.|||.:|.:||:.|..
  Rat   805 KNTTGSLTTRLASDASNVKGAMGSRLAVVTQNVANLGTGIILSLVYGWQLTLLLVVIIPLIVLGG 869

  Fly   896 YLEGRFIMKSAQKAKASIEEASQVAVEAITNIRTVNGLCLERQVLDQYVQQIDRVDIACRRKVRF 960
            .:|.:.:...|.|.|..:|.:.::|.|||.|.|||..|..|::....|.|.:........:|...
  Rat   870 IIEMKLLSGQALKDKKELEISGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNALKKAHV 934

  Fly   961 RGLVFALGQAAPFLAYGISMYYGGILVAEERMNYEDIIKVAEALIFGSWMLGQALAYAPNVNDAI 1025
            .|:.||..||..:.:|.....:|..|||.|.|.:|:::.|..|::||:...|...::||:...|.
  Rat   935 FGITFAFTQAMIYFSYAACFRFGAYLVARELMTFENVMLVFSAVVFGAMAAGNTSSFAPDYAKAK 999

  Fly  1026 LSAGRLMDLFKRTSTQPNPPQSPYNTVEKS----EGDIVYENVGFEYPTRKGTPILQGLNLTIKK 1086
            :||..::.:.::.     |....|:|....    ||::.:..|.|.||||...|:||||:..:||
  Rat  1000 VSASHIIRIIEKI-----PEIDSYSTEGLKPNWLEGNVKFNGVMFNYPTRPNIPVLQGLSFEVKK 1059

  Fly  1087 STTVALVGPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTI 1151
            ..|:||||.||.||||.||||.|:|:|::|:|.|.|....:..:..||:.||:|||||:|||.:|
  Rat  1060 GQTLALVGSSGCGKSTVVQLLERFYNPMAGTVFLDGKEIKQLNVQWLRAHLGIVSQEPILFDCSI 1124

  Fly  1152 AENIAYGNNFRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRLG-KTSQLSGGQKQRIAIARALV 1215
            .||||||:|.| .||.:||:.||:::|||.||.:||:.|:||:| |.:|||||||||||||||||
  Rat  1125 TENIAYGDNSR-VVSHEEIVRAAREANIHQFIDSLPEKYNTRVGDKGTQLSGGQKQRIAIARALV 1188

  Fly  1216 RNPKILILDEATSALDLESEKVVQQALDEARSGRTCLTIAHRLTTVRNADLICVLKRGVVVEHGT 1280
            |.|.||:|||||||||.|||||||:|||:||.||||:.|||||:|::|||||.|::.|.|.||||
  Rat  1189 RQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGQVKEHGT 1253

  Fly  1281 HDELMALNKIYANL 1294
            |.:|:|...||.::
  Rat  1254 HQQLLAQKGIYFSM 1267

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mdr49NP_523724.2 MdlB 34..640 CDD:224055 263/617 (43%)
ABC_membrane 116..352 CDD:279056 82/235 (35%)
ABC_MTABC3_MDL1_MDL2 402..636 CDD:213216 145/233 (62%)
MdlB 735..1299 CDD:224055 248/566 (44%)
ABC_membrane 739..998 CDD:279056 87/259 (34%)
ABC_MTABC3_MDL1_MDL2 1059..1298 CDD:213216 143/237 (60%)
Abcb1bNP_036755.3 PTZ00265 54..1269 CDD:240339 535/1266 (42%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 207 1.000 Domainoid score I2784
eggNOG 1 0.900 - - E2759_KOG0055
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H69084
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG63700
OrthoDB 1 1.010 - - D186078at2759
OrthoFinder 1 1.000 - - FOG0000106
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100059
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X92
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
109.730

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