Protein Alignment Mdr49 and Abcc1

DIOPT Version :9

• Sequence 1: NP_523724.2
• Gene: Mdr49 / 36428
• FlyBaseID: FBgn0004512
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_071617.2
• Gene: Abcc1 / 24565
• RGDID: 3112
• Length: 1532
• Species: Rattus norvegicus
• Alignment Length: 1416
• Identity: 323/1416 - (22%)
• Similarity: 580/1416 - (40%)
• Gaps: 299/1416 - (21%)

  Fly    13 GDFQLKEGSVVDATRKYSYFDLFRYSTRCERFLLVVSLLVATAASAFIPYFMI--IYGEFTSLLV 75
            |..||.....|:|        |...|:..:|...:..:|..|    |.|||::  :|.....|:
  Rat   288 GSSQLDVNEEVEA--------LIVKSSHKDRDPSLFKVLYKT----FGPYFLMSFLYKALHDLM- 339

  Fly    76 DRTVGVGTSSPAFALPMFGGGQQL------TNASKEENNQAIIDDATAFGIGSLVGSVAMFLLIT 134
                            ||.|.:.|      .|..:..:.|..:..|..|         ....|.|
  Rat   340 ----------------MFAGPEILELIINFVNDREAPDWQGYLYTALLF---------VSACLQT 379

  Fly   135 LAIDLANRIALNQIDRIRKLFLEAMLRQDIAWYDTSSGSN----FASKMTEDLDKLKEGIGEKIV 195
            ||:.....|......||:...:.|:.|:.:...:::..|:    ..:.|:.|..:..:     :.
  Rat   380 LALHQYFHICFVTGMRIKTAVVGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMD-----LA 439

  Fly   196 IVVFLIMTFVIGIVSAFVYGWKLTL---------VVLSCVPFIIAATSVVARLQGSLAEKELKSY 251
            ..:.:|.:..:.:..|..:.| |.|         |::..|||    .:|:|....:.....:||.
  Rat   440 TYINMIWSAPLQVTLALYFLW-LNLGPSVLAGVAVMILMVPF----NAVMAMKTKTYQVAHMKSK 499

  Fly   252 SDAANVVEEVFSGIRTV------FAFSGQEK----EKERFGKLLIPAENTGRKKGLYSGMGNALS 306
            .:...::.|:.:||:.:      .||  |:|    .:|.. |:|        ||..|.......:
  Rat   500 DNRIKLMNEILNGIKVLKLYAWELAF--QDKVMNIRQEEL-KVL--------KKSAYLAAVGTFT 553

  Fly   307 WLIIYLCMALAIWYGVTLILDERDLPDRVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAA 371
            |:.....:||:. :.|.:.:||:::.|.  ..|.:.:.||.::....|:   .|.|.:..|..:.
  Rat   554 WVCTPFLVALST-FAVFVTVDEKNILDA--KKAFVSLALFNILRFPLNI---LPMVISSIVQASV 612

  Fly   372 GQTLFNIIDRPSQVDP--MDEKGNRPENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVA 434
            ......|.....:::|  ::....:.......|..:...|.: ||.:...|.|:|..:..|..||
  Rat   613 SLKRLRIFLSHEELEPDSIERWSIKDGGGMNSITVKNATFTW-ARDEPPTLNGITFAIPDGALVA 676

  Fly   435 FVGASGCGKSTLIQLMQRFYDPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIR 499
            .||..|||||:|:..:....|...|.|.|.|             .:..|.|:..:...::.|||.
  Rat   677 VVGQVGCGKSSLLSALLAEMDKVEGHVTLKG-------------SVAYVPQQAWIQNDSLRENIL 728

  Fly   500 YGRP---SATQADIEKAARAANCHDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQV 561
            :|||   ...:|.:|..|...:    :..||.|..|::||||..:|||||||:::|||:.....:
  Rat   729 FGRPLQEHCYKAVMEACALLPD----LEILPSGDLTEIGEKGVNLSGGQKQRVSLARAVYCNSDI 789

  Fly   562 LLLDEATSALDPTSEKRVQSALELASQGP-------TTLVVAHRLSTITNADKIVFLKDGVVAEQ 619
            .|||:..||:|....|.:...:    .||       |.::|.|.:|.:...|.|:.:..|.::|.
  Rat   790 YLLDDPLSAVDAHVGKHIFEKV----VGPMGLLKNKTRILVTHGISYLPQVDVIIVMSGGKISEM 850

  Fly   620 GTHEELMERRGLYCELV---SITQRKEATEAD---------------EGAV-----AGRPLQKSQ 661
            |:::||::|.|.:.|.|   :.|::..|:|.|               |..:     .|:|||:
  Rat   851 GSYQELLDRDGAFAEFVRTYANTEQDLASEDDSKNGVSGLGKESKPVENGILVTDAVGKPLQR-- 913

  Fly   662 NLSDEETDDDEEDEEEDEEPELQTSGSSRDSGFRASTRRKRRSQRRKKKKDKEVVSKVSFTQLMK 726
            :||:..:.....:::.....|||.||...::.             :..:.||....:|..
  Rat   914 HLSNSSSHSVVTNQQHSSTAELQKSGVKEETW-------------KLMEADKAQTGQVKL----- 960

  Fly   727 LNSPEWRFIVVGGIASVMHGATFPLWGLFFGDFFGILSDG------DDDVVRAEV--------LK 777
              |..|.::...|:.     .:|....||..:....|:..      .||  |..|        .:
  Rat   961 --SVYWNYMKAIGLC-----ISFLSIFLFLCNHVSALASNYWLSLWTDD--RPAVNGTQENRNFR 1016

  Fly   778 ISMIFVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERNSVGALCSRLA 842
            :| ::..:|::.|:.....:...:..|:..:.||.......::...:::|  ||...|.|.:|.:
  Rat  1017 LS-VYGALGILQGVAVFGYSMAVSIGGIFASRRLHLDLLQNVLRSPMSFF--ERTPSGNLVNRFS 1078

  Fly   843 SDCSNVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMKSAQ 907
            .:...|.... .:|..|.......|:|.|:..:.:   |.:..|.:|.:.|..:...||.:.|::
  Rat  1079 KELDTVDSMI-PQVIKMFMGSLFSVIGAVIIILLA---TPIAAVIIPPLGLVYFFVQRFYVASSR 1139

  Fly   908 KAKASIEEASQVAVEAITNIRTVNGLCLERQVLDQ--YVQQID-RVD---------IACRRKVRF 960
            :.| .:|..|:..|.:..| .|:.|:.:.|...:|  :::|.| :||         |...|.:..
  Rat  1140 QLK-RLESVSRSPVYSHFN-ETLLGVSVIRAFEEQERFIRQSDLKVDENQKAYYPSIVANRWLAV 1202

  Fly   961 R-----------GLVFAL--------GQAAPFLAYG--ISMYYGGI----------LVAEERM-N 993
            |           ..:||:        |.....::|.  |:.|...:          :||.||: .
  Rat  1203 RLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQITAYLNWLVRMSSEMETNIVAVERLKE 1267

  Fly   994 YEDIIKVAEALIFGSWMLGQALAYAPNVNDAILSAGRLMDLFKRTSTQPNPPQSPYNTVEKSEGD 1058
            |.:..|.|      ||.:.:.   ||                  .||.|:            .|.
  Rat  1268 YSETEKEA------SWQIQET---AP------------------PSTWPH------------SGR 1293

  Fly  1059 IVYENVGFEYPTRKGTP-ILQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDPVSGSVNLSG 1122
            :.:.:....|  |:... :|:.:|:||:....|.:||.:|:|||:....|.|..:...|.:.:.|
  Rat  1294 VEFRDYCLRY--REDLDLVLKHINVTIEGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDG 1356

  Fly  1123 VPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNIHNFISALP 1187
            :...:..|..||.|:.::.|:||||..::..|:...:.:.|    :|:..|.:.:::..|:||||
  Rat  1357 INIAKIGLHNLRFKITIIPQDPVLFSGSLRMNLDPFSQYSD----EEVWMALELAHLKGFVSALP 1417

  Fly  1188 QGYDTRLGKTSQ-LSGGQKQRIAIARALVRNPKILILDEATSALDLESEKVVQQALDEARSGRTC 1251
            ...:....:..: ||.||:|.:.:||||:|..|||:|||||:|:|||::.::|..:.......|.
  Rat  1418 DKLNHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDSTV 1482

  Fly  1252 LTIAHRLTTVRNADLICVLKRGVVVEHGTHDELMALNKIYANLYLMQQVSG 1302
            |||||||.|:.:...:.||.:|.:.|.|...||:....::   |.|.:.:|
  Rat  1483 LTIAHRLNTIMDYTRVIVLDKGEIRECGAPSELLQQRGVF---YSMAKDAG 1530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	34..640	CDD:224055	149/651 (23%)
		ABC_membrane	116..352	CDD:279056	49/258 (19%)
		ABC_MTABC3_MDL1_MDL2	402..636	CDD:213216	75/243 (31%)
		MdlB	735..1299	CDD:224055	147/623 (24%)
		ABC_membrane	739..998	CDD:279056	61/316 (19%)
		ABC_MTABC3_MDL1_MDL2	1059..1298	CDD:213216	75/240 (31%)
Abcc1	NP_071617.2	MRP_assoc_pro	7..1531	CDD:188098	323/1416 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000