DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr49 and ABCB10

DIOPT Version :9

Sequence 1:	NP_523724.2	Gene:	Mdr49 / 36428	FlyBaseID:	FBgn0004512	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_036221.2	Gene:	ABCB10 / 23456	HGNCID:	41	Length:	738	Species:	Homo sapiens

Alignment Length:	602	Identity:	219/602 - (36%)
Similarity:	333/602 - (55%)	Gaps:	61/602 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   723 QLMKLNSPEWR-------FIVVGGIASVMHGATFPLWGLFFGDFFGIL-----SDGDDDVVRAEV 775
            :|:.|..||.|       |:.:..:.|:  .|.|     |.|....::     .|..|::.|. .
Human   159 KLLGLAYPERRRLAAAVGFLTMSSVISM--SAPF-----FLGKIIDVIYTNPTVDYSDNLTRL-C 215

  Fly   776 LKISMIFVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERNSVGALCSR 840
            |.:|.:|    |.....|.::.|:..|:|.::..|||...|.:|:.|::|:||..|  .|.|.:|
Human   216 LGLSAVF----LCGAAANAIRVYLMQTSGQRIVNRLRTSLFSSILRQEVAFFDKTR--TGELINR 274

  Fly   841 LASDCSNVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMKS 905
            |:||.:.:..:....:...|:|.|...||:.:.|..|.......|..:|.|.:...:.||::.|.
Human   275 LSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKL 339

  Fly   906 AQKAKASIEEASQVAVEAITNIRTVNGLCLERQVLDQYVQQIDRVDIACRRKVRFRGLVFALGQA 970
            .:..:.|:.:|:|:|.|.|.|:|||.....|...:::|..::|.|....|::        |..:|
Human   340 TKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKE--------AFARA 396

  Fly   971 APFLAYGIS--------MYYGGILVAEERMNYEDIIKVAEALIFGSWM---LGQALAYAPNVNDA 1024
            ..|.|.|:|        :|.||:|:....|.   :.:::..|::..|:   :|...::...:...
Human   397 GFFGATGLSGNLIVLSVLYKGGLLMGSAHMT---VGELSSFLMYAFWVGISIGGLSSFYSELMKG 458

  Fly  1025 ILSAGRLMDLFKRTSTQPNPPQSPYN----TVEKS-EGDIVYENVGFEYPTRKGTPILQGLNLTI 1084
            :.:.|||.:|.:|      .|:.|:|    ..||| :|.:.::||.|.||.|...||.|..:|:|
Human   459 LGAGGRLWELLER------EPKLPFNEGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSI 517

  Fly  1085 KKSTTVALVGPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFDR 1149
            ...:..||||||||||||.:.||||.|||.||:::|.|....:.....||||:|.|||||:||..
Human   518 PSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSC 582

  Fly  1150 TIAENIAYGNNFRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRLG-KTSQLSGGQKQRIAIARA 1213
            :||||||||.:....|:.:||...|:.:|...||...|||::|.:| |...||||||||||||||
Human   583 SIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARA 647

  Fly  1214 LVRNPKILILDEATSALDLESEKVVQQALDEARSGRTCLTIAHRLTTVRNADLICVLKRGVVVEH 1278
            |::|||||:|||||||||.|:|.:||:|||....|||.|.|||||:|::||:::.||.:|.:.|:
Human   648 LLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEY 712

  Fly  1279 GTHDELMAL-NKIYANL 1294
            |.|:||::. |.||..|
Human   713 GKHEELLSKPNGIYRKL 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	34..640	CDD:224055
		ABC_membrane	116..352	CDD:279056
		ABC_MTABC3_MDL1_MDL2	402..636	CDD:213216
		MdlB	735..1299	CDD:224055	213/583 (37%)
		ABC_membrane	739..998	CDD:279056	71/271 (26%)
		ABC_MTABC3_MDL1_MDL2	1059..1298	CDD:213216	127/238 (53%)
ABCB10	NP_036221.2	mitochondrial targeting sequence	1..105
		PWWP	1..>26	CDD:295359
		MdlB	163..734	CDD:224055	218/598 (36%)
		ABC_membrane	177..438	CDD:279056	73/285 (26%)
		ABC_MTABC3_MDL1_MDL2	493..733	CDD:213216	127/237 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910