Protein Alignment Mdr49 and Abcc10

DIOPT Version :9

• Sequence 1: NP_523724.2
• Gene: Mdr49 / 36428
• FlyBaseID: FBgn0004512
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_001334325.1
• Gene: Abcc10 / 224814
• MGIID: 2386976
• Length: 1526
• Species: Mus musculus
• Alignment Length: 1392
• Identity: 319/1392 - (22%)
• Similarity: 553/1392 - (39%)
• Gaps: 355/1392 - (25%)

  Fly    86 PAFALPMFGG----GQQLTNASKEENNQAIIDDATAFGIGSLVGSVAMF---LLITLAI------ 137
            |||...:|..    |.||..|.........:    |.|:..:||::..|   ||::|.:
Mouse   257 PAFLARVFQAHWKEGAQLWRALYRAFGCCYL----ALGLLKMVGTMLGFSGPLLLSLLVGFLEEG 317

  Fly   138 -----------------DLANRIALNQID-RIRKLFLEAMLRQDIAWY----------------- 167
                             .:.:.:..||.. .:||:.|:|.:......|
Mouse   318 QEPLSHGLLYVLGLAGGTVISAVLQNQYGYEVRKVTLQARVAVLSTLYRKALKLGPSRPPTGEVL 382

  Fly   168 -----DTSSGSNFASKMTEDLDKLKEGIGEKIVIVVFLI-----MTFVIGIVSAFVYGWKLTLVV 222
                 |:....|||....|     ..|:..::.|.::|:     |.|:.|:|.|      |.||.
Mouse   383 NLLGTDSERLLNFAGSFHE-----AWGLPLQLAITLYLLYQQVGMAFLAGLVLA------LLLVP 436

  Fly   223 LSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEEVFSGIRTVFAFSGQEKEKERFGKLLIP 287
            ::.|    .||.::|..|..|..|:.:     ..::.|:.||||.:..|..::...:|     :.
Mouse   437 VNKV----IATRIMASNQEMLRHKDAR-----VKLMTELLSGIRVIKFFRWEQALGDR-----VK 487

  Fly   288 AENT---GRKKGL-YSGMGNALSW--LIIYLCMALAIWYGVTLILDERDLPDRVYTPAVLVIVLF 346
            |..|   ||.:.: |........|  |.:.:|:.:.|.|   :::..:....:|:|...||.:|
Mouse   488 ACRTKELGRLRVIKYLDAACVYLWAALPVVICITIFITY---VLMGHQLTATKVFTALALVRML- 548

  Fly   347 AVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPS-------QVDPMDEKGNRPENTAGHIRF 404
              |:...|..:.   :..:..:..:...:...:|.||       ..||
Mouse   549 --ILPLNNFPWV---INGLLESKVSLDRIQRFLDLPSYSPEAYYSPDP----------------- 591

  Fly   405 EGIRFRYPARPD--VEILKGL---------------TVDVLPGQTVAFVGASGCGKSTLIQLMQR 452
                   ||.|.  :|:.:.|               .:.|..|..|..||..|||||:|:
Mouse   592 -------PAEPSTALELHEALFSWDPIGASQKTFISHLQVKKGMLVGIVGKVGCGKSSLL----- 644

  Fly   453 FYDPEAGSVKLDGRDLRTLNVGW-----LRSQIGVVGQEPVLFATTIGENIRYGRPSATQADIEK 512
                    ..:.| :|..| .||     |....|:..|||.:...||.:||.:|:....|. ..:
Mouse   645 --------AAITG-ELHRL-CGWVAVSELSKGFGLATQEPWIQCATIRDNILFGKTFDAQL-YRE 698

  Fly   513 AARAANCHDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEK 577
            ...|...:|.::.||.|..|:|||||..:||||:.|||:|||:.::..:.|||:..:|:|.....
Mouse   699 VLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAVYQEKALYLLDDPLAAVDADVAN 763

  Fly   578 RVQSALELASQGPTT-LVVAHRLSTITNADKIVFLKDGVVAEQGTHEELMERRGLYCELVSITQR 641
            .:.....|.....|| |:..||...:..||.::.::.|.:...|...|::       .||.....
Mouse   764 HLLHRCILGVLSHTTRLLCTHRTEYLERADVVLLMEAGQLVRTGPPSEIL-------PLVQAVPT 821

  Fly   642 KEATEADEGAVAGRPLQKSQNLSDEETDDDEEDEEEDE------EPELQTSGS-----------S 689
            ..| |.::.|.:|    :|.::.|.|...:||.|.|..      :.|.::.|:           :
Mouse   822 AWA-EKEQVATSG----QSPSVCDLERTTEEELEVEQSTCGCLVQEESKSEGAVALHVYRAYWRA 881

  Fly   690 RDSGFRA----------STRR-----------KRRSQRRKKKKDKEVVSKVS---FTQLMKLNSP 730
            ..||..|          :||.           :.::.|...::|....|..|   |:..:.|.||
Mouse   882 MGSGLAAAILVSLLLMQATRNGADWWLAHWLSQLKAGRNGSREDPASCSPGSTALFSPRLLLFSP 946

  Fly   731 EWRFIVVGGIASVMHGATFPLWGLFFGDFFGILSDGDDDVVRAEVLKISMIFVGIGLMAGLGNML 795
            ...:..:  :::.:|.|.               |:|     .|:|....:::..|..:..|..:|
Mouse   947 GNLYTPL--LSTPLHKAA---------------SNG-----TADVHFYLIVYATIAGVNSLCTLL 989

  Fly   796 QTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERNSVGALCSRLASDCSNVQGATGARVGTML 860
            :..:|....::....|..|....::...:.::|...:  |.:.:|.:||.:.|..:....:..:|
Mouse   990 RAVLFAAGALQAAASLHHRLLHRLLMAPVTFYDSTPS--GRVLNRFSSDVACVDDSLPFLLNILL 1052

  Fly   861 -QAVATLVVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMKSAQKAKASIEEASQVAVEAI 924
             .:|..|.:..|:|....|  .||.|..|..|..||  :|.:        :||..|..::.....
Mouse  1053 ANSVGLLGLLAVLGSGLPW--LLLLLPPLSFVYYSV--QGYY--------RASFRELRRLGSLTW 1105

  Fly   925 TNI-----RTVNGLCLERQVLDQYVQQIDRVDIACRRKVRFRGLVFALGQAAPFLAYGISMY--- 981
            :.:     .|:.||.:.|.....|     |.:...:|       :..|.|...|.:|....:
Mouse  1106 SPLYSHLADTLAGLPVLRAAGATY-----RFEEENQR-------LLELNQRCQFASYATMQWLDI 1158

  Fly   982 ------------YGGILVAEERMNYEDIIKVAEALIFGSWMLGQALAYAPNVNDAILSAGRLMDL 1034
                        ..||.:.:.:..           :....::|..|:||.::. .:||.  |:..
Mouse  1159 RLQLMGAAVVSAIAGIALVQHQQG-----------LANPGLVGLVLSYALSLT-GLLSG--LVSS 1209

  Fly  1035 FKRTSTQP-----------NPPQSPYNTVEKS----------EGDIVYENVGFEYPTRKGTP-IL 1077
            |.:|....           :.||.|::...:|          :|.:.:::|...|  |.|.| .|
Mouse  1210 FTQTEAMMVSVERLEEYSCDVPQEPHSQPLQSPHQQRISWLTQGSVEFQDVVLVY--RPGLPNAL 1272

  Fly  1078 QGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFPLDTLRSKLGLVSQ 1142
            .|:...::....:.:||.:|||||:...:|.|..:|.:|.|.|..|.:::..|..|||:|.::.|
Mouse  1273 DGVTFRVEPGEKLGIVGRTGSGKSSLFLVLFRLLEPNAGRVLLDNVDTSQLELAELRSQLAVIPQ 1337

  Fly  1143 EPVLFDRTIAENIAYGNNFRDDVSMQEIIE---------------AAKKS-----NIHNFISA-L 1186
            ||.||..||.||:. .....:|.::.:.:|               |.::|     |.|...|| |
Mouse  1338 EPFLFSGTIRENLD-PQGLHEDRALWQALEQCHLSEVAVAMGESQACQRSQREAKNGHWQCSALL 1401

  Fly  1187 PQGYDTRLGKTSQ-LSGGQKQRIAIARALVRNPKILILDEATSALDLESEKVVQQALDEARSGRT 1250
            ..|.|..||:..| ||.||:|.:.:||||:.:.|||.:||||:::|.::::::||.:.:..:.:|
Mouse  1402 TGGLDGELGERGQNLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFANKT 1466

  Fly  1251 CLTIAHRLTTVRNADLICVLKRGVVVE 1277
            .|||||||.|:.|:|.:.||:.|.|||
Mouse  1467 VLTIAHRLNTILNSDRVLVLQAGRVVE 1493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	34..640	CDD:224055	146/647 (23%)
		ABC_membrane	116..352	CDD:279056	61/295 (21%)
		ABC_MTABC3_MDL1_MDL2	402..636	CDD:213216	69/256 (27%)
		MdlB	735..1299	CDD:224055	147/608 (24%)
		ABC_membrane	739..998	CDD:279056	48/279 (17%)
		ABC_MTABC3_MDL1_MDL2	1059..1298	CDD:213216	85/242 (35%)
Abcc10	NP_001334325.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000