Protein Alignment Mdr49 and Tap2

DIOPT Version :10

• Sequence 1: NP_523724.2
• Gene: Mdr49 / 36428
• FlyBaseID: FBgn0004512
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_035660.3
• Gene: Tap2 / 21355
• MGIID: 98484
• Length: 702
• Species: Mus musculus
• Alignment Length: 622
• Identity: 204/622 - (32%)
• Similarity: 311/622 - (50%)
• Gaps: 79/622 - (12%)

  Fly   709 KKKDKEVVSKVSFTQLMKLNSPEWRFIVVGGIASVMHGATFPLWG-----LFFGDFFGIL-SDGD 767
            ::|:....::....:|:||:.|:..|::......|:     .:||     .:.|....|| .|.|
Mouse   125 QEKEPGQENRTLMKRLLKLSRPDLPFLIAAFFFLVV-----AVWGETLIPRYSGRVIDILGGDFD 184

  Fly   768 DDVVRAEVLKISMIFVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERN 832
            .|...:.:..:.:..||....||...  .:::||.:.:.:  |:|::.|.:::.||:.:|.:.:
Mouse   185 PDAFASAIFFMCLFSVGSSFSAGCRG--GSFLFTMSRINL--RIREQLFSSLLRQDLGFFQETK- 244

  Fly   833 SVGALCSRLASDCSNVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQ-----TLLTLVTLPLVC 892
             .|.|.|||:||.|.:..........:|:::.     .|||..|...|     |.|:|:.|||..
Mouse   245 -TGELNSRLSSDTSLMSRWLPFNANILLRSLV-----KVVGLYFFMLQVSPRLTFLSLLDLPLTI 303

  Fly   893 LS--VY-LEGRFIMKSAQKAKASIEEASQVAVEAITNIRTVNGLCLERQVLDQYVQQIDRVDIAC 954
            .:  || ...:.::|..|.|   :.:|.||..||:..::||.....|.|.:..|.:.::|    |
Mouse   304 AAEKVYNPRHQAVLKEIQDA---VAKAGQVVREAVGGLQTVRSFGAEEQEVSHYKEALER----C 361

  Fly   955 RRKVRFRGL----------VFALGQAAPFLAYGISMYYGGILVAEERMNY----EDIIKVAEALI 1005
            |:....|.|          |.|||.....|..|:.....|.:.....:::    |::.:....|:
Mouse   362 RQLWWRRDLEKDVYLVIRRVMALGMQVLILNCGVQQILAGEVTRGGLLSFLLYQEEVGQYVRNLV 426

  Fly  1006 FGSWMLGQALAYAPNVNDAILSAGRLMDLFKRTSTQPNPPQSPYNTVEKSEGDIVYENVGFEYPT 1070
            :   |.|          |.:.:.|....:|.....:||.||.........||.:.:::|.|.||.
Mouse   427 Y---MYG----------DMLSNVGAAEKVFSYLDRKPNLPQPGILAPPWLEGRVEFQDVSFSYPR 478

  Fly  1071 RKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFPLDTLRS 1135
            |...|:||||..|:...|..|||||:||||||...||...|.|..|.:.|.|.|.||:....|..
Mouse   479 RPEKPVLQGLTFTLHPGTVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGEPLTEYDHHYLHR 543

  Fly  1136 KLGLVSQEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRLG-KTSQ 1199
            ::.||.||||||..::.:|||||....:|.   :::.||:.:...:||..:..|.:|.:| |..|
Mouse   544 QVVLVGQEPVLFSGSVKDNIAYGLRDCEDA---QVMAAAQAACADDFIGEMTNGINTEIGEKGGQ 605

  Fly  1200 LSGGQKQRIAIARALVRNPKILILDEATSALDLESEKVVQQALDEARS--GRTCLTIAHRLTTVR 1262
            |:.|||||:||||||||||::|||||||||||.:.|    |||...||  .||.|.|||||.||:
Mouse   606 LAVGQKQRLAIARALVRNPRVLILDEATSALDAQCE----QALQNWRSQGDRTMLVIAHRLHTVQ 666

  Fly  1263 NADLICVLKRGVVVEHGTHDELMALNKIYANLYLMQQ 1299
            |||.:.|||:|.:||   ||:|.....:||  :|:||
Mouse   667 NADQVLVLKQGRLVE---HDQLRDGQDVYA--HLVQQ 698

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	44..643	CDD:440747
		MdlB	720..1299	CDD:440747	201/609 (33%)
Tap2	NP_035660.3	3a01208	1..696	CDD:273363	201/618 (33%)
		Part of the peptide-binding site. /evidence=ECO:0000250|UniProtKB:Q03519	300..388		26/94 (28%)
		Part of the peptide-binding site. /evidence=ECO:0000250|UniProtKB:Q03519	413..432		4/31 (13%)