DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mdr49 and Tap1

DIOPT Version :10

Sequence 1:NP_523724.2 Gene:Mdr49 / 36428 FlyBaseID:FBgn0004512 Length:1302 Species:Drosophila melanogaster
Sequence 2:NP_038711.2 Gene:Tap1 / 21354 MGIID:98483 Length:724 Species:Mus musculus


Alignment Length:621 Identity:186/621 - (29%)
Similarity:309/621 - (49%) Gaps:96/621 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 FLLVVSLLVATAASAFIPYFMIIYGEFTS-LLVDRTVGVGTSSPAFALPMFGGGQQLTNASKEEN 107
            :|::|.|:::......||:|.   |..|. :|.|:||      |:|...::              
Mouse   164 YLVLVLLILSCLGEMAIPFFT---GRITDWILQDKTV------PSFTRNIW-------------- 205

  Fly   108 NQAIIDDATAFGIGSLVGSVAMFLLITLAIDLAN----RIALNQI-DRIRKLFLEAMLRQDIAWY 167
                              .:::..:.:.|::.|:    .|.:..: .|:.:....|:|||:..::
Mouse   206 ------------------LMSILTIASTALEFASDGIYNITMGHMHGRVHREVFRAVLRQETGFF 252

  Fly   168 DTSSGSNFASKMTEDLDKLKEGIGEKIVIVVFLIMTFVIGIVSAFVYGWKLTLVVLSCVPFIIAA 232
            ..:...:..|::|||...:.|.|...:.::::.:...:..:|..|.....||||.|..:|.:...
Mouse   253 LKNPAGSITSRVTEDTANVCESISGTLSLLLWYLGRALCLLVFMFWGSPYLTLVTLINLPLLFLL 317

  Fly   233 TSVVARLQGSLAEKELKSYSDAANVVEEVFSGIRTVFAFSGQEKEKERFGKLLIPAENTGRKKGL 297
            ...:.::..|||.|..:|.:.:..|..|..|.:.||.:|:.:|.|.::|.:.|...:...:|:.|
Mouse   318 PKKLGKVHQSLAVKVQESLAKSTQVALEALSAMPTVRSFANEEGEAQKFRQKLEEMKTLNKKEAL 382

  Fly   298 ----------YSGMGNALSWLIIYLCMAL----AIWYG--VTLILDERDLPDRVYTPAVLVIVLF 346
                      .|||  .|...|:||...|    |:..|  |:.:|.:..     :|.||.|::..
Mouse   383 AYVAEVWTTSVSGM--LLKVGILYLGGQLVIRGAVSSGNLVSFVLYQLQ-----FTQAVQVLLSL 440

  Fly   347 AVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMDEKGN-RPENTAGHIRFEGIRFR 410
                           ..::..|..:.:.:|..:|| :...|:  .|: .|.|..|.:.|:.:.|.
Mouse   441 ---------------YPSMQKAVGSSEKIFEYLDR-TPCSPL--SGSLAPSNMKGLVEFQDVSFA 487

  Fly   411 YPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRFYDPEAGSVKLDGRDLRTLNVGW 475
            ||.:|.|::|:|||..:.||...|.||.:|.||||:..|:|..|.|..|.:.|||:.|...:..:
Mouse   488 YPNQPKVQVLQGLTFTLHPGTVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGQCLVQYDHHY 552

  Fly   476 LRSQIGVVGQEPVLFATTIGENIRYG-RPSATQADIEKAARAANCHDFITRLPKGYDTQVGEKGA 539
            |.:|:..|||||:||..:..|||.|| ..:.|..:|...|..:..||||:..|:||||:|||.|.
Mouse   553 LHTQVAAVGQEPLLFGRSFRENIAYGLNRTPTMEEITAVAVESGAHDFISGFPQGYDTEVGETGN 617

  Fly   540 QISGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSAL----ELASQGPTTLVVAHRLS 600
            |:||||:|.:|:||||:|:|.:|:||:||||||..::.|||..|    :.||:  |.|::..:||
Mouse   618 QLSGGQRQAVALARALIRKPLLLILDDATSALDAGNQLRVQRLLYESPKRASR--TVLLITQQLS 680

  Fly   601 TITNADKIVFLKDGVVAEQGTHEELMERRGLYCELV 636
            ....|..|:||::|.|.|||||.:||:|.|.|..:|
Mouse   681 LAEQAHHILFLREGSVGEQGTHLQLMKRGGCYRAMV 716

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mdr49NP_523724.2 MdlB 44..643 CDD:440747 186/621 (30%)
MdlB 720..1299 CDD:440747
Tap1NP_038711.2 3a01208 21..716 CDD:273363 185/619 (30%)
Part of the peptide-binding site. /evidence=ECO:0000250|UniProtKB:Q03518 351..396 10/44 (23%)
Part of the peptide-binding site. /evidence=ECO:0000250|UniProtKB:Q03518 429..463 8/54 (15%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.