Protein Alignment Mdr49 and haf-7

DIOPT Version :9

• Sequence 1: NP_523724.2
• Gene: Mdr49 / 36428
• FlyBaseID: FBgn0004512
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_506645.1
• Gene: haf-7 / 190115
• WormBaseID: WBGene00001817
• Length: 807
• Species: Caenorhabditis elegans
• Alignment Length: 621
• Identity: 206/621 - (33%)
• Similarity: 314/621 - (50%)
• Gaps: 46/621 - (7%)

  Fly   681 PELQTSGSSRDSGFRASTRRKRRSQRRKKKKDKEVVSKVSFTQLMKLNSPEWRFIVVGGIASVMH 745
            |...||.:||.|    ||..:......|::|:|.:.......|::||.|.:|::.
 Worm   183 PTAATSSTSRSS----STDEEDNDAVSKEEKEKRLPLLTHLWQIVKLCSVQWKWF---------- 233

  Fly   746 GATFPLWGLFFGDFFGILSDGDDDVVRAEVLKISMIFVGIGLMAGLGNMLQTYMFTTAGV----- 805
            .|.:.|  ||......::    :..:.::::..::......::.....:|....||.|.|
 Worm   234 SAAYVL--LFVDCILNLI----EPALYSQMMSTAIRMKSFDVLKRACIVLAAVQFTEATVNTVRY 292

  Fly   806 -------KMTTR-LRKRAFGTIIGQDIAYFDDERNSVGALCSRLASDCSNVQGATGARVGTMLQA 862
                   ::|.| :|...|..|:.|||::|||  |..|.|.||:..|..::..:....:.|.:..
 Worm   293 ICMQYAERLTARNIRVSLFRAILHQDISFFDD--NKTGQLMSRITKDSESISNSLPVYIETTVNN 355

  Fly   863 VATLVVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMKSAQKAKASIEEASQVAVEAITNI 927
            ...|.....:.|.:|||..:.|.||.|::.|:....|..:.|.::|...:...:::...|.::.|
 Worm   356 SFMLFGSAPIMFYYSWQLAISTFVTFPIILLTTKFYGLIVEKLSEKENDATAVSNETVEEVLSAI 420

  Fly   928 RTVNGLCLERQVLDQYVQQIDRVDIACRRKVRFRGLVFALGQAAPFLAYGISMY-YGGILVAEER 991
            |||.....|:....:|.:..|.......:.|.| |..|....|..:....:.:| |||.|....|
 Worm   421 RTVRSFAAEKIENMRYTRDTDAWFKISTKTVVF-GTFFNYFWATMWNIEDVIIYLYGGYLTLNGR 484

  Fly   992 MNYEDIIKVAEALIFGSWMLGQAL-AYAPNVNDAILSAGRLMDLFKRTSTQPNPPQSPYNTVEKS 1055
            |..:.::    ..||..|.|..|| |::...:|.:.:.|....:....:.||...........:.
 Worm   485 MEPDALL----TYIFYHWRLHSALNAFSSLFSDVMKTIGSSRKVIHIMNRQPELDYEFGTETPEI 545

  Fly  1056 EGDIVYENVGFEYPTRKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDPVSGSVNL 1120
            .|:|::|:|.|.|||||...:|..:||:|....|:|||||||:||||.|.|:.::|.|.||.:.:
 Worm   546 VGNIIFEDVEFAYPTRKNANVLNKINLSIDPGKTIALVGPSGNGKSTLVSLIQQFYTPQSGRILI 610

  Fly  1121 SGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNIHNFISA 1185
            .|.|..........:.:.||:|||.||..|:.|||.||.....|..|..:.|.|   |:|.|:|.
 Worm   611 DGTPIQNIDHLHYHTNIALVAQEPTLFSGTVRENILYGLENGTDEDMMRVAEMA---NVHEFVSK 672

  Fly  1186 LPQGYDTRLG-KTSQLSGGQKQRIAIARALVRNPKILILDEATSALDLESEKVVQQALDEARSGR 1249
            :.:||||:.| |..|:||||||||||||||:|:|::|||||||||||.|||.:||:||:.....|
 Worm   673 MEKGYDTKCGEKGVQMSGGQKQRIAIARALIRDPRVLILDEATSALDSESEAMVQEALNRCARER 737

  Fly  1250 TCLTIAHRLTTVRNADLICVLKRGVVVEHGTHDELM 1285
            |.|.|||||:|||:||.|.|:::|.|.|.|.|:|||
 Worm   738 TVLVIAHRLSTVRSADRIAVIEKGNVTEMGNHEELM 773

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	34..640	CDD:224055
		ABC_membrane	116..352	CDD:279056
		ABC_MTABC3_MDL1_MDL2	402..636	CDD:213216
		MdlB	735..1299	CDD:224055	190/567 (34%)
		ABC_membrane	739..998	CDD:279056	60/272 (22%)
		ABC_MTABC3_MDL1_MDL2	1059..1298	CDD:213216	118/228 (52%)
haf-7	NP_506645.1	3a01208	17..784	CDD:273363	206/621 (33%)
		ABC_membrane	238..494	CDD:279056	59/268 (22%)
		ABC_MTABC3_MDL1_MDL2	549..787	CDD:213216	118/228 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810