DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr49 and pgp-7

DIOPT Version :9

Sequence 1:	NP_523724.2	Gene:	Mdr49 / 36428	FlyBaseID:	FBgn0004512	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_001361833.1	Gene:	pgp-7 / 188697	WormBaseID:	WBGene00004001	Length:	1152	Species:	Caenorhabditis elegans

Alignment Length:	1177	Identity:	369/1177 - (31%)
Similarity:	594/1177 - (50%)	Gaps:	86/1177 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 LFRYSTRCERFLLVVSLLVATAASAFIPYFMIIYGEFTSLLVDRTVGVG--TSSPAFALPMFGGG 96
            :|:.::..|:||.::.:..:.......|:.....||...:||..|..:.  |..||
Worm    31 IFKCTSCFEKFLFLIGVFFSLVTGLCQPFVSYTLGETAQVLVTITNAINNKTIDPA--------- 86

  Fly    97 QQLTNASKEENNQAIIDDATAFGIGSLVGSVAMFLLITLAIDLANRIALNQIDRIRKLFLEAMLR 161
             .|..| .|:..:.:......|    .:...|.|...::...:...:..|...|:||.::..:||
Worm    87 -DLKKA-YEQYERGMYQVVLYF----FLCGCAYFTFASIQHAIMKYVGDNTTYRVRKQYISRLLR 145

  Fly   162 QDIAWYDTSSGSNFASKMTEDLDKLKEGIGEKIVIVVFLIMTFVIGIVSAFVYGWKLT------L 220
            :|..::|..|..:.::.:.::|::.:|...|||.::..|:..||:|...||...|:|.      .
Worm   146 KDAEYFDNVSTGHLSTVLNDNLERFREVFNEKIALIFALLTDFVVGTALAFYTDWRLASYGIFFS 210

  Fly   221 VVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEEVFSGIRTVFAFSGQEKEKERFGKLL 285
            :.::...||.:|.  |.:..|    |:...|::|.::..:.....:||.:.:||..|.||:.:.|
Worm   211 LGIAFSGFINSAG--VMKTTG----KQNTHYANAGSIAFQTLGAYKTVCSLNGQNTEIERYTEEL 269

  Fly   286 IPAENTGRKKGLYSGMGNALSWLIIYLCMALAIWYGVTLILDERDLPDRVYT----PAVLVIVLF 346
            ...|..|..:.|...:....::........:.::.|..:|          |:    |||:|.:..
Worm   270 KAGEKYGIHRALMYSISRGFTYFFCNSLNTVILYVGANMI----------YSGSLEPAVVVRIFH 324

  Fly   347 AVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMDEKGNRPE-NTAGHIRFEGIRFR 410
            .::.||..|..|.||:..:|.|.::...:..::.:...|...||.....| ...|:|.|:.::|.
Worm   325 YMMFGAFCLSEALPHISRLAGAISSTAPIAEMLIKEDNVIEKDETDYDVEVEVNGNISFKNVKFS 389

  Fly   411 YPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRFYDPEAGSVKLDGRDLRTLNVGW 475
            ||.|||.::|||::.||..|:.:|.|||||.||||::||:..:|:.::|::.:||.||..:|:..
Worm   390 YPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKR 454

  Fly   476 LRSQIGVVGQEPVLFATTIGENIRYGRPSATQADIEKAARAANCHDFITRLPKGYDTQVGEKGAQ 540
            ||..||||.||||||.|||.||||:|.|:.:..:|..|.|.||.:||:...|||..|.|||:|.|
Worm   455 LRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQ 519

  Fly   541 ISGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSALELASQGPTTLVVAHRLSTITNA 605
            :||||||||||||.|||.|::|||||||||||..||:.||.|||.||||.||:|||||||||.||
Worm   520 LSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKALENASQGRTTIVVAHRLSTIRNA 584

  Fly   606 DKIVFLKDGVVAEQGTHEELMERRGLYCELVSITQRKEATEADE-GAVAGRPLQKSQNLS----- 664
            .||:.::.|.:.|.|.|:||:.:||:|.:||.....:...:.:| ..:|.|  |.||.||
Worm   585 SKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLLESHDDHEELPPLAAR--QLSQELSPLHSY 647

  Fly   665 --DEETDDDEEDEEEDEEPELQTSGSSRDSGFRASTRRKRRSQRRKKKKDKEVVSKVSFTQLMKL 727
              ...|.:|....::|.|                         |...:..||...|.:..:::|.
Worm   648 AIQRSTSNDAGVHDDDME-------------------------RILDELSKEGAKKSNLREIVKQ 687

  Fly   728 NSPEWRFIVVGGIASVMHGATFPLWG-LFFGDFFGILSDGDDDVVRAEVLKISMIFVGIGLMAGL 791
            ..|::.|:.:....|.:.|.::|:.. |....:.|....|:|.:..:.:..:|.:|:.:  ...|
Worm   688 CRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGEDMLYYSHLWALSFMFLAV--FRPL 750

  Fly   792 GNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERNSVGALCSRLASDCSNVQGATGARV 856
            ....|.|.|.....:::||||.::|..::....|::||..:|...|.:||.:|.|||:.|...|:
Worm   751 TLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRL 815

  Fly   857 GTMLQAVATLVVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMKSAQKAKASIEEASQVAV 921
            |.::..|..:.:.:....::.|:.||..|:..||:.|:.|........|.|:...:.|.:::.|:
Worm   816 GCVIMTVVAISIAITTASLYCWKMTLEVLIFFPLLYLAEYCYDAATETSIQEDTIAFENSNRTAI 880

  Fly   922 EAITNIRTVNGLCLERQVLDQYVQQIDRVDIACRRKVRFRGLVFALGQAAPFLAYGISMYYGGIL 986
            ||:.|:|||..|.||.:::....:.:.::..:..::...:|....|..:.....|.:|..:|..|
Worm   881 EALENMRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLSCYLFVYSVSFKFGTYL 945

  Fly   987 VAEERMNYEDIIKVAEALIFGSWMLGQALAYAPNVNDAILSAGRLMDLFKRTSTQPNPPQSPYNT 1051
            ...:.:...|...:.|.|...:.|.|.|.||.|:...|:.:||.:..||...:|.|.........
Worm   946 ALRKEVAPMDTYLILETLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKN 1010

  Fly  1052 VEKSEGDIVYENVGFEYPTRKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDPVSG 1116
            :||  |:|:.|||.|.|..|....||.|:||.:....|:|||||||.||||.:.||.|:|..|.|
Worm  1011 IEK--GEIIGENVQFHYDQRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDG 1073

  Fly  1117 SVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNIHN 1181
            .|.:......:..|:.|||.|.||||||.||:.:|.||:.||  ....|...|:.:|.:.:|..|
Worm  1074 EVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENLLYG--LTRSVPQLELEKALQTANAFN 1136

  Fly  1182 FISALPQ 1188
            |:...||
Worm  1137 FVFQFPQ 1143

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	34..640	CDD:224055	214/618 (35%)
		ABC_membrane	116..352	CDD:279056	51/245 (21%)
		ABC_MTABC3_MDL1_MDL2	402..636	CDD:213216	132/233 (57%)
		MdlB	735..1299	CDD:224055	136/455 (30%)
		ABC_membrane	739..998	CDD:279056	61/259 (24%)
		ABC_MTABC3_MDL1_MDL2	1059..1298	CDD:213216	57/130 (44%)
pgp-7	NP_001361833.1	MdlB	42..621	CDD:224055	211/609 (35%)
		ABC_MTABC3_MDL1_MDL2	381..618	CDD:213216	134/236 (57%)
		ABC_6TM_Pgp_ABCB1_D2_like	686..994	CDD:350022	75/309 (24%)
		TM helix 1	695..718	CDD:350022	4/22 (18%)
		TM helix 2	733..781	CDD:350022	11/49 (22%)
		TM helix 3	790..835	CDD:350022	12/44 (27%)
		TM helix 4	836..885	CDD:350022	14/48 (29%)
		TM helix 5	897..947	CDD:350022	6/49 (12%)
		TM helix 6	956..989	CDD:350022	10/32 (31%)
		P-loop_NTPase	1019..>1143	CDD:393306	54/125 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	97	1.000	Domainoid score	I4536
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.790