DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mdr49 and Abcb4

DIOPT Version :9

Sequence 1:NP_523724.2 Gene:Mdr49 / 36428 FlyBaseID:FBgn0004512 Length:1302 Species:Drosophila melanogaster
Sequence 2:NP_032856.2 Gene:Abcb4 / 18670 MGIID:97569 Length:1276 Species:Mus musculus


Alignment Length:1309 Identity:569/1309 - (43%)
Similarity:812/1309 - (62%) Gaps:77/1309 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 GDFQLKEGSVVDATRK-------YSYFDLFRYSTRCERFLLVVSLLVATAASAFIPYFMIIYGEF 70
            |||:|  ||:.:..|:       .....|||||...::..:.:..|:|.|..:.:|..||::||.
Mouse    16 GDFEL--GSISNQGREKKKKVNLIGLLTLFRYSDWQDKLFMFLGTLMAIAHGSGLPLMMIVFGEM 78

  Fly    71 TSLLVDRTVGVGTSSPA-FALPMFGGGQQLTNASKEENNQAIIDDATAFGIGSLVGSVAMFLLIT 134
            |...||.|...  |.|. |:|.|...|:.|     ||.........:..|.|.||.:.......|
Mouse    79 TDKFVDNTGNF--SLPVNFSLSMLNPGRIL-----EEEMTRYAYYYSGLGGGVLVAAYIQVSFWT 136

  Fly   135 LAIDLANRIALNQIDRIRKLFLEAMLRQDIAWYDTSSGSNFASKMTEDLDKLKEGIGEKIVIVVF 199
            ||       |..||.:||:.|..|:|||::.|:|....:...:::|:|:.|:.||||:|:.:...
Mouse   137 LA-------AGRQIKKIRQKFFHAILRQEMGWFDIKGTTELNTRLTDDVSKISEGIGDKVGMFFQ 194

  Fly   200 LIMTFVIGIVSAFVYGWKLTLVVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEEVFSG 264
            .|.||..|.:..|:.|||||||:::..|.:..:|:|.|::..:.::|||.:|:.|..|.||....
Mouse   195 AIATFFAGFIVGFIRGWKLTLVIMAISPILGLSTAVWAKILSTFSDKELAAYAKAGAVAEEALGA 259

  Fly   265 IRTVFAFSGQEKEKERFGKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMALAIWYGVTLILDER 329
            ||||.||.||.||.||:.|.|..|:..|.||.:.:.:...:::|:||...|||.|||.||::.:.
Mouse   260 IRTVIAFGGQNKELERYQKHLENAKKIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKE 324

  Fly   330 DLPDRVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMDEKGNR 394
                  ||....:.|.|::::||.::|.|:|.::|.|.|..|...:|:|||...::|...|:|::
Mouse   325 ------YTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHK 383

  Fly   395 PENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRFYDPEAG 459
            |:|..|::.|..:.|.||:|.:::|||||.:.|..|||||.||.|||||||.:||:||.|||..|
Mouse   384 PDNIKGNLEFSDVHFSYPSRANIKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPTEG 448

  Fly   460 SVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQADIEKAARAANCHDFIT 524
            .:.:||:|:|..||..||..||||.||||||:|||.|||||||.:.|..:||||.:.||.:|||.
Mouse   449 KISIDGQDIRNFNVRCLREIIGVVSQEPVLFSTTIAENIRYGRGNVTMDEIEKAVKEANAYDFIM 513

  Fly   525 RLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSALELASQG 589
            :||:.:||.||::|||:||||||||||||||||.|::|||||||||||..||..||:||:.|.:|
Mouse   514 KLPQKFDTLVGDRGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREG 578

  Fly   590 PTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELMERRGLYCELVSITQRKEATEADEGAVAG 654
            .||:|:|||||||.|||.|...:|||:.|||:|.|||::.|:|..||::            ..||
Mouse   579 RTTIVIAHRLSTIRNADVIAGFEDGVIVEQGSHSELMKKEGIYFRLVNM------------QTAG 631

  Fly   655 RPLQKSQNLSDEETDDDEEDEEEDEEPELQTSGSSRDSG-----FRASTRRKRRS--QRRKKKKD 712
                 ||.||:|     .|.|..||    :.:|....:|     ||.||::..:|  |.|..::.
Mouse   632 -----SQILSEE-----FEVELSDE----KAAGDVAPNGWKARIFRNSTKKSLKSPHQNRLDEET 682

  Fly   713 KEV---VSKVSFTQLMKLNSPEWRFIVVGGIASVMHGATFPLWGLFFGDFFGILSDGDDDVVRAE 774
            .|:   |..|||.:::|||..||.:.|||.:.::.:||..|.:.:...:...|...|||.|.:.:
Mouse   683 NELDANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGALQPAFSIILSEMIAIFGPGDDAVKQQK 747

  Fly   775 VLKISMIFVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERNSVGALCS 839
            ....|::|:|:|:::.....||.:.|..||..:|||||..||..::.||:::|||.:||.|||.:
Mouse   748 CNMFSLVFLGLGVLSFFTFFLQGFTFGKAGEILTTRLRSMAFKAMLRQDMSWFDDHKNSTGALST 812

  Fly   840 RLASDCSNVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMK 904
            |||:|.:.||||||.|:..:.|..|.|..|:::.|::.||.|||.|..:|.:.::..:|.:.:..
Mouse   813 RLATDAAQVQGATGTRLALIAQNTANLGTGIIISFIYGWQLTLLLLSVVPFIAVAGIVEMKMLAG 877

  Fly   905 SAQKAKASIEEASQVAVEAITNIRTVNGLCLERQVLDQYVQQIDRVDIACRRKVRFRGLVFALGQ 969
            :|::.|..:|.|.::|.|||.|||||..|..||:....||:::........||....|:.|::.|
Mouse   878 NAKRDKKEMEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLHGPYRNSVRKAHIYGITFSISQ 942

  Fly   970 AAPFLAYGISMYYGGILVAEERMNYEDIIKVAEALIFGSWMLGQALAYAPNVNDAILSAGRLMDL 1034
            |..:.:|.....:|..|:....|.::|:|.|..|::.|:..||.|.::||:...|.|||..|..|
Mouse   943 AFMYFSYAGCFRFGSYLIVNGHMRFKDVILVFSAIVLGAVALGHASSFAPDYAKAKLSAAYLFSL 1007

  Fly  1035 FKRTSTQPNPPQSPYN----TVEKSEGDIVYENVGFEYPTRKGTPILQGLNLTIKKSTTVALVGP 1095
            |:|     .|....|:    ..:|.||.:.:..|.|.||||...|:||||:|.:||..|:||||.
Mouse  1008 FER-----QPLIDSYSGEGLWPDKFEGSVTFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGS 1067

  Fly  1096 SGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYGNN 1160
            ||.||||.||||.|:|||::|||.|.|..:.:..:..||::||:|||||:|||.:||||||||:|
Mouse  1068 SGCGKSTVVQLLERFYDPMAGSVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDN 1132

  Fly  1161 FRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRLG-KTSQLSGGQKQRIAIARALVRNPKILILD 1224
            .| .|...||:.|||::|||.||..|||.|:||:| |.:||||||||||||||||:|.|::|:||
Mouse  1133 SR-VVPHDEIVRAAKEANIHPFIETLPQKYNTRVGDKGTQLSGGQKQRIAIARALIRQPRVLLLD 1196

  Fly  1225 EATSALDLESEKVVQQALDEARSGRTCLTIAHRLTTVRNADLICVLKRGVVVEHGTHDELMALNK 1289
            |||||||.|||||||:|||:||.||||:.|||||:|::|||||.|::.|.|.|||||.:|:|...
Mouse  1197 EATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIENGKVKEHGTHQQLLAQKG 1261

  Fly  1290 IYANLYLMQ 1298
            ||.::..:|
Mouse  1262 IYFSMVNIQ 1270

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mdr49NP_523724.2 MdlB 34..640 CDD:224055 273/606 (45%)
ABC_membrane 116..352 CDD:279056 84/235 (36%)
ABC_MTABC3_MDL1_MDL2 402..636 CDD:213216 142/233 (61%)
MdlB 735..1299 CDD:224055 259/569 (46%)
ABC_membrane 739..998 CDD:279056 87/258 (34%)
ABC_MTABC3_MDL1_MDL2 1059..1298 CDD:213216 146/239 (61%)
Abcb4NP_032856.2 PTZ00265 30..1269 CDD:240339 561/1290 (43%)
ABC_membrane 58..342 CDD:279056 106/303 (35%)
ABC_MTABC3_MDL1_MDL2 392..628 CDD:213216 144/247 (58%)
Interaction with HAX1. /evidence=ECO:0000250 622..646 11/45 (24%)
ABC_membrane 712..982 CDD:279056 91/269 (34%)
ABC_MTABC3_MDL1_MDL2 1031..1270 CDD:213216 146/239 (61%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 207 1.000 Domainoid score I2870
eggNOG 1 0.900 - - E2759_KOG0055
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG63700
OrthoDB 1 1.010 - - D186078at2759
OrthoFinder 1 1.000 - - FOG0000106
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100059
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R932
SonicParanoid 1 1.000 - - X92
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
109.760

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