Protein Alignment Mdr49 and Abcb1b

DIOPT Version :10

• Sequence 1: NP_523724.2
• Gene: Mdr49 / 36428
• FlyBaseID: FBgn0004512
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_035205.1
• Gene: Abcb1b / 18669
• MGIID: 97568
• Length: 1276
• Species: Mus musculus
• Alignment Length: 1308
• Identity: 553/1308 - (42%)
• Similarity: 795/1308 - (60%)
• Gaps: 79/1308 - (6%)

  Fly     3 KKEESRLPQAGDFQLKEGSVVDATRKYSYFDLFRYSTRCERFLLVVSLLVATAASAFIPYFMIIY 67
            |:::.:.|..|                 .|.:|||:...::..:::..|.|......:|..|:::
Mouse    24 KEKKEKKPAVG-----------------VFGMFRYADWLDKLCMILGTLAAIIHGTLLPLLMLVF 71

  Fly    68 GEFTSLLVDRTVGVGTSSPAFALPMF----GGGQQL--TNASKEENNQAIIDDATAFGIGSLVGS 126
            |..|...        |.:.|..||..    |....|  :|:|.||.........|..|.|.|:.:
Mouse    72 GNMTDSF--------TKAEASILPSITNQSGPNSTLIISNSSLEEEMAIYAYYYTGIGAGVLIVA 128

  Fly   127 VAMFLLITLAIDLANRIALNQIDRIRKLFLEAMLRQDIAWYDTSSGSNFASKMTEDLDKLKEGIG 191
            .....|..||       |..||.:||:.|..|::.|:|.|:|........:::|:|:.|:.:|||
Mouse   129 YIQVSLWCLA-------AGRQIHKIRQKFFHAIMNQEIGWFDVHDVGELNTRLTDDVSKINDGIG 186

  Fly   192 EKIVIVVFLIMTFVIGIVSAFVYGWKLTLVVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAAN 256
            :||.:....|.||:.|.:..|:.|||||||:|:..|.|..::::.|::..|...|||::|:.|..
Mouse   187 DKIGMFFQSITTFLAGFIIGFISGWKLTLVILAVSPLIGLSSALWAKVLTSFTNKELQAYAKAGA 251

  Fly   257 VVEEVFSGIRTVFAFSGQEKEKERFGKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMALAIWYG 321
            |.|||.:.||||.||.||:||.||:.|.|..|:|.|.||.:.:.:...:::|::|...|||.|||
Mouse   252 VAEEVLAAIRTVIAFGGQQKELERYNKNLEEAKNVGIKKAITASISIGIAYLLVYASYALAFWYG 316

  Fly   322 VTLILDERDLPDRVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVD 386
            .:|:|...      |:...::.|.|::::|..::|..:|::||.|.|..|...:|.|||....:|
Mouse   317 TSLVLSNE------YSIGEVLTVFFSILLGTFSIGHLAPNIEAFANARGAAFEIFKIIDNEPSID 375

  Fly   387 PMDEKGNRPENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQ 451
            ....||.:|::..|::.|:.:.|.||:|.:|:|||||.:.|..|||||.||.|||||||.:||||
Mouse   376 SFSTKGYKPDSIMGNLEFKNVHFNYPSRSEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQ 440

  Fly   452 RFYDPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQADIEKAARA 516
            |.|||..|.|.:||:|:||:||.:||..||||.||||||||||.|||||||...|..:||||.:.
Mouse   441 RLYDPLEGVVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKE 505

  Fly   517 ANCHDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQS 581
            ||.:|||.:||..:||.|||:|||:||||||||||||||||.|::|||||||||||..||..||:
Mouse   506 ANAYDFIMKLPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQA 570

  Fly   582 ALELASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELMERRGLYCELVSITQRKEATE 646
            ||:.|.:|.||:|:||||||:.|||.|.....||:.|||.|:|||..:|:|.:|| :||.:
Mouse   571 ALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLV-MTQTR---- 630

  Fly   647 ADEGAVAGRPLQKSQNL--SDEETDDDEEDEEEDEEPELQTSGSSRDSGFRASTRRKRRSQRRKK 709
                   |..::...|.  |..:||..|...||.:.|.:      |.|.:| |..||:..:||..
Mouse   631 -------GNEIEPGNNAYGSQSDTDASELTSEESKSPLI------RRSIYR-SVHRKQDQERRLS 681

  Fly   710 KKD--KEVVSKVSFTQLMKLNSPEWRFIVVGGIASVMHGATFPLWGLFFGDFFGILS-DGDDDVV 771
            .|:  .|.|..|||.:::.||..||.:::||.:.:|::|...|::.:.|....|:.| |.|.:..
Mouse   682 MKEAVDEDVPLVSFWRILNLNLSEWPYLLVGVLCAVINGCIQPVFAIVFSRIVGVFSRDDDHETK 746

  Fly   772 RAEVLKISMIFVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERNSVGA 836
            |......|:.|:.:||::.:....|.:.|..||..:|.|:|...|.:::.|||::|||.:||.|:
Mouse   747 RQNCNLFSLFFLVMGLISFVTYFFQGFTFGKAGEILTKRVRYMVFKSMLRQDISWFDDHKNSTGS 811

  Fly   837 LCSRLASDCSNVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRF 901
            |.:|||||.|:|:||.|||:..:.|.||.|..|:::..|:.||.|||.:|.:||:.|...:|.:.
Mouse   812 LTTRLASDASSVKGAMGARLAVVTQNVANLGTGVILSLVYGWQLTLLLVVIIPLIVLGGIIEMKL 876

  Fly   902 IMKSAQKAKASIEEASQVAVEAITNIRTVNGLCLERQVLDQYVQQIDRVDIACRRKVRFRGLVFA 966
            :...|.|.|..:|.:.::|.|||.|.||:..|..|::....|.|.:........:|....|:.|:
Mouse   877 LSGQALKDKKQLEISGKIATEAIENFRTIVSLTREQKFETMYAQSLQVPYRNAMKKAHVFGITFS 941

  Fly   967 LGQAAPFLAYGISMYYGGILVAEERMNYEDIIKVAEALIFGSWMLGQALAYAPNVNDAILSAGRL 1031
            ..||..:.:|.....:|..|||::.|.:|:::.|..|::||:...|...::||:...|.:||..:
Mouse   942 FTQAMMYFSYAACFRFGAYLVAQQLMTFENVMLVFSAVVFGAMAAGNTSSFAPDYAKAKVSASHI 1006

  Fly  1032 MDLFKRTSTQPNPPQSPYNTVEKS----EGDIVYENVGFEYPTRKGTPILQGLNLTIKKSTTVAL 1092
            :.:.::|     |....|:|....    ||::.:..|.|.||||...|:||||:|.:||..|:||
Mouse  1007 IRIIEKT-----PEIDSYSTEGLKPTLLEGNVKFNGVQFNYPTRPNIPVLQGLSLEVKKGQTLAL 1066

  Fly  1093 VGPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAY 1157
            ||.||.||||.||||.|:|||::|||.|.|....:..:..||:.||:|||||:|||.:|||||||
Mouse  1067 VGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLNVQWLRAHLGIVSQEPILFDCSIAENIAY 1131

  Fly  1158 GNNFRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRLG-KTSQLSGGQKQRIAIARALVRNPKIL 1221
            |:|.| .||.:||:.|||::|||.||.:||..|:||:| |.:||||||||||||||||||.|.||
Mouse  1132 GDNSR-AVSHEEIVRAAKEANIHQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHIL 1195

  Fly  1222 ILDEATSALDLESEKVVQQALDEARSGRTCLTIAHRLTTVRNADLICVLKRGVVVEHGTHDELMA 1286
            :|||||||||.|||||||:|||:||.||||:.|||||:|::|||||.|::.|.|.|||||.:|:|
Mouse  1196 LLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIENGKVKEHGTHQQLLA 1260

  Fly  1287 LNKIYANL 1294
            ...||.::
Mouse  1261 QKGIYFSM 1268

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	44..643	CDD:440747	267/604 (44%)
		MdlB	720..1299	CDD:440747	258/581 (44%)
Abcb1b	NP_035205.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26		1/1 (100%)
		PTZ00265	55..1270	CDD:240339	546/1260 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	633..659		7/25 (28%)