DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mdr49 and pgp-13

DIOPT Version :9

Sequence 1:NP_523724.2 Gene:Mdr49 / 36428 FlyBaseID:FBgn0004512 Length:1302 Species:Drosophila melanogaster
Sequence 2:NP_001359545.1 Gene:pgp-13 / 184845 WormBaseID:WBGene00004007 Length:1323 Species:Caenorhabditis elegans


Alignment Length:1341 Identity:452/1341 - (33%)
Similarity:707/1341 - (52%) Gaps:164/1341 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 SYFDLFRYSTRCERFLLVVSLLVATAASAFIPYFMIIYGEFTSLLVDRTVGVGTSSPAFALPMFG 94
            |...|||::|..:..||::.|:.:..:....|...||.|..|::|:                   
 Worm    77 SLLQLFRFATTFDYILLLIGLITSVISGVSQPVLAIISGRMTNVLL------------------- 122

  Fly    95 GGQQLTNASKEENNQAIIDDATAFGIGSLV--GSVAMFLLITLAIDLANRIALNQIDRIRKLFLE 157
               .:...|||...:.:.:.....|:|..|  .....::..       .|:....:..:|..::.
 Worm   123 ---VIDPLSKEFKTKTMENVYIFLGLGIFVSINDFCQYMCF-------QRVCSRMMTVMRNRYIS 177

  Fly   158 AMLRQDIAWYDTSSGSNFASKMTEDLDKLKEGIGEKIVIVVFLIMTFVIGIVSAFVYGWKLTLVV 222
            ::|||:..|:|.:......:::.::::::::|:|:|:.:::..|...:..:|.:.:|.|:|.|::
 Worm   178 SILRQNAGWFDKNLSGTITTRLNDNMERIQDGVGDKLGVLIRGISMVIASVVISLIYEWRLALMM 242

  Fly   223 LSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEEVFSGIRTVFAFSGQEKEKERFGKLLIP 287
            |..:|......::::|.......:||:...:|..:.||...|:||:.||:|||:...::.|.|  
 Worm   243 LGLIPVSTICMTLLSRFLEKSTGEELEKVGEAGAIAEECLMGVRTIQAFNGQEEMVAKYEKQL-- 305

  Fly   288 AENTGRKKGLYSGM------GNALSWLIIYLCMALAIWYGVTLILDERDLPDRVYTPAVLVIVLF 346
              |:|:|..::.|.      |....||:.:  |...|.||..|:     ....:.:|..:.|::.
 Worm   306 --NSGKKHAIWGGFWSGFFGGIFFFWLMAF--MGCGILYGGYLL-----KVGIIKSPGDVFIIVV 361

  Fly   347 AVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMDEKGNRPENTAGHIRFEGIRFRY 411
            |:::||..||..|||:..:..|..|..:::..|||..::||....|.:.|...|.:.||.:.|||
 Worm   362 AMLLGAYFLGLISPHLMVLLNARVAAASIYKTIDRVPKIDPYSRHGKKIEKVVGKVTFENVHFRY 426

  Fly   412 PARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRFYDPEAGSVKLDGRDLRTLNVGWL 476
            |.|.:.::|.||.:.|.||.:||.||.|||||||.:.|:.|.|:||.|||::||.|:|.||:.||
 Worm   427 PTRKEAKVLNGLNLTVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEQGSVQIDGVDVRDLNLEWL 491

  Fly   477 RSQIGVVGQEPVLFATTIGENIRYGRPSATQADIEKAARAANCHDFITRLPKGYDTQVGEKGAQI 541
            |:.:|:|.|||:||..||..|:.:|.|.||:..:.:..:.||.||||.::|||||||:|:.|.|:
 Worm   492 RNVVGIVQQEPILFNDTIHNNLLFGNPDATRETMIRVCKMANAHDFIKKMPKGYDTQIGDGGVQL 556

  Fly   542 SGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSALELASQGPTTLVVAHRLSTITNAD 606
            |||||||:||||.|:|.|:||||||||||||..||..|||||..||:|.||:::|||||||..||
 Worm   557 SGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESVVQSALNNASKGRTTIMIAHRLSTIREAD 621

  Fly   607 KIVFLKDGVVAEQGTHEELMERRGLYCELVSITQRKEATEADEGAVAGRPLQKSQNLSDEETDDD 671
            ||||.:.||:.|.|.||||:...|.|.:||    :.:|.:.|...:|   |:|           :
 Worm   622 KIVFFEKGVIVEAGNHEELVNLGGRYFDLV----KAQAFKQDPDEIA---LEK-----------E 668

  Fly   672 EEDE-EEDEEPEL----------QTSGSSRDSGFRASTRRKRRSQRRKK---------------- 709
            |||: :|.::|.:          ::||.|....||..:.......|.:|                
 Worm   669 EEDQFDEFDKPTVFNRKVSVRNSRSSGRSGSEEFRRGSLANHSFDRFRKASHIPSAEDEAFALRV 733

  Fly   710 ----KKDKEVVSKVSFTQLMKLNSPEWRFIVVGGIASVMHGATFPLWGLFFG---DFFGILSDGD 767
                :||.|:.:  .|..:.|.....:.::::|..|:::.|...|.:.|.|.   :.|..:..|.
 Worm   734 KETMEKDGEITA--GFLDIFKNAQGNYTYMLIGLSAALIRGLDLPTFALLFAWVFEGFEFVPYGG 796

  Fly   768 DDVVRAEVLKISMIFVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERN 832
            ..:.|..:..|:....|:|:.  ....|.|.||......:..|.|..||..::.||.||||:..:
 Worm   797 KMMHRLAMSVIAHCAAGLGIW--FFQTLSTVMFAIVSENLGVRFRVAAFRNLLYQDAAYFDNPAH 859

  Fly   833 SVGALCSRLASDCSNVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTLVTLPLVCLSVYL 897
            :.|:|.:|||:|...|:.....|:..::.|.|.::..:.:||:..||..:|....       ::|
 Worm   860 APGSLITRLAADPPCVKAVVDGRMMQVVYATAAVIACVTIGFINCWQVAILGTAL-------IFL 917

  Fly   898 EGRFIMKSAQKAKASI--------EEASQVAVEAITNIRTVNGLCLERQVLDQYVQQIDRVDIAC 954
            .| ||| :....|.||        ::|.::|:|.|.|::|:..|...|:.|:.|..:..:     
 Worm   918 LG-FIM-AGLAFKISIVAAEHMENDDAGKIAIEIIENVKTIQLLTRTRRFLNSYENESKK----- 975

  Fly   955 RRKVRFRGLVFALGQAAPFLAYGIS---MYYGG---ILVAEERMNYED------------IIKVA 1001
            |::...|..|:..      :.|.||   |||..   ..:|...:|..|            ::...
 Worm   976 RKRTELRKSVYEA------VNYCISQNFMYYMSCFCFALAIRIINQGDQTVDKTFRCLMAMMLCC 1034

  Fly  1002 EALIFGSWMLGQALAYAPNVNDAILSAGRLMDLFKRTSTQPNPPQSPYNTVEKSEGDIVYENVGF 1066
            |.:|..:       .:.|....|..:||::.:|..|   ||........|..:..|:|::|||.|
 Worm  1035 EGIIMSA-------QFFPQFVGAKSAAGQMFNLINR---QPQTGDLKSGTKPEIRGNILFENVKF 1089

  Fly  1067 EYPTRKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFPLD 1131
            .||.|...|:::.|..|..:..|||||||||||||||:.:|.|:||...|::.:.|.......|.
 Worm  1090 SYPQRPHQPVMKQLQWTALRGQTVALVGPSGSGKSTCIGMLERFYDVTGGALRMDGQDIKNISLY 1154

  Fly  1132 TLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRLG- 1195
            .||:::.||.|||.||..||.||:..|   ..||.:::|.:|.:.:|.:.|:..||.|.||.:| 
 Worm  1155 HLRTQMALVGQEPRLFVGTIRENVCLG---LKDVPLEKINQALELANANRFLGNLPDGIDTEVGE 1216

  Fly  1196 KTSQLSGGQKQRIAIARALVRNPKILILDEATSALDLESEKVVQQALDEARSGRTCLTIAHRLTT 1260
            :..||||||||||||||||||:||||:|||||||||.|||:.||:|||.||.||||:||||||::
 Worm  1217 RGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRLSS 1281

  Fly  1261 VRNADLICVLKRGVVVEHGTHDELMALNKIYANLYLMQQVS 1301
            ::|:|||..:..|.|.|.|||.|||.|...|..|...|.::
 Worm  1282 IQNSDLIVYIDDGRVQESGTHKELMQLKGKYFELIKKQDLA 1322

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mdr49NP_523724.2 MdlB 34..640 CDD:224055 219/613 (36%)
ABC_membrane 116..352 CDD:279056 52/243 (21%)
ABC_MTABC3_MDL1_MDL2 402..636 CDD:213216 132/233 (57%)
MdlB 735..1299 CDD:224055 209/593 (35%)
ABC_membrane 739..998 CDD:279056 70/287 (24%)
ABC_MTABC3_MDL1_MDL2 1059..1298 CDD:213216 126/239 (53%)
pgp-13NP_001359545.1 PTZ00265 92..1317 CDD:240339 446/1319 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 60 1.000 Domainoid score I7003
eggNOG 1 0.900 - - E2759_KOG0055
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG63700
OrthoDB 1 1.010 - - D186078at2759
OrthoFinder 1 1.000 - - FOG0000106
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100059
Panther 1 1.100 - - O PTHR24221
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X92
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
109.790

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