Protein Alignment Mdr49 and pgp-11

DIOPT Version :10

• Sequence 1: NP_523724.2
• Gene: Mdr49 / 36428
• FlyBaseID: FBgn0004512
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_001364583.1
• Gene: pgp-11 / 183971
• WormBaseID: WBGene00004005
• Length: 1241
• Species: Caenorhabditis elegans
• Alignment Length: 1343
• Identity: 397/1343 - (29%)
• Similarity: 654/1343 - (48%)
• Gaps: 170/1343 - (12%)

  Fly    13 GDFQLKEGSVVDATR--KYSYFDLFRYSTRCERFLLVVSLLVATAASAFIPYFMIIYGEFTSLLV 75
            ||    |..|.|.|.  :.|...:..::.:.:...::.:|:.|.......|..::|.|..|.|
 Worm    15 GD----ESKVSDVTPSIRQSLNLMINFAKKSDLIFIITALICALLGGTIQPVVLLIGGWITDL-- 73

  Fly    76 DRTVGVGTSSPAFALPMFGGGQQLTNASKEENNQAIIDDATAF--GIGSLVGSVAMFLLITLAID 138
                                  .|||.:...|::.:....|..  |:|        |.:|.|.:.
 Worm    74 ----------------------YLTNGNTAGNDEFLYSVLTLIYAGLG--------FGVIILVLA 108

  Fly   139 LANRIALNQ-----IDRIRKLFLEAMLRQDIAWYDTSSGSNFASKMTEDLDKLKEGIGEKIVIVV 198
            |...:.:.:     :|.|||.||.|:||||..|.|..|..:...::.|:::.:.:|:|.|..::|
 Worm   109 LIQGVCIQRGTSRILDSIRKEFLGAVLRQDANWLDKHSSGSITCQLNENIEVISDGLGNKCCMLV 173

  Fly   199 FLIMTFVIGIVSAFVYGWKLTLVVLSCVP---FIIAATSVVARLQGSLAEKELKSYSDAAN-VVE 259
            .....|...|::.....|:||.:..:..|   |::...:.|    ..::.:||.|.|..:: ::|
 Worm   174 RGFAMFTSSIIACAFINWQLTFITFTMGPVSAFVLHLLTKV----NEVSNEELMSLSAQSHAIIE 234

  Fly   260 EVFSGIRTVFAFSGQEKEKERFGKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMALAIWYGVTL 324
            |....:|||.:.:||.....:..::....:....|...::|..:.|:..:||....:::::|..|
 Worm   235 ESILNVRTVQSCNGQNFMITKLNQVNEKIKKFYNKSTFWAGFFDGLALFVIYFITGISLFFGCRL 299

  Fly   325 ILDERDLPDRVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMD 389
            ..::     .:.....:::::..:.:....||...||:.::..|..:...|:..|:..    |..
 Worm   300 YFNQ-----EIGKAGDVILIVNTICVTGYFLGLLGPHMSSLQQAATSFLLLYKTIESA----PKS 355

  Fly   390 EKGNRPE----NTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLM 450
            | |...|    :|.|:|.|..:||:|..| |.|:|:||::.||||||||.||.|||||||.|.|:
 Worm   356 E-GKEGEIKISSTRGNIEFRDVRFKYFTR-DNEVLQGLSLQVLPGQTVALVGTSGCGKSTSIGLL 418

  Fly   451 QRFYDPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQADIEKAAR 515
            .:.|....|.:.:||:::..|:...||.|||:|.|||.||..||.|||:.|| :..:..|:.||.
 Worm   419 TKLYRASEGEILIDGKNIDMLDAKSLRQQIGIVQQEPKLFDGTIMENIKLGR-NVDEETIKTAAD 482

  Fly   516 AANCHDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQ 580
            .||...||.:|..||:|::|..|.|:||||||||.||||||..|.:|||||||||||..:|..|.
 Worm   483 IANASSFIEKLENGYETRLGPGGVQLSGGQKQRICIARALVTSPSILLLDEATSALDSHNEHIVN 547

  Fly   581 SALELASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELMERRGLYCELVSITQRKEAT 645
            .||..||:|.||:::|||||::.:.|:|..|..|...|.|||:||:...|:|..|.
 Worm   548 KALTKASEGRTTIIIAHRLSSLKSVDRIYVLDQGKTKEIGTHDELILLGGIYARLA--------- 603

  Fly   646 EADEGAVAGRPLQKSQNLSDEETDDDEEDEEEDEEPELQTSGSSRDSGFRASTRRKRRSQRRKKK 710
                         |||.:......|.|.:|                         .||:::.|||
 Worm   604 -------------KSQEVEQSSKKDWEREE-------------------------LRRAEKMKKK 630

  Fly   711 -KDKEVV------------------------SKVSFTQLMKLNS--PEWRFIVVGGIASVMHGA- 747
             :..|::                        .|:||:.:.||.:  |:.|..::..||.::..|
 Worm   631 GRTVEIIEPNSTILQEHEHNFVGSVITENEEQKISFSGISKLFNYLPKHRKTLILIIALLIPRAI 695

  Fly   748 TFPLWGLFFGDFFGILSDGDDDVVRAEVLKISMIFVGIGLMAGLGN-MLQTYMFTTAG---VKMT 808
            ....:|:.....|..|....||.:....:.::.     ..:||:.. :|.|.:....|   .::.
 Worm   696 ELCSYGIGMSFAFKTLQRSKDDYMTWNYITLAQ-----QTLAGITFWILHTSLMYLCGWLANEVM 755

  Fly   809 TRLRKRAFGTIIGQDIAYFDDERNSVGALCSRLASDCSNVQGATGARVGTMLQAVATLVVGMVVG 873
            ..:::.....::.:.|.|||:...|..|..||:.|...|.......|....:..:|..:..:::.
 Worm   756 NEVKQEMLSEVLNKPIPYFDNPETSPSACVSRIISHAHNCYACLDHRAIRFVWFIAGTIFSLLLA 820

  Fly   874 FVFSWQQTLLTL-VTLPLVCLSVYLEGRFIMKSAQKAKASIEEASQVAVEAITNIRTVNGLCLER 937
            |.|.|:..:|.| :|:.|...|::...  :...|...|:.::::.:.|||.:.:||.:..|.:|.
 Worm   821 FPFVWELGVLGLGITILLTIFSLHFVS--VAHRAHSEKSVMDKSGEFAVEIVEHIRAIKLLAVEG 883

  Fly   938 QVLDQYVQQIDRVDIACRRKVRF-RGLVFALGQAAPFLAYGISMYYGGILVAEERMNYEDIIKVA 1001
            ...:::.:.:...:| ...|:.| ..|.||:.|:..|....:..:.|.:|:...|.:.:.:....
 Worm   884 YFENKFSEYLKTSEI-YENKIGFVSSLNFAITQSYVFACDMLLFFVGTLLIYHGRYSPDKVFLAF 947

  Fly  1002 EALIFGSWMLGQALAYAPNVNDAILSAGRLMDLFKRTSTQPNPPQSPYNTVEKSE--GDIVYENV 1064
            ......:|.:.....:.|.:.....||.::...|.:..|...      :.:.|.|  |.:...:|
 Worm   948 NGAQMSAWGVMYFSPWFPEIVRGSASANQIFSFFDKNRTNST------SGLSKPEINGKVEVSDV 1006

  Fly  1065 GFEYPTRKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFP 1129
            .|.||:.....:.:|.:|.|.|..::||||.||.||||.:.:|.|:|...:|.:::.........
 Worm  1007 TFAYPSTPHRNVCEGFSLNIPKGHSIALVGASGCGKSTIISMLERFYSAKAGRISVDDNDIDGID 1071

  Fly  1130 LDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRL 1194
            ::.||:.:.:|.||||||:.||.|||..|   .|:||::|:.:|.|.:|...||.:.|.||||.:
 Worm  1072 VNHLRNNISVVGQEPVLFNATIRENITIG---IDEVSVEEVQKACKAANAAGFIESFPLGYDTIV 1133

  Fly  1195 GK-TSQLSGGQKQRIAIARALVRNPKILILDEATSALDLESEKVVQQALDEARSGRTCLTIAHRL 1258
            |: .:.||||||||||||||::|.||||:|||||||||.:||::||:||..|.:|||.:.:||||
 Worm  1134 GEGGASLSGGQKQRIAIARAIIRKPKILLLDEATSALDTQSEEIVQKALRSATTGRTSIIVAHRL 1198

  Fly  1259 TTVRNADLICVLKRGVVVEHGTHDELMALNKIYANLYLMQQVS 1301
            :||::.|.|..:.||.|.|:|||.||:|::..||.|...|.:|
 Worm  1199 STVQHCDTIYYISRGAVAEYGTHAELVAMDSKYARLVAAQSLS 1241

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	44..643	CDD:440747	196/613 (32%)
		MdlB	720..1299	CDD:440747	179/590 (30%)
pgp-11	NP_001364583.1	PTZ00265	38..1235	CDD:240339	387/1308 (30%)
		MdlB	46..610	CDD:440747	199/633 (31%)