Protein Alignment Mdr49 and mrp-3

DIOPT Version :9

• Sequence 1: NP_523724.2
• Gene: Mdr49 / 36428
• FlyBaseID: FBgn0004512
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_001359552.1
• Gene: mrp-3 / 181677
• WormBaseID: WBGene00003409
• Length: 1505
• Species: Caenorhabditis elegans
• Alignment Length: 1427
• Identity: 310/1427 - (21%)
• Similarity: 566/1427 - (39%)
• Gaps: 346/1427 - (24%)

  Fly     3 KKEESR-----LPQAGDFQL--------KEGSVVDATRKYSYFDLFRYSTRCERFLLVVSLLVAT 54
            |:|.:|     .|..|.|..        |:..:|..:...:.:.:.::......|:..:|.|:..
 Worm   263 KRERARTGSEKAPLLGTFNNYGAVNLDDKDRVIVQPSVIVTLWQIMKWEILGGSFIKFLSDLLQF 327

  Fly    55 AASAFIPYFMIIYGEFTSLLVDRTVGVGTSSPAFALPMFGGGQ---------------------- 97
            |...|:.|.::......:.|::   |:|     .|:.:|..||
 Worm   328 ANPTFLNYLILFIETPNAPLIN---GIG-----LAVGLFLAGQIKSLFMNTYFIAMTRVGAKIQT 384

  Fly    98 -----------QLTNASKEENNQAIIDDATAFGIGSLVGSVAMFLLITLAIDLANRIALNQIDRI 151
                       .|:|.::.|..           :|.:|.        .|:||         :||.
 Worm   385 MLSCAVYEKSLLLSNTARRERT-----------VGEMVN--------ILSID---------VDRF 421

  Fly   152 RKLFLEAMLRQDIAWYDTSSGSNFASKMTEDLDKLKEGIGEKIVIVVFLIMTFVIGIVSAFVYGW 216
            |      |:...|..|.:|...                     :|:..::::..||:..     |
 Worm   422 R------MITPQIQQYWSSPFQ---------------------IIICMVLLSQTIGVAV-----W 454

  Fly   217 KLTLVVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEEVFSGIRTVFAFSGQEKEKERF 281
            ...:|::|.||..|..:.:..|.|..|    :|...:...::.||.:||:.|...:.:...:|..
 Worm   455 AGIVVMISIVPINICVSMITKRWQLRL----MKYKDERIRLINEVLNGIKVVKLSAWETAMEETI 515

  Fly   282 GKLLIPAENTGRKKGLYSGMGNALS-WLIIYLCMALAIWYGVTLILDERDLPDRVYTP--AVLVI 343
            .::........::..|.....:.|: ...:::.::.   :.|.:::|    |..|.||  |.:.:
 Worm   516 ERVRDKELKMIKQSALLKTFADCLNVGAPVFVALSS---FTVFVLID----PKNVLTPNIAFVSL 573

  Fly   344 VLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDR--------PSQVD--PMDE--KGNRPE 396
            .||.::.|           ..:..|....||:..::..        ..:||  .:|:  :|....
 Worm   574 SLFNLLRG-----------PLMMAAELVAQTVQLVVSNKRVRTFLCEKEVDTAAIDKEIRGELYT 627

  Fly   397 NT----AGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRFYDPE 457
            ||    :|...::....|..:  |:|.|.|      ..:.|..||:.|.|||:|:.......:..
 Worm   628 NTVEIHSGSFAWDSAEARILS--DIEFLAG------SKELVTVVGSVGSGKSSLLLAALGEMEKV 684

  Fly   458 AGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQADI-----EKAARAA 517
            .|.|             .:|..:..:.|:|.:...::.:|:      ..|||:     :|...:.
 Worm   685 CGYV-------------GVRGSVAYLSQQPWILNQSLKKNV------LMQADLNDVLYKKVIESC 730

  Fly   518 NCHDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSA 582
            ...:.:.:||.|.||::||||..:|||||.|||:|||:.:...|..||:..||:|....|.:...
 Worm   731 ALKEDLKQLPDGDDTEIGEKGINLSGGQKARIALARAVYQSKDVYFLDDPLSAVDAHVGKHIFDN 795

  Fly   583 LELASQGP-------TTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELMERRGLYCELVSITQ 640
            :    .||       |.::|.:..|.:..:.||:.:|||.:...||:.||         |..:..
 Worm   796 V----IGPNGMLSHTTRILVTNCTSFLQESGKIIVMKDGRIKHCGTYNEL---------LTDVEA 847

  Fly   641 RKEATEADEGAVAGRPLQKSQNLSDEETDDDEEDEEEDEEPELQTSGS--SRDSGFRASTRRKRR 703
            |:...|.|      ....::|..|.||:..   :|..|..|....|||  ||.|.....:|:|.:
 Worm   848 REYLQEVD------NEYAQAQESSGEESGG---EENSDILPGSIASGSRMSRLSRLSKISRKKSK 903

  Fly   704 SQRRKKKKDKEVVSKVSFTQLMKLNSPEW----------RFIVVGGIASVMHGATFPL------- 751
            |...:|||...:::|.. ..:.::|...:          .:::...||.|:: .:|.|
 Worm   904 SSIVEKKKPDALITKEE-AAIGRVNPGVYLLYFKAMGIVTYVLPYAIAVVLN-VSFALGRSLWLT 966

  Fly   752 -WGLFFGDFFGILSDGDDDVVRAEVLKISMIFVGIGLMAGLGNMLQTYMFTT------AGVKMTT 809
             |           ||.:.|:...:.:.:.   ..:|:.||.|.....::|.:      .||..:.
 Worm   967 AW-----------SDANIDINHPDTMSVG---ARLGVYAGFGITEVIFLFFSLVLLLIGGVAASK 1017

  Fly   810 RLRKRAFGTIIGQDIAYFDDERNSVGALCSRLASDCSNVQGATGARVGTMLQAVATLVVGMVVGF 874
            .|.|.....::...::|||  ...:|.:.:|||.|...|.    .|:.:..:.:...::.||
 Worm  1018 NLHKPLLHNVLRNPLSYFD--ITPIGRIINRLAKDMEVVD----LRLSSSFRFLVMALINMV--- 1073

  Fly   875 VFSWQQTLLTLVTLPL---VCLSVYLEGRFIMKSAQKAKASIEE-ASQVAVEAITNI-RTVNGLC 934
                |..|:...|.||   :.:.|::...|::|.:.|:...::. ||.......:|. .|:.|:.
 Worm  1074 ----QTVLIVSYTTPLFIAIIIPVFIIYFFVLKYSIKSTRQLQRIASLTRSPIFSNFSETLQGIS 1134

  Fly   935 LER--QVLDQYVQQID---RVDIACRRKVRFRGLVFALGQAAPFLAYGISMYYGGILVAEERMNY 994
            ..|  |..|::|::.|   ...:.|                    :|...|....:.:..|.:..
 Worm  1135 TVRAFQWSDEFVRRNDEHLNTHVKC--------------------SYYSQMANRWLSIRLELLGN 1179

  Fly   995 EDIIKVAEALIFG------SWMLGQALAYAPNVNDAILSAGRLMDLFKRTSTQPNPPQSPYNTVE 1053
            ..|...|...|.|      :.|||.:::|:.|:.       .::::|.|   |.|..::...:||
 Worm  1180 IVIFSAAILAIIGKESGITAGMLGLSVSYSLNIT-------FMLNMFVR---QINEVETNVVSVE 1234

  Fly  1054 --------KSEGD--IVYENVGFEYPTRKGTPI--------------LQGLNLTIKKSTTVALVG 1094
                    |||.:  :...|:...:||.....|              |:.::|.|.....|.:.|
 Worm  1235 RIDEYSKTKSEAEWRLDNNNLPSNWPTGGAVNIEDYSCRYRDELDLVLKQISLNILPGQKVGVCG 1299

  Fly  1095 PSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYGN 1159
            .:|:|||:....|.|..:...|::::....::...|..||.||.::.||.|||..|:..||....
 Worm  1300 RTGAGKSSLALALFRIVEAADGNISIDQTITSHIGLHDLREKLTIIPQENVLFANTLRFNIDPKG 1364

  Fly  1160 NFRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRLGKTSQ-LSGGQKQRIAIARALVRNPKILIL 1223
            .|.|    |::..|.:.||:...:..||...::.:.:..: .|.||:|.:.:.|||:|..|:|:|
 Worm  1365 QFTD----QQLWLALENSNLKAHVELLPHKLESPVAEGGENFSVGQRQLLCLTRALLRKSKVLVL 1425

  Fly  1224 DEATSALDLESEKVVQQALDEARSGRTCLTIAHRLTTVRNADLICVLKRGVVVEHGTHDELM 1285
            ||||:.:|..::.:||..:.|..:..|.:||||||.|:.:.|.|.|:..|.:||.|...||:
 Worm  1426 DEATAGIDNRTDTMVQATIREKFADSTIITIAHRLHTIIDYDRIIVMDAGRIVEDGIPGELL 1487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	34..640	CDD:224055	134/669 (20%)
		ABC_membrane	116..352	CDD:279056	42/238 (18%)
		ABC_MTABC3_MDL1_MDL2	402..636	CDD:213216	64/245 (26%)
		MdlB	735..1299	CDD:224055	144/606 (24%)
		ABC_membrane	739..998	CDD:279056	53/282 (19%)
		ABC_MTABC3_MDL1_MDL2	1059..1298	CDD:213216	73/242 (30%)
mrp-3	NP_001359552.1	MRP_assoc_pro	25..1501	CDD:188098	310/1427 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000