Protein Alignment Mdr49 and pgp-12

DIOPT Version :10

• Sequence 1: NP_523724.2
• Gene: Mdr49 / 36428
• FlyBaseID: FBgn0004512
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_510126.1
• Gene: pgp-12 / 181415
• WormBaseID: WBGene00004006
• Length: 1318
• Species: Caenorhabditis elegans
• Alignment Length: 1343
• Identity: 456/1343 - (33%)
• Similarity: 722/1343 - (53%)
• Gaps: 143/1343 - (10%)

  Fly    13 GDFQLKEGSVVDATRKYSYFDLFRYSTRCERFLLVVSLLVATAASAFIPYFMIIYGEFTSLLVDR 77
            ||...:|.||...|    ...||||:.|.:..||...:.::..:....|...||.|..|:.|:
 Worm    64 GDLASRELSVKPVT----LLGLFRYAERTDYALLCFGIFLSFISGIAQPGLGIIAGNITNSLL-- 122

  Fly    78 TVGVGTSSPAFALPMFGGGQQLTNASKEENNQAIIDDATAF-GIGSLVGSVAMFLLITLAIDLAN 141
                                 :.||:.::...:.:.:...| |||.:|      |::.....:..
 Worm   123 ---------------------IHNATSDDFYDSAMTNVWLFGGIGIIV------LIVNFVQYMCF 160

  Fly   142 RIALNQI-DRIRKLFLEAMLRQDIAWYDTSSGSNFASKMTEDLDKLKEGIGEKIVIVVFLIMTFV 205
            :....:| .::::.:::::|||:..|:|.:......:|:.::::::.||||:|:.:::..::.||
 Worm   161 QYCCIRITSKMKQHYIQSILRQNAGWFDKNHSGTLTTKLHDNMERINEGIGDKLGVLIRGMVMFV 225

  Fly   206 IGIVSAFVYGWKLTLVVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEEVFSGIRTVFA 270
            .|||.:|.|.|:|.|:::...|......|:::|...|...|||.....|.::.||...|:|||.|
 Worm   226 AGIVISFFYEWRLALMMMGIGPLCCVCMSLMSRSMSSFTSKELAGVGKAGSIAEESLMGVRTVQA 290

  Fly   271 FSGQEKEKERFGKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMALAIWYGVTLILDERDLPDR- 334
            |:|||:..|::...|...::...:|||:.|:...:..|.::......|:||..|:        |
 Worm   291 FNGQEEMVEKYTVELGKGKSFAIQKGLWGGVFGGIFLLFLFSYFGGGIYYGGQLL--------RW 347

  Fly   335 --VYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMDEKGNRPEN 397
              :.||..:.||:.::::||..||..|||:..:..|..|..|::.||||...:|....:|.:..|
 Worm   348 KIIETPGDVFIVVISMLIGAYFLGLISPHLMVLLNARVAAATIYEIIDRTPDIDVYSTEGQKMTN 412

  Fly   398 TAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRFYDPEAGSVK 462
            ..|.:.||.:.||||.|..|::|.||.:.|.||.:||.||.|||||||.:.|:.|.|:||.|.|.
 Worm   413 VVGKVVFEEVHFRYPTRKKVKVLNGLNLTVKPGTSVALVGHSGCGKSTSVGLLTRLYEPEGGKVM 477

  Fly   463 LDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQADIEKAARAANCHDFITRLP 527
            :||:|:|:||:.|||..:|:|.|||:||..||..|:..|.||||:.|:.:..:.||.||||.::|
 Worm   478 IDGQDVRSLNIDWLRKTVGIVQQEPILFNDTIHNNLLIGNPSATREDMIRVCKMANAHDFIQKMP 542

  Fly   528 KGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSALELASQGPTT 592
            .||:|.:|:...|:|||||||:||||.|:|.|:||||||||||||..||..|||||..|::|.||
 Worm   543 NGYETMIGDGSVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESVVQSALNNAAKGRTT 607

  Fly   593 LVVAHRLSTITNADKIVFLKDGVVAEQGTHEELMERRGLYCELVSITQRKEATEADEGAVAGRPL 657
            :::|||||||..||||||.::||:.|.|.||||:...|.|.:||...:.||:
 Worm   608 IMIAHRLSTIREADKIVFFENGVIVESGNHEELVALGGRYAKLVEAQKFKES------------- 659

  Fly   658 QKSQNLSDEETDDDEEDEEEDEEPELQTSG-----SSRDSGFRAS------------------TR 699
                        ||.||..::.|.|..|.|     |||...|..|                  |.
 Worm   660 ------------DDIEDNGDEHEEETSTVGRHDRLSSRQVSFHKSCESLASADLEIGYASTFNTF 712

  Fly   700 RKRRSQRRKKKKD-KEVVSKV---------SFTQLMKLNSPEWRFIVVGGIASVMHGATFPLWGL 754
            ..:.:|...:.:| .|.|.:|         .:..:.|.....:.::.||...:::.|:...|...
 Worm   713 TLKTAQEEIENEDFAEEVQRVMEEDGVINSGYLDIFKNAQGNYLYLSVGTFFAILRGSELALLAN 777

  Fly   755 FFGDFFGILSDGDDDVVRAEVLKISMIFVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTI 819
            .||..|....:.:|::|:|..| |.:::|.:||...:..::...:||.....:..:.|.::|..:
 Worm   778 MFGFVFAAFKEPEDEMVKALGL-IFILYVALGLFVFITQVISGTLFTIVAENLGLKFRVQSFKNL 841

  Fly   820 IGQDIAYFDDERNSVGALCSRLASDCSNVQGATGARVGTMLQAVATLVVGMVVGFVFSWQ----Q 880
            :.||.::||:..::.|.|.:|||||..||:.....|:..::.::.::.:.::.|::|.|:    .
 Worm   842 LYQDASFFDNPAHAPGKLITRLASDAPNVKAVVDTRMLQVIYSITSITINLITGYIFCWRIAIAG 906

  Fly   881 TLLTLVTLPLVCLSVYLEGRFIMKSAQKAKASIEEASQVAVEAITNIRTVNGLCLERQVLDQY-- 943
            |::.::...::....|...|..:|..:|     :||.::|:|.|.:::|:..|...::.|..|
 Worm   907 TIMIVLFATMMISMAYKIARENLKQIRK-----DEAGKIAIEIIESVKTIQLLTSTQRFLTHYKD 966

  Fly   944 ---VQQIDRVDIACRRKVRFRGLVFALGQA----APFLAYGIS--MYYGGILVAEERMNYEDIIK 999
               ||....:     ||...:.:..|:.|.    |.|:.||:.  :.|.||:.|      |...:
 Worm   967 AQLVQHKSEM-----RKSYIQSVNNAISQTFMYFAMFVCYGVGTPLMYHGIVEA------EPTFR 1020

  Fly  1000 VAEALIFGSWMLGQALAYAPNVNDAILSAGRLMDLFKRTSTQPNPPQSPYNTVEKSEGDIVYENV 1064
            ....::.||..:..:....|....|..:||.|..|..|.|...:..:.  |..| ..|::::|:|
 Worm  1021 AINCMMMGSVAVMHSSHNFPEFVKAKTAAGMLFKLIYRKSKTGDVMEG--NNTE-IRGNVLFESV 1082

  Fly  1065 GFEYPTRKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFP 1129
            .|.||.|...|::..|:.:.....|||||||||:|||||:.:|.|:||...|::.:.|.......
 Worm  1083 KFSYPQRPMQPVMTDLHFSAHSGQTVALVGPSGTGKSTCIAMLERFYDVSGGALRIDGQNIKSLS 1147

  Fly  1130 LDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRL 1194
            |..||:::.||.|||.||..||.||:.:|   ..|||::::.:|.:.:|...|::.||.|.||.:
 Worm  1148 LHHLRTQMALVGQEPRLFAGTIKENVCFG---LKDVSVEKVHQALELANASRFLANLPAGIDTEV 1209

  Fly  1195 G-KTSQLSGGQKQRIAIARALVRNPKILILDEATSALDLESEKVVQQALDEARSGRTCLTIAHRL 1258
            | |..||||||||||||||||||:||||:|||||||||.|||:.||:|||.||.||||:||||||
 Worm  1210 GEKGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHRL 1274

  Fly  1259 TTVRNADLICVLKRGVVVEHGTHDELMALNKIYANLYLMQQVS 1301
            ::::|:|||..:..|:|.|.|.|..||:|...|.||...|.::
 Worm  1275 SSIQNSDLIVYIDHGMVQEAGNHAHLMSLRGKYYNLIKKQDLT 1317

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	44..643	CDD:440747	222/603 (37%)
		MdlB	720..1299	CDD:440747	201/594 (34%)
pgp-12	NP_510126.1	MdlB	77..654	CDD:440747	228/617 (37%)
		PTZ00265	145..1312	CDD:240339	432/1228 (35%)