DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr49 and pgp-8

DIOPT Version :9

Sequence 1:	NP_523724.2	Gene:	Mdr49 / 36428	FlyBaseID:	FBgn0004512	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_509811.2	Gene:	pgp-8 / 181277	WormBaseID:	WBGene00004002	Length:	1243	Species:	Caenorhabditis elegans

Alignment Length:	1293	Identity:	432/1293 - (33%)
Similarity:	688/1293 - (53%)	Gaps:	102/1293 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 LFRYSTRCERFLLVVSLLVATAASAFIPYFMIIYGEFTSLLVDRTVGVGTSS--PA---FALPMF 93
            :::.:::.|:||.|:.::.|.......|:....:||.:...|..|..|..:|  |:   .|..||
Worm    28 VWQCTSKWEKFLFVIGVVSAICTGLTQPFMSYTFGEVSQAFVRITAAVNNASLDPSDLEKAYEMF 92

  Fly    94 GGGQQLTNASKEENNQAIIDDATAFGIGSLVGSVAMFLLITLAIDLANRIALNQIDRIRKLFLEA 158
                     ..:.||..|     .||   |||...||... :...|...|..|...|:|..|:..
Worm    93 ---------HADMNNVVI-----HFG---LVGCAFMFFGF-IQFSLFKYIGDNTTYRLRHKFILR 139

  Fly   159 MLRQDIAWYDTSSGSNFASKMTEDLDKLKEGIGEKIVIVVFLIMTFVIGIVSAFVYGWKLTLVVL 223
            :|::|..::||.|....::.:.::|::.:|...|||..::.....|.||...||...|     .|
Worm   140 LLKKDAKYFDTISTGYLSTVLNDNLERFREAFNEKIAFIICFSTDFAIGTALAFYTSW-----TL 199

  Fly   224 SCVPFIIAATSVVARLQGSLA-----EKELKSYSDAANVVEEVFSGIRTVFAFSGQEKEKERFGK 283
            :....:.|...|::.|..|.:     ||:...||:|..:..:.....:||.:.:||.:|.|::..
Worm   200 ASYGSVFAFGIVISGLLNSTSMMKSNEKQSMHYSNAGAIAFQALCSFKTVISLNGQTQELEKYSA 264

  Fly   284 LLIPAENTGRKKGLYSGMGNALSWLIIYLCMAL---AIWYGVTLILDERDLPDRVYTPAVLVIVL 345
            .|...|..|.::..:......||.   :.|.||   .::.|..||.::.       ...|.::.|
Worm   265 ELKEGEKFGSRRAFFLATSRGLSH---FFCNALNGTILYVGADLIYNKT-------MNTVAIVTL 319

  Fly   346 F-AVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMDEKGNRPENT------AGHIR 403
            | .::..|.:||.|..|:..:..|..:...:|:::   :..|.|.|.....|.|      .|.:.
Worm   320 FHYMLFSAFSLGEAFLHISYLLNAINSATPIFDVL---TSDDDMIENNQDNEQTDSNKTIQGMLS 381

  Fly   404 FEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRFYDPEAGSVKLDGRDL 468
            |..::|.||:||||:||:|::.||..|:.:|.|||||.||||::||:..||:.::|::|:....|
Worm   382 FNNVKFAYPSRPDVDILRGISFDVKQGECIALVGASGSGKSTIVQLLLHFYNIQSGTIKIGDSHL 446

  Fly   469 RTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQADIEKAARAANCHDFITRLPKGYDTQ 533
            ..:|:..||:.||||.||||||.|||.||||:|.|:||.::|.:|.|.||.:||:..:..|..|.
Worm   447 HDINLKQLRNAIGVVSQEPVLFNTTIEENIRFGNPNATSSEIYEALRKANAYDFVCNIKDGLKTI 511

  Fly   534 VGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSALELASQGPTTLVVAHR 598
            |||:|||:||||||||||||.||:.|.:|||||||||||..||:.||.||:.||:|.||:::|||
Worm   512 VGERGAQLSGGQKQRIAIARVLVKNPAILLLDEATSALDSASERAVQLALKKASEGRTTIIIAHR 576

  Fly   599 LSTITNADKIVFLKDGVVAEQGTHEELMERRGLYCELV--SITQRKEATEADEGAVAGRPLQKS- 660
            ||||.:.|||:.:.:|.:||.|:||||:.....|..||  .....:...|...|..|...:||:
Worm   577 LSTIRHCDKIMVMSNGKIAEVGSHEELISMDREYSNLVRAQFFDSQSVEEDINGQGAEEVIQKTP 641

  Fly   661 QNLSDEETDDDEEDEEEDEEPELQTSGSSRDSGFRASTRRKRRSQRRKKKKDKEVVSKVSFTQLM 725
            .||:|.|..:           ||....||                      |.|:.|.:  .:::
Worm   642 PNLNDGEPLE-----------ELLKETSS----------------------DIEIKSNI--WEVL 671

  Fly   726 KLNSPEWRFIVVGGIASVMHGATFPLWG-LFFGDFFGILSDGDDDVVRAEVLKISMIFVGIGLMA 789
            :...|:...:.:..|.|.:.|..||:.. :....:.....||::.:......  :.:|:.:|::.
Worm   672 RECRPDAFLLSMAVIGSAIQGCNFPILSQIIVQTYKAYAMDGENILTYGHFW--AAMFLVLGVIR 734

  Fly   790 GLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERNSVGALCSRLASDCSNVQGATGA 854
            .:....|.:.|.....|::||||.::|..::....|::||.::|...|.:||.:|.||::.|..|
Worm   735 PITLYCQFFFFGKVSEKLSTRLRIKSFQHLLSLPCAFYDDPKHSPTRLVNRLNTDPSNIKAAVDA 799

  Fly   855 RVGTMLQAVATLVVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMKSAQKAKASIEEASQV 919
            |:|::|.::.:..:.:::...:||:.||..::..|::..:.:|..:....|.::...:.|.::::
Worm   800 RLGSLLMSMVSFSLAILIACYYSWKLTLQVVLFFPVLYYAKFLYKKTTTISIKEDSVAFENSNKI 864

  Fly   920 AVEAITNIRTVNGLCLERQVLDQYVQQIDRVDIACRRKVRFRGLVFALGQAAPFLAYGISMYYGG 984
            |:|.:.|::||..|.:|.:|::..::.:..:..:..|:....||..........:.|.||..:|.
Worm   865 AIEVLDNMKTVKALNMEARVINLVMEYLAVLKTSYPRRSVVMGLANGFSAGCSQIVYAISFKFGT 929

  Fly   985 ILVAEERMNYEDIIKVAEALIFGSWMLGQALAYAPNVNDAILSAGRLMDLFKRTSTQPNPPQSPY 1049
            .|:.::.:...|:......|.:.|.|.|.|::|.|:...||.|||.:.:||...:|.|....:..
Worm   930 YLILQKEVIPMDMYLSLITLSYTSNMAGSAISYMPDFRKAIHSAGLIFNLFTYPATMPFNSDTGS 994

  Fly  1050 NTVEKSEGDIVYENVGFEYPTRKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDPV 1114
            .::.|  |::..|||.|.|..|....:|..:||.::...|:|:||||||||||.:.||..:|...
Worm   995 RSITK--GEVNGENVKFHYHQRPDYTVLDSVNLKVEAGKTLAIVGPSGSGKSTIISLLEMFYRAD 1057

  Fly  1115 SGSVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNI 1179
            .|.:.:.........||.|||.||||||.||||:.:|.:||.||  ...::|..||..|.:.:|.
Worm  1058 QGFIKIDNDNVENINLDHLRSNLGLVSQGPVLFNCSIRDNILYG--LTRNISQTEIENALQIANA 1120

  Fly  1180 HNFISALPQGYDTRLG-KTSQLSGGQKQRIAIARALVRNPKILILDEATSALDLESEKVVQQALD 1243
            .||:..||||.||.:| :.:||||||||||||.||::||||:|:|||||||||.||||:||.|||
Worm  1121 FNFVFQLPQGLDTIVGDRGAQLSGGQKQRIAITRAILRNPKLLLLDEATSALDTESEKIVQNALD 1185

  Fly  1244 EARSGRTCLTIAHRLTTVRNADLICVLKRGVVVEHGTHDELMALNKIYANLYLMQQVS 1301
            .|....:.:.:||||:|:.|||.|.||:.|.|||.|||::|:|:...|..|...|:.|
Worm  1186 TASERLSTIVVAHRLSTIINADSIAVLRNGKVVEQGTHNQLLAVKGDYWRLVQHQKSS 1243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	34..640	CDD:224055	219/627 (35%)
		ABC_membrane	116..352	CDD:279056	59/244 (24%)
		ABC_MTABC3_MDL1_MDL2	402..636	CDD:213216	126/233 (54%)
		MdlB	735..1299	CDD:224055	194/565 (34%)
		ABC_membrane	739..998	CDD:279056	57/259 (22%)
		ABC_MTABC3_MDL1_MDL2	1059..1298	CDD:213216	119/239 (50%)
pgp-8	NP_509811.2	PTZ00265	29..1241	CDD:240339	430/1288 (33%)
		ABC_membrane	44..326	CDD:294371	74/314 (24%)
		ABC_MTABC3_MDL1_MDL2	382..617	CDD:213216	128/234 (55%)
		ABC_membrane	685..953	CDD:279056	58/269 (22%)
		ABC_MTABC3_MDL1_MDL2	1005..1240	CDD:213216	119/236 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	41	1.000	Domainoid score	I8512
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D216582at33208
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.790