Protein Alignment Mdr49 and mrp-4

DIOPT Version :9

• Sequence 1: NP_523724.2
• Gene: Mdr49 / 36428
• FlyBaseID: FBgn0004512
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_509658.1
• Gene: mrp-4 / 181202
• WormBaseID: WBGene00003410
• Length: 1573
• Species: Caenorhabditis elegans
• Alignment Length: 1416
• Identity: 321/1416 - (22%)
• Similarity: 561/1416 - (39%)
• Gaps: 357/1416 - (25%)

  Fly    34 LFRYSTRCER-----FLLVVSLLVATAASAFI--PYFMIIYGEFTSLLVDRTVGVGTSSPAFALP 91
            |.|::...||     .:|..::..:...|:.:  .||.::|...|.:....|..|
 Worm   366 LIRFTEELERPMWQGVVLAFTMFFSAELSSILLSHYFYLMYRVGTRVQTCLTAAV---------- 420

  Fly    92 MFGGGQQLTNASKEENNQAIIDDATAFGIGSLVGSVAMFLLITLAIDLANRIALNQIDRIRKLFL 156
             :....:|:||::.|..           :|.:|.        .:|||         :||.:::..
 Worm   421 -YRKTLRLSNAARREKT-----------VGEIVN--------LMAID---------VDRFQQITP 456

  Fly   157 EAMLRQDIAWYDTSSGSN-FASKMTEDLDKLKEGIGEKIVIVVFLIMTFVIGIVSAFVYGWKLTL 220
            :.|.    .|      || |                 :|.:.:||:.. .:|:   .|:.....:
 Worm   457 QTMQ----YW------SNPF-----------------QIGLALFLLFQ-QLGV---SVFSGVAVM 490

  Fly   221 VVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEEVFSGIRTVFAFSG--------QEKE 277
            |:|..:.|:|  |.::.:.|  :|:...|  .:...:|.||.:||:.:..::.        ::..
 Worm   491 VLLFPINFVI--TMIIRKWQ--IAQMYYK--DERTKMVNEVLNGIKVIKLYAWEPPMEQVIEDLR 549

  Fly   278 KERFGKLLIPAENTGRKKG----LYSGMGNALSWLIIYLCMALAIWYGVTLILDERDLPDRVYTP 338
            ::..|.:         ||.    .:|.|.|..|..::.|..     :...:.:|    |..|.||
 Worm   550 EQELGLI---------KKAAFLRTFSDMLNTASPFLVALST-----FATFIYID----PKNVLTP 596

  Fly   339 --AVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFN-------IIDRPSQVDPMDEKGNR 394
              |.:.:.||..:        .||..:...:.|...|.:.:       ::.....|:.:|.:. |
 Worm   597 EIAFVSLTLFNQL--------RSPMSQVAELITQTVQVVVSNRRLKEFLVSEELNVEAIDHRA-R 652

  Fly   395 PENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRFYDPEAG 459
            ..|....::...:.:.......|..|..::..|..||.|..||..|.|||:::|.:....:..:|
 Worm   653 DNNDVICLKEACLSWESAEHQPVPTLTNISFSVNRGQLVTIVGRVGAGKSSMLQALMGEMEKLSG 717

  Fly   460 SVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQAD---IEKAARAANCHD 521
            |:.:.||             :..|.|:|.:...|:.:||.:|:    |.|   ..:...|...:.
 Worm   718 SISMHGR-------------LCYVPQQPWMQNNTLRQNITFGK----QFDEYFYSRVLDACALYR 765

  Fly   522 FITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSALELA 586
            .:..||.|.:|::||||..:|||||.||::|||:.:...:.|||:..||:|    ..|.|.|..:
 Worm   766 DLQILPLGDNTEIGEKGINLSGGQKARISLARAVYQNHDIYLLDDPMSAVD----AHVGSQLFGS 826

  Fly   587 SQGP-------TTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELMERRG-----LYCELVSIT 639
            ..||       |.::|.:.||.:..:|.|:.:.:|.:...|.:::||::..     :.||.....
 Worm   827 VIGPEGMLRNKTRILVTNELSFLEKSDLIIVMNEGKIEYSGKYDDLMQQGAFEQLLIECEKEERE 891

  Fly   640 QRKEATEADEGAVAGRPLQKSQNLSDEETDD--------DEEDEEEDE-------EPELQTSGSS 689
            :|:....|||               |:|..:        |.:.|.:|:       :..|.||..|
 Worm   892 RREAEASADE---------------DDENSEPGGIMIGGDSDFEYDDDVMASPIIDHVLGTSHMS 941

  Fly   690 RDSG------FRASTRRKRRSQRRKKKKDKEVVSKVSFTQLMKLNSPE------------WRF-- 734
            ..||      ...||.::||.....|.....:.|  :.||..:|...|            :::
 Worm   942 TVSGIINRRRISTSTHKQRRRLSTTKSHTHSITS--ASTQTRQLTGTERVETGRVKMDTYYKYFG 1004

  Fly   735 ---------IVVGGIASVMHGATFPLWGLFFGDFFGILSD-GDDDVVRAEVLKISM-IFVGIGLM 788
                     .|:|...|.:......||          |:| .:|:..|:....... |.:.:|:.
 Worm  1005 AMGMSIAVLFVLGMTTSTIFSMGRNLW----------LTDWSNDNAARSGSNTTGQPIAIRLGVY 1059

  Fly   789 AGLG---------NMLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERNSVGALCSRLASD 844
            ||||         .||.   ....||..:..|.......:....:|::|  ....|.:.:|:..|
 Worm  1060 AGLGFSEIILLFIGMLS---LLYGGVSASRNLHAPLMRNLFRVPMAFYD--TTPFGRILNRIGKD 1119

  Fly   845 CSNVQGATGARV----GTMLQAVATLVVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMKS 905
            ...|.......|    ..:||.|:||::.|:...||.       :|.:||..:.:.:...:|..|
 Worm  1120 IETVDVLLPFNVQFFAQCLLQVVSTLIIIMISTPVFG-------IVIIPLSVMYLMVMRYYIATS 1177

  Fly   906 AQKAKASIEEASQV------AVEAITNIRT---VNGLC-LERQVLDQYVQQIDRVDIACR--RKV 958
            .|..:......|.:      :::....||.   |:..| |....:|.:||        ||  ..|
 Worm  1178 RQLKRLESITRSPIYSHLSESIQGSATIRAYHLVDRFCKLSETKVDSHVQ--------CRYLNYV 1234

  Fly   959 RFRGLVFALGQAAPFLAYGISMYYGGILVAEERMNYEDIIKVAEALIFGSWMLGQALAYAPNVND 1023
            ..|.|...|            .:.|..:|.     :..:..........|.::|.:::||.|:..
 Worm  1235 ANRWLSVRL------------EFIGNCIVL-----FSALFAALTRTTTTSGVIGLSVSYALNITT 1282

  Fly  1024 A--------------ILSAGRLMDLFKRTSTQ--------PNPPQS-PYNTVEKSEGDIVYENVG 1065
            .              |:|..|:.: :..|.|:        ..|||: |      |||.||..|..
 Worm  1283 VLNFAVRQITKLETNIVSVERVKE-YAETETEAEWKSEPGKEPPQNWP------SEGRIVMNNYS 1340

  Fly  1066 FEYPTRKG-TPILQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFP 1129
            ..|  |.| ..:::.||:.||....|.:||.:|:|||:....|.|..:...|.:.:.|:...|..
 Worm  1341 ARY--RPGLNLVVKQLNVEIKPHEKVGIVGRTGAGKSSVTLSLFRIIEAAEGQIVVDGINLAEIG 1403

  Fly  1130 LDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNIHNFISA--------L 1186
            |..|||.|.::.|:||||..|:..|:...|::.|.    :|.:..:.:|:..|.:|        :
 Worm  1404 LHDLRSNLTIIPQDPVLFSGTLRFNLDPFNHYSDG----DIWKTLEMANLKEFATAHNEQLNYII 1464

  Fly  1187 PQGYDTRLGKTSQLSGGQKQRIAIARALVRNPKILILDEATSALDLESEKVVQQALDEARSGRTC 1251
            .:|.|       .:|.||:|.:.:||||:|..::|||||||:|:|:.::.::|:.:.|..:..|.
 Worm  1465 TEGGD-------NISVGQRQLVCLARALLRKTRVLILDEATAAVDVSTDALIQKTIREEFANATV 1522

  Fly  1252 LTIAHRLTTVRNADLICVLKRGVVVEHGTHDELMALNKIYANLYLMQQVSG 1302
            |||||||.|:.:.|.|.||..|.|.|..:...|  |:...:..|.|.:.:|
 Worm  1523 LTIAHRLNTIMDYDRIIVLNDGKVGEFDSPANL--LSNRNSEFYSMAKRAG 1571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	34..640	CDD:224055	138/649 (21%)
		ABC_membrane	116..352	CDD:279056	46/250 (18%)
		ABC_MTABC3_MDL1_MDL2	402..636	CDD:213216	68/248 (27%)
		MdlB	735..1299	CDD:224055	157/622 (25%)
		ABC_membrane	739..998	CDD:279056	56/285 (20%)
		ABC_MTABC3_MDL1_MDL2	1059..1298	CDD:213216	81/247 (33%)
mrp-4	NP_509658.1	MRP_assoc_pro	17..1572	CDD:188098	321/1416 (23%)
		ABC_membrane	346..613	CDD:294371	63/348 (18%)
		ABCC_MRP_domain1	658..862	CDD:213217	62/224 (28%)
		ABC_membrane	1012..1259	CDD:294371	58/293 (20%)
		ABCC_MRP_domain2	1332..1552	CDD:213211	79/232 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000