Protein Alignment Mdr49 and mrp-6

DIOPT Version :9

• Sequence 1: NP_523724.2
• Gene: Mdr49 / 36428
• FlyBaseID: FBgn0004512
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_001362008.1
• Gene: mrp-6 / 180691
• WormBaseID: WBGene00003412
• Length: 1415
• Species: Caenorhabditis elegans
• Alignment Length: 1429
• Identity: 286/1429 - (20%)
• Similarity: 542/1429 - (37%)
• Gaps: 390/1429 - (27%)

  Fly    30 SYFDL-----FRYSTRCERFLLVVSLLVATAASAFIPYF---------------MIIYGEFTSLL 74
            ||:|:     |.|....: ..|::|||.........|||               :::|.:  ||.
 Worm   147 SYYDIEEGQEFPYWPAMQ-VALIISLLSFVTVCIHHPYFHGLLKVGNHARVATGVLLYRK--SLR 208

  Fly    75 VDRTVGVGTSSPAFALPMFGGGQ--QLTNASKEENNQAIIDDA-----------------TAFGI 120
            :..|....|:|          ||  ||.|....:..||.:...                 :.||.
 Worm   209 ISLTSLFETNS----------GQIIQLLNTDAAKLEQAFLFAHYVWLCPLLMFFYAYILWSMFGF 263

  Fly   121 GSLVGSVAMFLLITLAIDLANRIALNQIDRIRKLFLEAMLRQDIAWYDTSSGSNFASK---MTED 182
            ..|:|.:.|..:::..:..:.::.:|              |::|       |....|:   |:|.
 Worm   264 CCLLGFLVMMAIVSFQVHYSYQLGVN--------------RRNI-------GDKMDSRLKVMSEI 307

  Fly   183 LDKLK--------EGIGEKIVIV----------------VFLIMTFVIGIVSAFVYGWKLTLVVL 223
            ::.:|        ....|||.|:                :.:.:.|:...:..|||       :.
 Worm   308 INGIKVIKMHGWENAFAEKIRILREDEIKAVGTSAFYSSMVMGIYFISAKIGLFVY-------IF 365

  Fly   224 SCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEEVFSGIRTVFA-------------FSGQE 275
            :|..|     ..:...:|..|...|             |:.:|..||             ||...
 Worm   366 ACDYF-----DEILTTRGVFASSAL-------------FNSVRLPFALFLPLGLLFGRELFSTSR 412

  Fly   276 KEK-----ERFGKLLIPAENT-------GRKKGL-YSGMGNALSWLI---------IYLCMALAI 318
            :..     |.:.::.:..::|       ..|:|| ...:|...||.:         ::|....|:
 Worm   413 RIDLFFCLEEYSRITLELDSTDTEDGSKNEKEGLTLKKIGEKPSWTLKCDKAEKTSVFLNKVTAV 477

  Fly   319 WYGVTLILDERDLPDRVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPS 383
            ||.    .||.|...:                 .:|....|.: :|..:|
 Worm   478 WYD----KDEHDQKKK-----------------KKNFKALSDN-DATVIA--------------- 505

  Fly   384 QVDPMDEKGNRPENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQ 448
                 .||.:.|.    |:              |..::.|:.:.:.|.....:|:.|.|||:|:.
 Worm   506 -----GEKKDEPL----HV--------------VYAVQDLSFEFVAGTCYGIIGSVGSGKSSLLL 547

  Fly   449 LMQRFYDPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQADIEKA 513
            .:........|::.::|             ......|||.:|..:|.:||.:| ....:...|.|
 Worm   548 TILSESRMTRGNLSVNG-------------SFAYCAQEPWIFTGSIQDNIVFG-SEFNKERYENA 598

  Fly   514 ARAANCHDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSALDP-TSEK 577
            .........:.:...|..|.||:.|:.:||||:.|:|:|||:.....:.|||:..||:|. ..:|
 Worm   599 LELCLLTPDLRQFANGDMTIVGDNGSTLSGGQRARVALARAVYADADIYLLDDPLSAVDAHVGKK 663

  Fly   578 RVQSALELASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELMERRGLYCELVSITQRK 642
            ..::.:.........::|.|::..::..|.::.:|:..:...|:.:||  :.....:.:.:...:
 Worm   664 LYENLIRGFLSDKLVILVTHQIHFLSELDSVILMKNNKMVGNGSLDEL--KSTFTDDFIKLQAVE 726

  Fly   643 EATEADEGAVAGRPLQ---KSQNLSDEETDDDEEDEEEDEEPELQTSGSSRDSGFRASTRRKRRS 704
            ...::||..|.|.|..   ...|:        |..|:.::|...|.:.|.......:.|...:..
 Worm   727 TEVQSDELFVDGPPSSPPPSPVNI--------ESMEKINKESIFQRANSVLSGSKMSETEYVKEI 783

  Fly   705 QRRKKKK-----------DKEVVSKVSF----------TQLMKLNSPEW---------------- 732
            ....:|.           .:.|::.:.:          ||||. |..:|
 Worm   784 VYESRKSGTISWSVYWEYTRGVINPLKYGIWLVVCVLITQLMN-NFVDWWLNKWLVDLDMNNADN 847

  Fly   733 --------RFIVVGGIASVMHGATFPLWGLFFGDFFGILSDGDDDVVRAEVLKISMIFVGIGLMA 789
                    |.:.|.|..   ...||..:.|.|                         .:...:|:
 Worm   848 STSKEEFNRNVDVLGYT---FNVTFQTYELTF-------------------------IISTVIMS 884

  Fly   790 GLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERNSVGALCSRLASDCSNVQGATGA 854
            .|| ::::..|..|.:..:..|....|..::..:..:||  :||.|.:.:|.:.|.    |.|..
 Worm   885 ILG-VVRSVWFRNAQLMASRILHNSMFDCVLKTESEFFD--KNSEGMILNRFSKDI----GLTDD 942

  Fly   855 RVG-TMLQAV-ATLVVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMKSAQKAKASIEEAS 917
            .:. |..:.| .||....:||.| |..:.::.|....:.....:....::.:|.:..:  ||.|:
 Worm   943 LLAFTYFEFVFGTLTFVGIVGLV-SMVRPIVILACAFITAGFYFCRKMYVHRSRELKR--IEAAA 1004

  Fly   918 QVAVEAITNIRTVNGLCL------ERQVLDQYVQQIDRVDIACRRKVRFRGLVFA--LGQAAPFL 974
            :..:.. |...||:||..      |.::::::....| |.:|...    .||:.|  .|....||
 Worm  1005 RSPLNT-TITSTVHGLSTIRAYRKENEMIEKFCALHD-VYMAAYN----MGLLSARWFGICIDFL 1063

  Fly   975 AYGISMYYG--GILVAEERMNYEDII--KVAEALI-------FGSWMLGQALAYAPNVNDAILSA 1028
               :|::..  .|:|.   :.||.:.  :|...|:       |.||::.|    :..:.:.::|.
 Worm  1064 ---VSVFVSIVAIVVV---LQYETLTVGEVGLCLVCAVQLSGFFSWIMRQ----SAELENGMVSV 1118

  Fly  1029 GRLMDLFK-RTSTQPNPPQSPYNTVEK-------SEGDIVYENVGFEYPTRKGTPILQGLNLTIK 1085
            .|:::..| ::..:...|...|  ::|       ::|:|.:|||...|..   |.:|:.|:..:.
 Worm  1119 ERVLEYTKLKSEEEARRPHDAY--LDKQLLNSWPTKGEIEFENVSVNYGE---TKVLKNLSFVVL 1178

  Fly  1086 KSTTVALVGPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRT 1150
            ....:.:||.:|:||||.::::....:..||.|.:.||......|:..|..:.::.||||:|..|
 Worm  1179 GGQKIGVVGRTGAGKSTLIKIIFGLKEYCSGRVTIDGVDLDHISLNFRRGGMSIIPQEPVIFSGT 1243

  Fly  1151 IAENIAYGNNFRDDVSMQEIIEAAK-KSNIHNFISALPQGYDTRLGKTS-QLSGGQKQRIAIARA 1213
            :.||:...:.: ||.::...:|..: |.:|     ...:|.:..||:.. .||.||:|...:|||
 Worm  1244 VRENLDPFDEY-DDATIWFALEQCELKRSI-----TKEKGLNVELGQRGVSLSVGQRQLFCLARA 1302

  Fly  1214 LVRNPKILILDEATSALDLESEKVVQQALDEARSGRTCLTIAHRLTTVRNADLICVLKRGVVVE 1277
            ::...|||::||||:.:|..::..:|:.:.:.....|.:|:||||.|:.|:|.:.|.::|.:||
 Worm  1303 MIHRSKILVIDEATANVDGVTDACIQKTIRDFFKNATIITVAHRLHTIMNSDNVMVFEKGELVE 1366

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	34..640	CDD:224055	126/707 (18%)
		ABC_membrane	116..352	CDD:279056	47/297 (16%)
		ABC_MTABC3_MDL1_MDL2	402..636	CDD:213216	49/234 (21%)
		MdlB	735..1299	CDD:224055	136/574 (24%)
		ABC_membrane	739..998	CDD:279056	54/270 (20%)
		ABC_MTABC3_MDL1_MDL2	1059..1298	CDD:213216	68/221 (31%)
mrp-6	NP_001362008.1	MRP_assoc_pro	<126..1389	CDD:188098	286/1429 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000