Protein Alignment Mdr49 and mrp-1

DIOPT Version :9

• Sequence 1: NP_523724.2
• Gene: Mdr49 / 36428
• FlyBaseID: FBgn0004512
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_001024719.2
• Gene: mrp-1 / 180409
• WormBaseID: WBGene00003407
• Length: 1534
• Species: Caenorhabditis elegans
• Alignment Length: 1322
• Identity: 306/1322 - (23%)
• Similarity: 566/1322 - (42%)
• Gaps: 270/1322 - (20%)

  Fly   105 EENNQAI---IDDATAFGIGSLVGSV-------AMFLLITLAIDLANRIALNQIDRIRKLFLEAM 159
            |:.||.:   :..|....:.||:.|:       .||           |:.:|    ||.:...|:
 Worm   327 EDKNQPMWIGVSIALLMFLSSLLQSMILHQYFHEMF-----------RLGMN----IRSVLTSAV 376

  Fly   160 LRQDIAWYDTSSGSNFASK----------MTEDLDKLKEGIGEKIVIVVFLIMTFVIGIVSAFVY 214
                  :..|.:.||.|.|          |:.|:.::::     :...:.|..:..:.|:.:..:
 Worm   377 ------YTKTLNLSNEARKGKTTGAIVNLMSVDIQRIQD-----MTTFIMLFWSAPLQILLSLYF 430

  Fly   215 GWKLT--------LVVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEEVFSGIRTVFAF 271
            .|||.        ::::..:||    .|.::....:...:::|...:...::.|:.:|::.:..:
 Worm   431 LWKLLGVSVLAGFVILILLIPF----NSFISVKMRNCQMEQMKFKDERIKMMSEILNGMKVLKLY 491

  Fly   272 SGQEKEKERFGKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMALAIWYGVTLILDERDLPDRVY 336
            | .||..|:....:...|....||..|......|||......:|: :.:|:.::.|..   :.|.
 Worm   492 S-WEKSMEKMVLEVREKEIRVLKKLSYLNAATTLSWACAPFLVAV-LTFGLYVLWDPE---NNVL 551

  Fly   337 TPAVLVIVL------------FAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMD 389
            ||.:..:.|            ||::...             ||..:|..|.........::.|..
 Worm   552 TPQITFVALALFNILRFPLAVFAMVFSQ-------------AVQCSASNTRLKEFFAAEEMSPQT 603

  Fly   390 EKGNRPENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRFY 454
            .......::|  |:.:|..|.:.::.:...|..:|.::..||.||.||..|.|||:|:..:....
 Worm   604 SIAYGGTDSA--IKMDGGSFAWGSKEEDRKLHDITFNIKRGQLVAIVGRVGSGKSSLLHALLGEM 666

  Fly   455 DPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRP---SATQADIEKAARA 516
            :..:|||:::|.......:.|:::             .::..||.:.||   ...|..||..|..
 Worm   667 NKLSGSVQVNGSVAYVPQLAWIQN-------------LSLRNNILFNRPYDAKLYQNVIENCALV 718

  Fly   517 ANCHDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQS 581
            .:    :..||....|::||||..:|||||||:::|||:.:..:::|||:..||:|....|.:..
 Worm   719 QD----LESLPAEDRTEIGEKGINLSGGQKQRVSLARAVYQNAEIVLLDDPLSAVDSHVGKHIFE 779

  Fly   582 ALELASQG----PTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELMERRGLYCELV------ 636
            .:...:.|    .|.:::.|.|:.:.:.|:::.|||..::|.||::|||...|.:.|.:
 Worm   780 NVISTATGCLGTKTRVLLTHGLTYLKHCDQVIVLKDETISEMGTYQELMNSNGAFSEFLEEFLLE 844

  Fly   637 -------SIT---QRKEATE----ADEGAVAGRPLQKSQNLSDEETDDDEEDE------EEDEEP 681
                   |::   ..||..|    .|:.:.|.|...:||...:.|..||:..|      .:||:.
 Worm   845 ESKHKGRSVSFGEDSKEVNELLRDLDQVSPAIRQRIQSQMSQEIEKTDDKNAEIIRNGLHKDEQT 909

  Fly   682 ELQTSGSS--RDSGFRASTRRKRRSQRRKKKK----DKEVV--SKVSFTQLMKLNSPEWRFIVVG 738
            ...:.|.|  ::|...|.:.:::..:..|:.|    :||.|  .||.|...|..      |..:|
 Worm   910 AHSSIGKSEEKESLLGAISPKEKTPEPPKQTKTQLIEKEAVETGKVKFEVYMSY------FRAIG 968

  Fly   739 ----------GIASVMHGATFPLWGLFFGDFFGILSDGDDDVVRAEVLKIS--------MIFVGI 785
                      .:||.|.|.        |.:.:  |:...||   |:.:.:|        .|.:||
 Worm   969 IKIALVFFLVYVASSMLGV--------FSNLY--LARWSDD---AKEIALSGNGSSSETQIRLGI 1020

  Fly   786 GLMAGLG---NMLQTYMFTTAGVKMTTR-LRKRAFGTIIGQDIAYFDDERNSVGALCSRLASDCS 846
            ..:.|:|   ::....:....|:...:| |.......|:...:|:||  ...:|.:.:|...|
 Worm  1021 YAVLGMGQATSVCAASIIMALGMVCASRLLHATLLENIMRSPMAFFD--VTPLGRILNRFGKD-- 1081

  Fly   847 NVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMKSAQKAKA 911
             |.|.......||...:.|.|..:.:..:..|...|...:.|||. :..::..||.:.::::.|
 Worm  1082 -VDGVDTDIPRTMSMFIRTAVSSIEIIAIILWATPLAISLLLPLF-IVYFVVLRFYVSTSRQLK- 1143

  Fly   912 SIEEAS--------QVAVEAITNIRTVNGLCLERQVLDQYVQQID-RVDIACRRKVRFRGLVFAL 967
            .:|.||        |.:::..::||...       |:|:::::.. |||
 Worm  1144 RLESASRSPIYSHFQESIQGASSIRAYG-------VVDKFIRESQHRVD---------------- 1185

  Fly   968 GQAAPFLAYGISMYYGGIL------VAEERMNYEDIIKVAEALIF-------GSWMLGQALAYAP 1019
                    ..::.||..|:      |..|.:....::..|.|.::       .:.::|.:::||.
 Worm  1186 --------ENLATYYPSIVANRWLAVRLEMVGNLIVLSSAGAAVYFRDSPGLSAGLVGLSVSYAL 1242

  Fly  1020 NVNDAILSAGRL-------------MDLFKRTSTQPNPPQSPYNTVEKSEGDIVYENVGFEYPTR 1071
            |:...:..|.|:             ::.:..|.|:.|..||.........|:|..:|....|  |
 Worm  1243 NITQTLNWAVRMTSELETNIVAVERINEYTITPTEGNNSQSLAPKSWPENGEISIKNFSVRY--R 1305

  Fly  1072 KGTP-ILQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFPLDTLRS 1135
            .|.. :|.|:...|.....:.:||.:|:|||:....|.|..:...|.:.:.|....:..|:.|||
 Worm  1306 PGLDLVLHGVTAHISPCEKIGIVGRTGAGKSSLTLALFRIIEADGGCIEIDGTNIADLLLEQLRS 1370

  Fly  1136 KLGLVSQEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRLGKTSQ- 1199
            :|.:|.|:||||..|:..|:.....|.||    :|.||.:.:::.:|:.:|.:|....:.:..:
 Worm  1371 RLTIVPQDPVLFSGTMRMNLDPFFAFSDD----QIWEALRNAHLDSFVKSLQEGLHHHISEGGEN 1431

  Fly  1200 LSGGQKQRIAIARALVRNPKILILDEATSALDLESEKVVQQALDEARSGRTCLTIAHRLTTVRNA 1264
            ||.||:|.|.:||||:|..|:|:||||.:|:|:|::.::|:.:.|.....|.|||||||.||.::
 Worm  1432 LSVGQRQLICLARALLRKTKVLVLDEAAAAVDVETDSLLQKTIREQFKDCTVLTIAHRLNTVMDS 1496

  Fly  1265 DLICVLKRGVVVEHGTHDELMA 1286
            |.:.||.:|.|.|..|..:|::
 Worm  1497 DRLLVLDKGCVAEFDTPKKLLS 1518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	34..640	CDD:224055	128/597 (21%)
		ABC_membrane	116..352	CDD:279056	48/272 (18%)
		ABC_MTABC3_MDL1_MDL2	402..636	CDD:213216	69/240 (29%)
		MdlB	735..1299	CDD:224055	150/611 (25%)
		ABC_membrane	739..998	CDD:279056	55/285 (19%)
		ABC_MTABC3_MDL1_MDL2	1059..1298	CDD:213216	80/230 (35%)
mrp-1	NP_001024719.2	MRP_assoc_pro	23..1531	CDD:188098	306/1322 (23%)
		ABC_membrane	309..570	CDD:294371	50/277 (18%)
		ABCC_MRP_domain1	614..815	CDD:213217	59/217 (27%)
		ABC_membrane	976..1248	CDD:279056	61/322 (19%)
		ABCC_MRP_domain2	1293..1513	CDD:213211	79/225 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000