DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr49 and pgp-9

DIOPT Version :9

Sequence 1:	NP_523724.2	Gene:	Mdr49 / 36428	FlyBaseID:	FBgn0004512	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_507487.1	Gene:	pgp-9 / 180165	WormBaseID:	WBGene00004003	Length:	1294	Species:	Caenorhabditis elegans

Alignment Length:	1310	Identity:	491/1310 - (37%)
Similarity:	738/1310 - (56%)	Gaps:	69/1310 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVKKEESRLPQAGDFQLKEGSVVDATRKYSYFDLFRYSTRCERFLLVVSLLVATAASAFIPYFMI 65
            :.||::......|..:.||.:  ....|.|.|.|:||::..:|.:|.|.::|:.|....:|...|
Worm     3 LFKKKKDDSSSEGSSEKKEEA--PPPPKISIFQLYRYTSTVDRLMLAVGIIVSCATGVGLPLMSI 65

  Fly    66 IYGEFTSLLVDRTVGVGTSSPAFALPMFGGGQQLTNASKEENNQAIIDDATAF---GIGSLVGSV 127
            |.|..:...|  |:|.     .|..|.....::.  |::.|.:..:|.:...:   |.|..   .
Worm    66 IMGNVSQNFV--TLGT-----IFLDPNSTASEKA--AARAEFSHEVIQNCLKYVYLGCGIF---A 118

  Fly   128 AMFLLITLAIDLANRIALNQIDRIRKLFLEAMLRQDIAWYDTSSGSNFASKMTEDLDKLKEGIGE 192
            |.||..:..:.:..:::    :|.|:.|..:::||:|||||.::....::|:.::|::::||.|:
Worm   119 AGFLQASCFMVICEKLS----NRFRRQFFHSVMRQEIAWYDKNTSGTLSNKLFDNLERVREGTGD 179

  Fly   193 KIVIVVFLIMTFVIGIVSAFVYGWKLTLVVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANV 257
            |:.:...::..|:.|...||.|.|.|||:::|..||::.....:|:|..:.|.||.|.|:.|..:
Worm   180 KVGLAFQMMAQFIGGFAVAFTYDWLLTLIMMSLSPFMMICGLFLAKLLATAATKEAKQYAVAGGI 244

  Fly   258 VEEVFSGIRTVFAFSGQEKEKERFGKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMALAIWYGV 322
            .|||.:.||||.||:|||.|.:|:...|...:.||.||....|.|.|..::|||....||.|.|.
Worm   245 AEEVLTSIRTVIAFNGQEYECKRYEDALEHGKKTGIKKSFLIGAGLASFFVIIYASYCLAFWVGT 309

  Fly   323 TLILDERDLPDRVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDP 387
            ..:...|      .....::.|.|:|:||:..||.|......|..|..|..:|:.:|||..::|.
Worm   310 NFVYSGR------LESGTVLTVFFSVMMGSMALGQAGQQFATIGTALGAAASLYEVIDRIPEIDA 368

  Fly   388 MDEKGNRPENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQR 452
            ...:|..|...:|.|....:.|.||.|.||:||||:::|..||||||.||:|||||||:|||:||
Worm   369 YSTEGQTPSKISGRISVNKVEFTYPTRADVKILKGVSLDAQPGQTVALVGSSGCGKSTIIQLLQR 433

  Fly   453 FYDPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQADIEKAARAA 517
            ||:|:||.:.:|...:...|:.:||..:|||.|||.||.|:|.:||||||...:..||.:|.:.|
Worm   434 FYNPDAGQILIDDIPIEDFNIKYLRQLVGVVSQEPNLFNTSIEQNIRYGRSDVSDEDIARALKEA 498

  Fly   518 NCHDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSA 582
            |..|||...|:|.:|.||::|.|:||||||||||||||||.|::|||||||||||..||..||||
Worm   499 NAADFIKTFPEGLNTLVGDRGVQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESESIVQSA 563

  Fly   583 LELASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELMERRGLYCELV------SITQR 641
            ||.||:|.||:|:||||||:.|||||:.:|.|.|.|.||||.|:|::|||.|||      .:..:
Worm   564 LENASRGRTTIVIAHRLSTVRNADKIIVMKAGQVMEVGTHETLIEQKGLYHELVHAQVFADVDDK 628

  Fly   642 KEATEADEGAVAGRPLQKSQNLSDEETDDDEEDEEEDEEPELQTSGSSRDSGFRASTRRKRRSQR 706
            .:..||:..  ..|...:.:...:.:|.:.:.||:....|              |....::..:|
Worm   629 PKKKEAERR--MSRQTSQRKGSVNFKTQESQVDEKPGAPP--------------APEAAEKEIKR 677

  Fly   707 RKKKKDKEVVSKVSFTQLMKLNSPEWRFIVVGGIASVMHGATFPLWGLFFGDFFGILSDGDDDVV 771
            .||:.::|...|.:..::::...|||.:|....||:::.||..|.:.|||.....:.|:.|.|.:
Worm   678 LKKELEEEGAVKANLFKILRYARPEWIYIFFAIIAALIQGAVMPAFSLFFSQIINVFSNPDRDQM 742

  Fly   772 RAEVLKISMIFVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERNSVGA 836
            :.:....:::|:.:..:.|...:.|..:|..|..::|.|:|.:.:..::.||..|||..::|.|.
Worm   743 KKDGHFWALMFLVLAAVQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGR 807

  Fly   837 LCSRLASDCSNVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRF 901
            :.:|||:|..|::.|...|:|::..|:|::..|:.:.|.:.||...|.:...|.:.:...|..::
Worm   808 ITTRLATDAPNIKSAIDYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMMKY 872

  Fly   902 IMKSAQKAKASIEEASQVAVEAITNIRTVNGLCLERQVLDQYVQQIDRVDIACRRKVRFRGLVFA 966
            ...||......:|.|.:.|:|||.|||||..|.|:.::.:.:...:|........|...|||.:.
Worm   873 HGGSATSDAKEMENAGKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAPHGGNISKAIIRGLTYG 937

  Fly   967 LGQAAPFLAYGISMYYGGILVAEER--MNYEDIIKVAEALIFGSWMLGQALAYAPNVNDAILSAG 1029
            ...:..|..|..:..:|..|:.::.  |..|::::|..|:.|....:|.|.:|.|....|..:||
Worm   938 FANSIQFFTYAAAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFAASYFPEYIKATFAAG 1002

  Fly  1030 RLMDLFKR-------TSTQPNPPQSPYNTVEKSEGDIVYENVGFEYPTRKGTPILQGLNLTIKKS 1087
            .:.::.:.       ||:...|..|         |::....|.|.||.|...|||||||:.:|..
Worm  1003 LIFNMLEEEPRIDGMTSSGTYPQLS---------GEVKLNKVFFRYPERPAVPILQGLNVHVKPG 1058

  Fly  1088 TTVALVGPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIA 1152
            .|:|||||||.||||.:.||.|.|||:.|:|.:......:.....||..:.||||||:|||.:|.
Worm  1059 QTLALVGPSGCGKSTVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIR 1123

  Fly  1153 ENIAYGNNFRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRLG-KTSQLSGGQKQRIAIARALVR 1216
            |||.||.. ..:.:.::|..|..|:|||.||..||.||:||:| |.:||||||||||||||||:|
Worm  1124 ENIVYGLQ-PGEYTHEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIR 1187

  Fly  1217 NPKILILDEATSALDLESEKVVQQALDEARSGRTCLTIAHRLTTVRNADLICVLKRGVVVEHGTH 1281
            |||||:|||||||||.||||.||.|||.|...|||:.:||||:|:.||..|.|:|.|.|||.|||
Worm  1188 NPKILLLDEATSALDTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTH 1252

  Fly  1282 DELMALNKIY 1291
            :||:|....|
Worm  1253 NELIAKRGAY 1262

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	34..640	CDD:224055	251/614 (41%)
		ABC_membrane	116..352	CDD:279056	75/238 (32%)
		ABC_MTABC3_MDL1_MDL2	402..636	CDD:213216	139/233 (60%)
		MdlB	735..1299	CDD:224055	216/567 (38%)
		ABC_membrane	739..998	CDD:279056	69/260 (27%)
		ABC_MTABC3_MDL1_MDL2	1059..1298	CDD:213216	131/234 (56%)
pgp-9	NP_507487.1	PTZ00265	28..1262	CDD:240339	485/1281 (38%)
		ABC_membrane	50..334	CDD:279056	90/305 (30%)
		ABC_MTABC3_MDL1_MDL2	383..620	CDD:213216	141/236 (60%)
		ABC_membrane	710..977	CDD:279056	70/266 (26%)
		ABC_MTABC3_MDL1_MDL2	1030..1269	CDD:213216	131/234 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I2660
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	1	1.000	-	-		mtm4744
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R932
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.820