DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mdr49 and haf-3

DIOPT Version :9

Sequence 1:	NP_523724.2	Gene:	Mdr49 / 36428	FlyBaseID:	FBgn0004512	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_506927.2	Gene:	haf-3 / 180056	WormBaseID:	WBGene00001813	Length:	666	Species:	Caenorhabditis elegans

Alignment Length:	629	Identity:	203/629 - (32%)
Similarity:	320/629 - (50%)	Gaps:	49/629 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   690 RDSGFRASTRRKRRSQRR-----KKKKDKEVVSKVSFTQL---MKLNSP-EWRFIVVG----GIA 741
            |.:||..||..|.:...|     :.|::...:...|:..|   :.|..| :|| |::|    ||:
Worm    34 RSTGFLKSTLIKSKQAFRNVSVVETKRESYKLKNASWKDLKAILSLAGPYKWR-IMLGISFLGIS 97

  Fly   742 SVMHGATFPLWGLFFGDFFGILSD------------GDDDVVRAEVLKISMI-FVGIGLMAGLGN 793
            |.:.        ||.....|.|.|            .|..::.|...|.:.| ..|:.::..:..
Worm    98 SSIF--------LFTPRVLGKLIDEWDETKQDKMDPNDKALLLARFFKENPIALAGVFMLGAIAI 154

  Fly   794 MLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERNSVGALCSRLASDCSNVQGATGARVGT 858
            ..:.|...|||..:...|||..|.:::.||:|:||  :|.||.:.|||::|...|..:....:..
Worm   155 AARIYCMHTAGQLVINDLRKSVFNSVLRQDMAFFD--KNKVGEIVSRLSTDALIVGYSVSMNLSD 217

  Fly   859 MLQAVATLV--VGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMKSAQKAKASIEEASQVAV 921
            ..:|:.|..  .|::|  ..|.....:..|.:|::..:..:.|:...|.....:.::..|:|||.
Worm   218 GARALITCFGSGGLMV--YTSLAMCKVIFVVVPVIVGTFAVFGKLQRKYTLMMQEAVAGANQVAT 280

  Fly   922 EAITNIRTVNGLCLERQVLDQYVQQIDRVDIACRRKVRFRGLVFALGQAAPFLAYGISMYYGGIL 986
            |.::::|||..|..||:.|..|..:|:.:....:::...:|.:|...|...:||....::||..|
Worm   281 ERLSSVRTVRMLVAERKELAAYSDKINEIWQISKKEGLAKGFMFGSFQFTGYLALSSILFYGSNL 345

  Fly   987 VAEERMNYEDIIKVAEALIFGSWMLGQALAYAPNVNDAILSAGRLMDLFKRTSTQPNPPQSPYNT 1051
            :::..:.|.::.......:..:..|.....:...:...:.::.||.:|..|   :|..|......
Worm   346 ISQGLLTYGELSSFCLYAVLSAGSLSAMSGFYLELMKGLGASSRLFELKNR---EPRIPLEGGVQ 407

  Fly  1052 VEKSEGDIVYENVGFEYPTRKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDPVSG 1116
            :...:..|.:|:|.|.|..|  .|:...::..:......|:||.|||||||...||||.|||.||
Worm   408 IGNVKDTIRFEHVAFGYADR--DPLFHNISFDVPAGKITAVVGSSGSGKSTIASLLLRLYDPTSG 470

  Fly  1117 SVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNIHN 1181
            .:.:.|....:......|..:|.|.||||||..||.|||.||:...::|:..||:.||.:||...
Worm   471 RILVDGTDLKDIDPSYWRRHIGTVGQEPVLFSTTIKENIIYGSLEPENVTDAEIVSAADQSNADE 535

  Fly  1182 FISALPQGYDTRLGK-TSQLSGGQKQRIAIARALVRNPKILILDEATSALDLESEKVVQQALDE- 1244
            |||..|..|||::|: .|.||||||||||||||||..|.|||:||||||||..||.:|:.||::
Worm   536 FISRFPIKYDTKVGEHGSTLSGGQKQRIAIARALVNKPNILIMDEATSALDASSEYLVRIALNKL 600

  Fly  1245 -ARSGRTCLTIAHRLTTVRNADLICVLKRGVVVEHGTHDELMAL 1287
             |.|.:|.:.|||||:|:::||.|.|:.||.|.|.|::|||:|:
Worm   601 LANSKQTVMIIAHRLSTIKHADQIVVVDRGSVAESGSYDELIAI 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	34..640	CDD:224055
		ABC_membrane	116..352	CDD:279056
		ABC_MTABC3_MDL1_MDL2	402..636	CDD:213216
		MdlB	735..1299	CDD:224055	189/575 (33%)
		ABC_membrane	739..998	CDD:279056	66/273 (24%)
		ABC_MTABC3_MDL1_MDL2	1059..1298	CDD:213216	114/232 (49%)
haf-3	NP_506927.2	MdlB	70..657	CDD:224055	194/593 (33%)
		ABC_membrane	96..366	CDD:279056	65/281 (23%)
		P-loop_NTPase	415..656	CDD:304359	114/232 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910