DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr49 and haf-1

DIOPT Version :9

Sequence 1:	NP_523724.2	Gene:	Mdr49 / 36428	FlyBaseID:	FBgn0004512	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_503098.2	Gene:	haf-1 / 178522	WormBaseID:	WBGene00001811	Length:	677	Species:	Caenorhabditis elegans

Alignment Length:	630	Identity:	190/630 - (30%)
Similarity:	315/630 - (50%)	Gaps:	55/630 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   690 RDSGFRASTRRKRRSQRRKKKKD----------KEVVSKVSFTQLMKLNSPEWRFIVVGGIASVM 744
            ||...:...::..::.||..:::          |::|      :|.::..|..::|.:|....|:
Worm    36 RDLTAKVKNQKLNQNIRRVDRRNAAYLLRHTTWKDLV------ELYEIAKPFRKWIFLGTSFMVV 94

  Fly   745 HGATFPLWGLFFG---DFFGILSDGDDDVVRAE---VLKISMIF-------VGIGLMAGLGNMLQ 796
            ....|.:.....|   |.|    |.:..|.:||   .:||:..|       ||:..:..|....:
Worm    95 SSGIFLIIPRILGKLIDQF----DSNTGVQKAEEVFTMKIAKYFKEQPMSLVGLLAIGALATAAK 155

  Fly   797 TYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERNSVGALCSRLASDCSNVQGATGARVGTMLQ 861
            .|....|||.:...|||..:.:||.||:.:||  :|.||.:.||.|:|...|    |..|.:.|:
Worm   156 VYCLQIAGVNIVGSLRKMVYSSIIRQDMTFFD--KNMVGEIGSRHAADTVIV----GYSVSSSLR 214

  Fly   862 A-VATLVVGM-VVGFVF--SWQQTLLTLVTLPLVCLSVYLEGRFIMKSAQKAKASIEEASQVAVE 922
            | |..::||: .:|.:.  |.:.:.::.:|.|:|.....:.||...:...:.:....:.:|.|:|
Worm   215 AGVRAVLVGVGSIGMMLMTSLELSTVSFLTAPIVMGIFKMFGRVQQQCTWQLQEVAADVNQTAIE 279

  Fly   923 AITNIRTVNGLCLERQVLDQYVQQIDRVDIACRRKVRFRGLVFALGQAAPFLAYGISMYYGGILV 987
            .:.|::|:..|..|:|.:|:|.::.:.|....:.:...:|.:....|...:.|:...::||..|:
Worm   280 RMANMKTIRMLSAEQQSIDEYCKKGELVLDISKTEALAKGSLIGSFQFTGYSAFSSILFYGSHLI 344

  Fly   988 AEERMNYEDIIKVAEALIFGSWMLGQALAYAPNVNDAILSAGRLMDLFKRTSTQPNPPQSPYNTV 1052
            ....:.|.::.......:..:..|.....:...|...:.::.||::|     ....|..:..:.:
Worm   345 NTGHITYGELSSFCLYAVLAAASLSNISGFYNEVMKGLGASSRLLEL-----KNAQPIMNLNSGI 404

  Fly  1053 EKSE--GDIVYENVGFEYPTRKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDPVS 1115
            :|::  ..|.:|||.|.|..||.|  |:.::..|.:....|::||||||||:...|:||.|||..
Worm   405 KKTDITTSIQFENVSFAYAGRKKT--LENISFDIPRGKITAVIGPSGSGKSSIANLMLRLYDPAD 467

  Fly  1116 GSVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNIH 1180
            |.|.:.||...:....|.|..:|.|.||||||..:|.|||..|....:.||..|:.|||:.:|..
Worm   468 GRVTVDGVDLRDLNATTWRHAIGTVGQEPVLFTCSIRENILMGTEHPEKVSQYELEEAAQLANAL 532

  Fly  1181 NFISALPQGYDTRLGKTS-QLSGGQKQRIAIARALVRNPKILILDEATSALDLESEKVVQQALDE 1244
            :||.....|::|.:|:.. :|||||||||||||||:..|||:||||||||||..|:.:::..||.
Worm   533 DFIQGFENGFETMVGEHGCKLSGGQKQRIAIARALISKPKIMILDEATSALDATSDYLIRMTLDN 597

  Fly  1245 ARSGR--TCLTIAHRLTTVRNADLICVLKRGVVVEHGTHDELMAL 1287
            .....  |.|.|||||.|::.||.:..:.||.:...||.||:|.:
Worm   598 LLKNHNLTVLVIAHRLATMQQADQVVYVNRGRIEGQGTFDEMMKI 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	34..640	CDD:224055
		ABC_membrane	116..352	CDD:279056
		ABC_MTABC3_MDL1_MDL2	402..636	CDD:213216
		MdlB	735..1299	CDD:224055	182/575 (32%)
		ABC_membrane	739..998	CDD:279056	68/275 (25%)
		ABC_MTABC3_MDL1_MDL2	1059..1298	CDD:213216	105/232 (45%)
haf-1	NP_503098.2	MdlB	82..641	CDD:224055	181/575 (31%)
		ABC_membrane	93..363	CDD:294371	68/279 (24%)
		P-loop_NTPase	413..641	CDD:304359	104/229 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910