Protein Alignment Mdr49 and hmt-1

DIOPT Version :10

• Sequence 1: NP_523724.2
• Gene: Mdr49 / 36428
• FlyBaseID: FBgn0004512
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_001022812.1
• Gene: hmt-1 / 176540
• WormBaseID: WBGene00001815
• Length: 801
• Species: Caenorhabditis elegans
• Alignment Length: 657
• Identity: 181/657 - (27%)
• Similarity: 311/657 - (47%)
• Gaps: 112/657 - (17%)

  Fly   688 SSRDSGFRASTRRKRRSQRRKKKKDKEVVSKVSFTQLMKLNSPEWR------FIVVGGIASVMHG 746
            |||:|.:              ....|:||:...:....|..|.:.|      .:::|.:.:|
 Worm   195 SSRESAW--------------NNLSKKVVTVAPYIWPTKSISLQLRVVFCLFLLIIGRLINV--- 242

  Fly   747 ATFPL---WGLFFGDFFGILSDGDDDVVRAEVLKISMIFV--------GIGLMAGLGNMLQTYMF 800
             :.|:   |.:             |::...:..:.|::|:        |.|.|.|..|.::||::
 Worm   243 -SLPILSKWIV-------------DELATPDTFQYSLLFLATFLKFLQGNGAMGGFLNTVRTYLW 293

  Fly   801 TTAGVKMTTRLRKRAFGTI------------IGQDIAYFDDERNSVGALCSRLASDCSNVQGATG 853
            .......|..|....|..:            .||.:...|...:||..:.:.:
 Worm   294 IPIQQYTTRELEVELFKHLHSLSLRWHLSRKTGQVLRVMDRGTSSVNNILNYI------------ 346

  Fly   854 ARVGTMLQAVATLVVGMVVGF-VFSWQQTLLTLVTLPL---VCLSVYLEGR--FIMKSAQKAKAS 912
              :..::..:|.:|:.::..| .|:....|:...|:.|   |.:|: .|.|  :|.::.:|..|:
 Worm   347 --LFNVVPTIADIVIAVIFFFSAFNAYFGLIVFGTMALYLTVTISI-TEWRTQYIREANEKDNAT 408

  Fly   913 IEEASQVAVEAITNIRTVNGLCLERQVLDQYVQQIDRVDIACRRKVRFRGLVFALGQAAPFLAYG 977
                |.:|.:::.|..||.....|...::::...|:...:...:.......:..|..|    ..|
 Worm   409 ----SAIATDSLINYETVKYYGNEEFEVNRFKNAIESYQVTEWKTQASLAFLNCLQNA----IIG 465

  Fly   978 ISMYYGGILVAEERMNYEDIIKVAEALIFGSWMLGQALAYAP---------NVNDAILSAGRLMD 1033
            |.|..|.:.|. ..:.:|..:.|.:.::|.:::|   ..|.|         .:..|.:....:.|
 Worm   466 IGMIGGSVFVV-YMIVHEKTLTVGDYVLFTTYLL---QLYTPLNFFGTIYRVIQKAFVDMENMFD 526

  Fly  1034 LFK-RTSTQPNPPQSPYNTVEKSEGDIVYENVGFEYPTRKGTPILQGLNLTIKKSTTVALVGPSG 1097
            |.. ....:..|...||.   ...|.|..:|:.|||.|  |.|:::.::..|....||||||.||
 Worm   527 LMNDEVEVKDLPHALPYT---DPRGTISVKNLTFEYNT--GLPVIKNISFEIGNGQTVALVGSSG 586

  Fly  1098 SGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFR 1162
            |||||.::||.|.::...||:...|:....:.:.:||.::|:|.|:.|||:.||..||.:|   |
 Worm   587 SGKSTLIRLLFRLFESTEGSIEFDGIDVRNYTMHSLRQQIGIVPQDTVLFNDTIMYNIRFG---R 648

  Fly  1163 DDVSMQEIIEAAKKSNIHNFISALPQGYDTRLGKTS-QLSGGQKQRIAIARALVRNPKILILDEA 1226
            .|.|.:|:|||||.:.||..|::||:||.|.:|:.. :||||:|||:||||.:::.|:.:.||||
 Worm   649 PDASDEEVIEAAKAAMIHEKITSLPEGYATMVGERGLKLSGGEKQRVAIARTILKKPQFIFLDEA 713

  Fly  1227 TSALDLESEKVVQQALDEARSGRTCLTIAHRLTTVRNADLICVLKRGVVVEHGTHDELMALNKIY 1291
            |||||..:|:.:|:.|::....||.:.:||||:||.|||||.||.:|:::|.|.|.||:|....|
 Worm   714 TSALDTPTERAIQKCLEKLCKSRTGVVVAHRLSTVVNADLILVLDKGIILERGNHKELLAQQGTY 778

  Fly  1292 ANLYLMQ 1298
            |:::..|
 Worm   779 ASMWEAQ 785

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	44..643	CDD:440747
		MdlB	720..1299	CDD:440747	174/625 (28%)
hmt-1	NP_001022812.1	ATM1	213..791	CDD:444078	174/625 (28%)