DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mdr49 and haf-9

DIOPT Version :9

Sequence 1:	NP_523724.2	Gene:	Mdr49 / 36428	FlyBaseID:	FBgn0004512	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_491754.1	Gene:	haf-9 / 172288	WormBaseID:	WBGene00001819	Length:	815	Species:	Caenorhabditis elegans

Alignment Length:	710	Identity:	237/710 - (33%)
Similarity:	352/710 - (49%)	Gaps:	100/710 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KKEESRLPQAGDFQLKEGSVVDATRKYSYFDLFRYSTRCERFLLVVSLLVATAASAFIPYFMIIY 67
            ::.|....|...|||....:....|::.|:.:..:      ||...||     :..||||:.
Worm   176 EEAEKAAEQRETFQLLFRLLGYMGRQWKYYGMAFF------FLFCYSL-----SRVFIPYYT--- 226

  Fly    68 GE-FTSLLVDRTVGVGTSSPAFALPMFGGGQQLTNASKEENNQAIIDDATAFGIGSLVGSVAMFL 131
            || .|::..|:..........|.:.|      |:.||            |.|| |...||..
Worm   227 GEVVTAVFGDKASYEKLHKTVFIMGM------LSLAS------------TVFG-GLRGGSFT--- 269

  Fly   132 LITLAIDLANRIALNQIDR-IRKLFLEAMLRQDIAWYDTSSGSNFASKMTEDLDKLKEGIGEKIV 195
                       .|...||| ||.....::::|:|.::|.:......|:::.|...:...: ...:
Worm   270 -----------YAHATIDRQIRNDLFRSVVKQEIGFFDMNKTGEICSRLSADCQTMSNTL-SLYM 322

  Fly   196 IVVFLIMTFVIG-IVSAFVYGWKLTLVVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVE 259
            .|:...:|.:.| ::..|...|||:::.|..:|.|.....:.......|:|:...|.:.|.:|.|
Worm   323 NVLTRNLTMLFGSLIFMFTLSWKLSMITLINIPIIFLVNKIFGVWYDMLSEETQNSVAKANDVAE 387

  Fly   260 EVFSGIRTVFAFSGQEKEKERFGKLL-IPAENTGRKKGLYSGMGNALSW---LIIYLCMALAIWY 320
            ||.|.||||.:|:.:..|..||...| :..:...||..:..|    |.|   |:....:.:.:||
Worm   388 EVLSSIRTVKSFACENYESSRFMTFLNVTLKIATRKVFVVIG----LIWSNELLQMGILTIVLWY 448

  Fly   321 GVTLILDERDLPDRVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQV 385
            |..|:::     ::|.:..::..:|:...:| :||.........:..|..|.:.:|..||||.:|
Worm   449 GGHLVIE-----NKVESGLLVSFLLYQFQLG-ENLRELGEVWNGLMQAVGASRKVFEFIDRPPRV 507

  Fly   386 DPMDEKGN-RPENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQL 449
               :..|. .|:...|.|.|..:.|.||.|||:.|::.||..|.||:.||.||.||.|||:.|.:
Worm   508 ---ENTGTYAPDGMTGKIEFRHVAFSYPIRPDLPIMEDLTFTVEPGEVVALVGPSGGGKSSCIAM 569

  Fly   450 MQRFYDPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQADIEKAA 514
            ::.||:|.:|.|.:||..:|..:..:|.:::.:|||||||:|.::.|||.||........::.:|
Worm   570 LEHFYEPTSGEVLIDGVPVREYDHKFLHTKVALVGQEPVLYARSVTENIGYGLDKYDDDMVQNSA 634

  Fly   515 RAANCHDFITR-LPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKR 578
            :.||.|.||.. ...||:|.|||||:|:||||||||||||||||||.||||||||||||..||..
Worm   635 KLANAHTFIMNDTTDGYNTNVGEKGSQMSGGQKQRIAIARALVRQPVVLLLDEATSALDAESEHT 699

  Fly   579 VQSALELASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELMERRGLYCELVSITQRKE 643
            ||.|:....:|.|.:::||||||:.||||||.:..|.|.:.|.|:.|||:.|||.:||   ||
Worm   700 VQEAISKNLKGKTVILIAHRLSTVENADKIVVINKGKVEQLGNHKTLMEQEGLYKQLV---QR-- 759

  Fly   644 ATEADEGAVAGRPLQKSQNLSDEETDDDEEDEEEDEEPE-LQTSGSSRDSGFRASTRRKR 702
                             |.:|.|:..||     |.|||| .:..||.|.:  ||..||.|
Worm   760 -----------------QMMSGEDGLDD-----EIEEPEPAREGGSGRST--RAGARRIR 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	34..640	CDD:224055	210/614 (34%)
		ABC_membrane	116..352	CDD:279056	57/241 (24%)
		ABC_MTABC3_MDL1_MDL2	402..636	CDD:213216	120/234 (51%)
		MdlB	735..1299	CDD:224055
		ABC_membrane	739..998	CDD:279056
		ABC_MTABC3_MDL1_MDL2	1059..1298	CDD:213216
haf-9	NP_491754.1	3a01208	19..757	CDD:273363	215/641 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810