Protein Alignment Mdr49 and haf-6

DIOPT Version :9

• Sequence 1: NP_523724.2
• Gene: Mdr49 / 36428
• FlyBaseID: FBgn0004512
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_490828.3
• Gene: haf-6 / 171694
• WormBaseID: WBGene00001816
• Length: 668
• Species: Caenorhabditis elegans
• Alignment Length: 542
• Identity: 208/542 - (38%)
• Similarity: 303/542 - (55%)
• Gaps: 52/542 - (9%)

  Fly   126 SVAMFLLITLAIDLANRIALNQIDRIRKLFLEAMLRQDIAWYDTSSGSNFASKMTEDLDKLKEGI 190
            |...||.||....|..|:|    .::|....:.:|..|:|::|:......::::..|:.:.|...
 Worm   159 SALTFLYITFLTVLGERMA----TKMRSDLFQKLLHHDMAFFDSHKSGELSARLNADVQEFKSSF 219

  Fly   191 GEKIVIVVFLIMTF--VIGIV-SAFVYGWKLTLVVLSCVPFIIAATSVVARLQGSLAEKELKSYS 252
              |:.:...| .||  .||.: |.:.....:|:..::.||.||.|.|.:......|:.:.....:
 Worm   220 --KLCVSQGL-RTFAQTIGCIGSLYFLSPTMTMYTVAVVPGIILAGSAIGAGLRQLSRRAQGQSA 281

  Fly   253 DAANVVEEVFSGIRTVFAFSGQEKEKERFGKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMALA 317
            .|:.|.:|..:.|||:.||:.::.|...|...|..|.....:.|:..|:..|.:.|.:. .|.|:
 Worm   282 TASAVSDEALTNIRTIRAFAMEKLESRLFDNELDKARAMQEQLGVGIGLFQAGTNLFLN-GMILS 345

  Fly   318 IWYGVTLILDERDLPDRVYTPAVLVIVL------------FAVIMGAQNLGFASPHVEAIAVATA 370
            :.||.:.::.:.::     ||..|:..|            .::|.|.           ||...||
 Worm   346 VLYGGSNLISKGEM-----TPGALMSFLVSAQTIQRSLSQLSIIFGT-----------AIKGWTA 394

  Fly   371 AGQTL-FNIIDRPSQVDPMDEKGNRPENTA-GHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTV 433
            .|:.| |:.:: ||  .|||.....|.::. |.|:||.:.|.||.||...:.:.||:.:..||.|
 Worm   395 GGRVLQFSRLE-PS--IPMDTGVCIPYHSLWGDIKFEDVSFSYPTRPGHTVFENLTLSIPAGQVV 456

  Fly   434 AFVGASGCGKSTLIQLMQRFYDPEAGSVKLDGRDLRTLNVGWLRSQ-IGVVGQEPVLFATTIGEN 497
            |..|.||.||||:..|::|||:|::|.|.|||||||.|||.|||.| ||::.||||||||::.||
 Worm   457 ALCGPSGEGKSTITHLLERFYEPKSGRVTLDGRDLRELNVEWLRGQVIGLISQEPVLFATSVEEN 521

  Fly   498 IRYGRPSATQADIEKAARAANCHDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVL 562
            ||||||.||..::.:|||||:..:|::|.|.||.|.|||:|||:|||||||||||||:::.|.:|
 Worm   522 IRYGRPDATDEEVREAARAAHVDEFVSRFPSGYSTVVGERGAQLSGGQKQRIAIARAILKNPPIL 586

  Fly   563 LLDEATSALDPTSEKRVQSALELASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELME 627
            :|||||||||..||..||.||....:|.|.|::|||||||.:|..|..:||....|.||||:||.
 Worm   587 ILDEATSALDSHSEHMVQEALNNVMKGRTVLIIAHRLSTIRSAQMIYVIKDKKALESGTHEQLMA 651

  Fly   628 RRG-LYCELVSITQRKEATEAD 648
            ::| ||.:||      ||...|
 Worm   652 KKGSLYRKLV------EAHNVD 667

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	34..640	CDD:224055	205/532 (39%)
		ABC_membrane	116..352	CDD:279056	55/240 (23%)
		ABC_MTABC3_MDL1_MDL2	402..636	CDD:213216	133/235 (57%)
		MdlB	735..1299	CDD:224055
		ABC_membrane	739..998	CDD:279056
		ABC_MTABC3_MDL1_MDL2	1059..1298	CDD:213216
haf-6	NP_490828.3	MdlB	87..663	CDD:224055	205/536 (38%)
		ABC_membrane	102..378	CDD:279056	54/231 (23%)
		ABC_MTABC3_MDL1_MDL2	425..663	CDD:213216	135/243 (56%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	191	1.000	Domainoid score	I1905
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910