DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mdr49 and haf-4

DIOPT Version :9

Sequence 1:	NP_523724.2	Gene:	Mdr49 / 36428	FlyBaseID:	FBgn0004512	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_001021666.1	Gene:	haf-4 / 171639	WormBaseID:	WBGene00001814	Length:	787	Species:	Caenorhabditis elegans

Alignment Length:	641	Identity:	216/641 - (33%)
Similarity:	313/641 - (48%)	Gaps:	62/641 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SRLPQAGDFQLKEGSVVDATRKYSYFDLFRYSTRCER-FLLVVS----LLVATAASAFIPYFMII 66
            ||.|.:  :.:.|...::...|.::..:||....|:| :|..:|    |.:.:....|:||:.
Worm   143 SRTPSS--YIILEDEDLEVAPKQTFELIFRLLQYCKREWLWHISGFSWLFIYSITRIFVPYYT-- 203

  Fly    67 YGEFTSLLVDRTVGVGTSSPAFALPMFGGGQQLTNASKEENNQAIIDDATAFGIGSLVGSVAMFL 131
             |:     |..||....|.||           |:||   .....||...:|...|...||.
Worm   204 -GQ-----VIATVVATKSYPA-----------LSNA---VYIMTIISLVSAVAAGFRGGSF---- 244

  Fly   132 LITLAIDLANRIALNQIDR-IRKLFLEAMLRQDIAWYDTSSGSNFASKMTEDLDKLKEGIGEKIV 195
                      ..|..:|.| ||......:::||:|:||........|::..|...:.:.:...:.
Worm   245 ----------EYAYARIQRAIRYDLFHGLVKQDVAFYDAHKTGEVTSRLAADCQTMSDTVALNVN 299

  Fly   196 IVVFLIMTFVIGIVSAFVYGWKLTLVVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEE 260
            :.:...:..:..::......|:|:||....||.|..|:.:.......|:|:...:.:::.:|.||
Worm   300 VFLRNCVMLLGSMIFMMKLSWRLSLVTFILVPIIFVASKIFGTYYDLLSERTQDTIAESNDVAEE 364

  Fly   261 VFSGIRTVFAFSGQEKEKERF-GKLLIPAENTGRKKGLYSGMGNALSW---LIIYLCMALAIWYG 321
            |.|.:|||.:||.:..|.:|| |||....:.|..|...|.|    ..|   |.....:...:|||
Worm   365 VLSTMRTVRSFSCENVEADRFYGKLTHTLDVTRTKAIAYIG----FLWVSELFQSFIIVSVLWYG 425

  Fly   322 VTLILDERDLPDRVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVD 386
            ..|:|.::...|      :||..|...:....||.........:..:..|.:.:|..|||..|:.
Worm   426 GHLVLTQKMKGD------LLVSFLLYQMQLGDNLRQMGEVWTGLMQSVGASRKVFEYIDREPQIQ 484

  Fly   387 PMDEKGNRPENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQ 451
            ...|  ..|||..|.|.|..:.|.||.|.|..|||.|:..|.||:|||.||.||.|||:.|.|::
Worm   485 HNGE--YMPENVVGKIEFRNVHFSYPTRSDQPILKDLSFTVEPGETVALVGPSGSGKSSCISLLE 547

  Fly   452 RFYDPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQADIEKAARA 516
            .||.|.||.|.:||..|......::..:|.:|||||||||.::.||:||| ......:|.::...
Worm   548 NFYVPNAGQVLVDGVPLEEFEHHYIHKKIALVGQEPVLFARSVMENVRYG-VEVADTEIIRSCEM 611

  Fly   517 ANCHDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQS 581
            ||.|.||.:....|:|.|||||.|:||||||||||||||||:|.:|||||||||||..||..||.
Worm   612 ANAHGFIMQTTLKYETNVGEKGTQMSGGQKQRIAIARALVREPAILLLDEATSALDTESEHLVQE 676

  Fly   582 ALELASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELM-ERRGLYCELV 636
            |:.....|.:.:::||||||:..|||||.:..|.|.:.|.||.|: :..|.|.:||
Worm   677 AIYKNLDGKSVILIAHRLSTVEKADKIVVINKGRVEQIGNHETLLKDTNGTYAKLV 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	34..640	CDD:224055	211/614 (34%)
		ABC_membrane	116..352	CDD:279056	57/240 (24%)
		ABC_MTABC3_MDL1_MDL2	402..636	CDD:213216	117/234 (50%)
		MdlB	735..1299	CDD:224055
		ABC_membrane	739..998	CDD:279056
		ABC_MTABC3_MDL1_MDL2	1059..1298	CDD:213216
haf-4	NP_001021666.1	3a01208	16..732	CDD:273363	214/639 (33%)
		ABC_membrane	189..449	CDD:279056	73/305 (24%)
		ABC_MTABC3_MDL1_MDL2	498..735	CDD:213216	119/236 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810