DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mdr49 and Abcc2

DIOPT Version :9

Sequence 1:NP_523724.2 Gene:Mdr49 / 36428 FlyBaseID:FBgn0004512 Length:1302 Species:Drosophila melanogaster
Sequence 2:NP_038834.2 Gene:Abcc2 / 12780 MGIID:1352447 Length:1543 Species:Mus musculus


Alignment Length:1287 Identity:291/1287 - (22%)
Similarity:537/1287 - (41%) Gaps:282/1287 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   151 IRKLFLEAMLRQDIAWYDTSSGSNFASKMTEDLDKLKEGIGEKIVIVVFLIMTFVIGIVSAFVYG 215
            |..::.:|:...::|....:.|.. .:.|:.|..||.:     :...:.|:.:.|:.|..:..:.
Mouse   395 IASVYKKALTLSNLARRQYTIGET-VNLMSVDSQKLMD-----VTNYIHLLWSSVLQIALSIFFL 453

  Fly   216 WKLTLVVLSCVPFIIAATSVVARL---QGSLAEK-------ELKSYSDAANVVEEVFSGIRTVFA 270
            |:      ...|.|:|...::..|   .|.||.|       .:|:......::.|:.|||:.:..
Mouse   454 WR------ELGPSILAGVGLMVLLVPVNGVLATKIRKIQVQNMKNKDKRLKIMNEILSGIKILKY 512

  Fly   271 FSGQEKEKERFGKLLIPAENTGRKKGLYSGMG-NALSWLIIYLCMALAIWYGVTLILDERDLPDR 334
            |:.:...||:.        |:.|||.|.:.:. :.|..::|::..                    
Mouse   513 FAWEPSFKEQV--------NSIRKKELRNLLRFSQLQTILIFILH-------------------- 549

  Fly   335 VYTPAVLVIVLFA--VIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPM--------D 389
             .||.::.::.|:  |::.:||:..|.....:|        |||||:..|..:.||        .
Mouse   550 -LTPTLVSVITFSVYVLVDSQNVLNAEKAFTSI--------TLFNILRFPLAMLPMVISSVIQAS 605

  Fly   390 EKGNRPENTAGH-----------------IRFEGIRFRYPARPDVE-ILKGLTVDVLPGQTVAFV 436
            ...:|.|...|.                 ::|....|.:..  |:| .::.:.:|:.|||.||.|
Mouse   606 VSVDRLEQYLGSDDLDLSAIRHVCHFDKAVQFSEASFTWDR--DLEATIQDVNLDIKPGQLVAVV 668

  Fly   437 GASGCGKSTLIQLMQRFYDPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYG 501
            |..|.|||:||..|....:...|.:.:.|             .|..|.|:..:...||.:||.:|
Mouse   669 GTVGSGKSSLISAMLGEMENVHGHITIKG-------------SIAYVPQQAWIQNGTIKDNILFG 720

  Fly   502 RPSATQADIEKAAR---AANCHDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLL 563
                ::.|.:|..|   |......:..||.|...::||||..:|||||.|:::|||..:...:.:
Mouse   721 ----SEYDEKKYQRVIEACALLPDLEMLPGGDMAEIGEKGINLSGGQKHRVSLARATYQDADIYI 781

  Fly   564 LDEATSALDPTSEKRVQSAL----ELASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEE 624
            ||:..||:|....|.:.:.:    .|.| |.|.::|.|.:..:...|:||.|..|.:.|:|::.:
Mouse   782 LDDPLSAVDTHVGKHIFNKVVGPNGLLS-GKTRILVTHGIHFLPQVDEIVVLGKGTILEKGSYSD 845

  Fly   625 LMERRGLYCELVSITQRKEATEADEGAVAGRPLQKSQNLSDEETDDDEEDEEE---------DEE 680
            ||:::|::                  |...:...|......|.|.|::.:||:         :|.
Mouse   846 LMDKKGVF------------------AKNWKTFMKHSGPEGEATVDNDSEEEDGDCGLIPTVEEI 892

  Fly   681 PELQTS-GSSRDSGFRASTRRKRRSQRRKKK---------------KDKEVV------------- 716
            |:...| ...|::..|.:..|..||..|:.|               |.:|||             
Mouse   893 PDDAASLTMRRENSLRRTLSRSSRSGSRRGKSLKSSLKIKSVNALNKKEEVVKGQKLIKKEFVET 957

  Fly   717 SKVSFTQLMK-LNSPEWRFIVVGGIASVMHGATFPLWGLFFGDFFGILS---------------- 764
            .||.|:..:| |.:..|                   |.|.|...|.:|:                
Mouse   958 GKVKFSIYLKYLQAVGW-------------------WSLLFIVIFYVLNYVAFIGTNLWLSAWTS 1003

  Fly   765 -----DGDDDVVRAEVLKISMIFVGIGLMAGLGNMLQTYMFTTAGVKMTTR-LRKRAFGTIIGQD 823
                 :|.|:......::|. :|..:|:..|: .:|.:.:::....:..:: |.::....|:...
Mouse  1004 DSEKQNGTDNSPSQRDMRIG-VFGALGIAQGI-FLLSSSLWSIYACRNASKTLHRQLLTNILRAP 1066

  Fly   824 IAYFDDERNSVGALCSRLASDCSNVQGATGARVGTMLQA----VATLVVGMVVGFVFSWQQTLLT 884
            :::||  ....|.:.:|.|.|.|.|.......:.:.|..    |:|||:..:...:|       .
Mouse  1067 MSFFD--TTPTGRIVNRFAGDISTVDDTLPQTLRSWLLCFFGIVSTLVMICMATPIF-------I 1122

  Fly   885 LVTLPLVCLSVYLEGRFIMKSAQKAKASIEEASQV---AVEAITNIRTVNGLCLERQVLDQYVQQ 946
            ::.:||..|.|.::..::..|.|..:......|.:   ..|.::.:..:.....:::.|....:|
Mouse  1123 IIIIPLSILYVSVQVFYVATSRQLRRLDSVTKSPIYSHFSETVSGLPVIRAFEHQQRFLANSEKQ 1187

  Fly   947 IDRVDIACRRKVRF------RGLVFAL---GQAAPFLAYGISMYYGGILVAEE-RMNYEDIIKVA 1001
            ||     ..:|..|      |.|...|   |....|.:..:.:.|...|..:. .....:.:.:.
Mouse  1188 ID-----TNQKCVFSWITSNRWLAIRLELVGNLIVFCSALLLVIYKNSLTGDTVGFVLSNALNIT 1247

  Fly  1002 EALIFGSWMLGQALAYAPNVNDAILSAGRLMDLFKRTSTQPNPPQSPYNTVEK------SEGDIV 1060
            :.|   :|:    :.....|...|::..|:.:.....:      ::|:.|.:|      .:|:|.
Mouse  1248 QTL---NWL----VRMTSEVETNIVAVERINEYINVDN------EAPWVTDKKPPADWPKKGEIQ 1299

  Fly  1061 YENVGFEYPTRKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPS 1125
            :.|....|...... :|:|:...||.:..|.:||.:|:|||:....|.|..:...|.:.:.|:..
Mouse  1300 FNNYQVRYRPELDL-VLKGITCNIKSTEKVGVVGRTGAGKSSLTNCLFRILESAGGQIIIDGIDI 1363

  Fly  1126 TEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNIHNFISALPQG- 1189
            ....|..||.:|.::.|:|:||...:..|:...|.:.|    :||..|.:.:::.:|::.|..| 
Mouse  1364 ASIGLHDLRGRLTIIPQDPILFSGNLRMNLDPFNKYSD----EEIWRALELAHLKSFVAGLQLGL 1424

  Fly  1190 -YDTRLGKTSQLSGGQKQRIAIARALVRNPKILILDEATSALDLESEKVVQQALDEARSGRTCLT 1253
             ::...| ...||.||:|.:.:.||::|..|||:|||||:|:|||::.::|..:....|..|.:|
Mouse  1425 LHEVTEG-GDNLSIGQRQLLCLGRAVLRKSKILVLDEATAAVDLETDSLIQTTIRNEFSQCTVIT 1488

  Fly  1254 IAHRLTTVRNADLICVLKRGVVVEHGTHDELMALNKIYANL---YLMQQVSG 1302
            |||||.|:.::|.|.||..|.:||:|:.:||:      :|:   |||.:.:|
Mouse  1489 IAHRLHTIMDSDKIMVLDSGKIVEYGSPEELL------SNMGPFYLMAKEAG 1534

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mdr49NP_523724.2 MdlB 34..640 CDD:224055 125/534 (23%)
ABC_membrane 116..352 CDD:279056 39/213 (18%)
ABC_MTABC3_MDL1_MDL2 402..636 CDD:213216 71/241 (29%)
MdlB 735..1299 CDD:224055 138/613 (23%)
ABC_membrane 739..998 CDD:279056 49/297 (16%)
ABC_MTABC3_MDL1_MDL2 1059..1298 CDD:213216 79/243 (33%)
Abcc2NP_038834.2 MRP_assoc_pro 10..1535 CDD:188098 291/1287 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 260..285
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 903..927 7/23 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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