Protein Alignment Mdr49 and LOC100496268

DIOPT Version :10

• Sequence 1: NP_523724.2
• Gene: Mdr49 / 36428
• FlyBaseID: FBgn0004512
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: XP_004921510.2
• Gene: LOC100496268 / 100496268
• XenbaseID: XB-GENE-29083099
• Length: 1284
• Species: Xenopus tropicalis
• Alignment Length: 1330
• Identity: 551/1330 - (41%)
• Similarity: 803/1330 - (60%)
• Gaps: 121/1330 - (9%)

  Fly     3 KKEESRLPQAGDFQLKEGSVVDATRKYSYFDLFRYSTRCERFLLVVSLLVATAASAFIPYFMIIY 67
            |||::..|..                ...|.:||||:..:|.|::...:.:.:..|.:|..||::
 Frog    38 KKEKTEKPPT----------------VGVFTMFRYSSTSDRILMLFGTIASISHGAALPLMMIVF 86

  Fly    68 GEFTSLLVDRTVGVG-TSSPAFALPMFGGGQQLTNASK--EENNQAIIDDATAFGIGSLVGSVAM 129
            |:.|    |..|.|| ..|..|:|      :.|.|||:  :|.........:..|.|.|:.:...
 Frog    87 GDMT----DSFVNVGQVGSGNFSL------EALINASRNLQEQMTTYAYYYSGLGFGVLLFAYVQ 141

  Fly   130 FLLITLAIDLANRIALNQIDRIRKLFLEAMLRQDIAWYDTSSGSNFASKMTEDLDKLKEGIGEKI 194
            ....||:       |..||.|||..|..|:|||:|.|:|.:......:::|:|:.|:.||||:||
 Frog   142 ISFWTLS-------AGKQIKRIRSNFFHAVLRQEIGWFDVNDAGELNTRLTDDVSKINEGIGDKI 199

  Fly   195 VIVVFLIMTFVIGIVSAFVYGWKLTLVVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVE 259
            .:::..:.|||.|.:..||.|||||||:|:..|.:..:.::.|::..:...||||:|:.|..|.|
 Frog   200 AMLLQSLTTFVTGFIIGFVKGWKLTLVILAISPVMGFSAAIWAKVLSAFTNKELKAYAKAGAVAE 264

  Fly   260 EVFSGIRTVFAFSGQEKEKERFGKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMALAIWYGVTL 324
            ||.|.|||||||.||:||.:|:.|.|..|:..|.||.:.:.:....::|:||...|||.|||.||
 Frog   265 EVLSSIRTVFAFGGQDKEIKRYEKNLEEAKRIGIKKAITANVSIGFAFLMIYAAYALAFWYGTTL 329

  Fly   325 ILDERDLPDRVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMD 389
            |::..      ||...::.|.||||:||..:|..||:|||.|.|..|..|:|||||...::|...
 Frog   330 IINGG------YTIGSVLTVFFAVIIGAFAVGQTSPNVEAFANARGAAYTIFNIIDNQPKIDSFS 388

  Fly   390 EKGNRPENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRFY 454
            ::|.:|:...|.|.|:.::|.||:|.|:::||||.:::..|:|||.||:|||||||.:||:||||
 Frog   389 KEGLKPDKIKGDIEFKNVKFTYPSRTDIQVLKGLNLNIPSGKTVALVGSSGCGKSTTVQLIQRFY 453

  Fly   455 DPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQADIEKAARAANC 519
            |||.|.:.|||:|:|:||:.:||..||||.|||:||.|||.:||||||...|..:||:|.:.||.
 Frog   454 DPEEGVITLDGQDIRSLNIRYLREIIGVVSQEPILFDTTIADNIRYGREDVTMEEIERATKEANA 518

  Fly   520 HDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSALE 584
            ::||.:||..::|.|||:|.|:||||||||||||||||.|::|||||||||||..||..||:||:
 Frog   519 YNFIMKLPDKFETLVGERGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESESVVQAALD 583

  Fly   585 LASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELMERRGLYCELVSITQRKEATEADE 649
            .|.:|.||:|||||||||.|||.|....:||:.|||.|:|||::.|:|..||::...:.:.:.:|
 Frog   584 KAREGRTTIVVAHRLSTIRNADVIAGFDNGVIVEQGGHKELMDKGGVYFNLVTLQTVETSKDTEE 648

  Fly   650 GAVAGRPLQKSQNLSDE------------------------ETDDDEEDEEEDEEPELQTSGSSR 690
            ..        ..|||::                        |||:.||.:||.
 Frog   649 NL--------ELNLSEKIPLSHTSSNLVRRKSSRHTIKKVTETDNKEEVDEEG------------ 693

  Fly   691 DSGFRASTRRKRRSQRRKKKKDKEVVSKVSFTQLMKLNSPEWRFIVVGGIASVMHGATFPLWGLF 755
                             |||:|..  ..|||.::|:||..||.:.|||.|.::::|||.|.:.:.
 Frog   694 -----------------KKKEDGP--PPVSFLKVMRLNKTEWPYFVVGIICAMINGATQPAFAII 739

  Fly   756 FGDFFGILSDGDDDVVRAEVLKISMIFVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTII 820
            |....|:.: |....:||:....|::|:.:|.::.:...||.:.|..||..:|.|||..:|.:::
 Frog   740 FSKIIGVFA-GPASEMRAKSTMYSLLFLALGGISFITFFLQGFTFGKAGEILTKRLRLWSFKSML 803

  Fly   821 GQDIAYFDDERNSVGALCSRLASDCSNVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTL 885
            .|:|.:|||.:||.|||.:|||:|.|.||||||:|:..:.|.:|.|...:::.|::.|:.|||.|
 Frog   804 RQEIGWFDDTKNSTGALTTRLATDASQVQGATGSRLALLAQNIANLGTAVIISFIYGWRLTLLIL 868

  Fly   886 VTLPLVCLSVYLEGRFIMKSAQKAKASIEEASQVAVEAITNIRTVNGLCLERQVLDQYVQQIDRV 950
            ..:|::..|..::.:.....|:|.|..:|:|.:::.:|:.|||||..|..||:....|.:.::..
 Frog   869 AIVPIIAASALVQLKMFAGHAKKDKKELEKAGKISTDAVLNIRTVVSLTRERKFEAMYEKNLEGP 933

  Fly   951 DIACRRKVRFRGLVFALGQAAPFLAYGISMYYGGILVAEERMNYEDIIKVAEALIFGSWMLGQAL 1015
            .....:|....||.:||.||..:.||.....:|..||||..|..:|:..|..|::||:..|||..
 Frog   934 YRNSIKKAHLHGLTYALSQAIMYFAYAGCFRFGAYLVAELLMTPDDVFLVFSAIVFGAMALGQTS 998

  Fly  1016 AYAPNVNDAILSAGRLMDLFKRT------STQPNPPQSPYNTVEKSEGDIVYENVGFEYPTRKGT 1074
            ::||:...|::||..:..|.:|.      |.:...||:       ..|::.::.|.|.||||...
 Frog   999 SFAPDYTKAMISAAHIFSLLERVPLIDSYSKEGEKPQN-------CGGNVQFQGVQFNYPTRPDI 1056

  Fly  1075 PILQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFPLDTLRSKLGL 1139
            .:||||::::|:..|:||||.||.||||.|.||.|:|||..|.|.:.|....:..:..:|:::|:
 Frog  1057 TVLQGLDISVKQGETLALVGSSGCGKSTTVSLLERFYDPFGGEVLVDGHSVRDLNIQWVRAQMGI 1121

  Fly  1140 VSQEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRLG-KTSQLSGG 1203
            |||||:|||.:|.||||||:|.| :|:..||..|||::|||:||..|...|:||:| |.:|:|||
 Frog  1122 VSQEPILFDCSIGENIAYGDNSR-EVTQAEIETAAKEANIHSFIDTLTDKYNTRVGDKGTQMSGG 1185

  Fly  1204 QKQRIAIARALVRNPKILILDEATSALDLESEKVVQQALDEARSGRTCLTIAHRLTTVRNADLIC 1268
            |||||||||||||.||||:|||||||||.|||||||:|||:||:||||:.|||||:|::|||.|.
 Frog  1186 QKQRIAIARALVRKPKILLLDEATSALDTESEKVVQEALDKARTGRTCIVIAHRLSTIQNADKIA 1250

  Fly  1269 VLKRGVVVEHGTHDELMALNKIYANLYLMQ 1298
            |::.|.|||.|||.:|:.|..:|..|..:|
 Frog  1251 VIQNGKVVEQGTHQQLLQLKGVYYTLVTIQ 1280

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	44..643	CDD:440747	273/601 (45%)
		MdlB	720..1299	CDD:440747	252/586 (43%)
LOC100496268	XP_004921510.2	PTZ00265	1..1279	CDD:240339	550/1327 (41%)