Protein Alignment Mdr49 and abcb11.2

DIOPT Version :9

• Sequence 1: NP_523724.2
• Gene: Mdr49 / 36428
• FlyBaseID: FBgn0004512
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: XP_004917764.1
• Gene: abcb11.2 / 100489579
• XenbaseID: XB-GENE-988819
• Length: 1349
• Species: Xenopus tropicalis
• Alignment Length: 1359
• Identity: 540/1359 - (39%)
• Similarity: 792/1359 - (58%)
• Gaps: 125/1359 - (9%)

  Fly     3 KKEESRLPQAGDFQLKEGSVVDATRKYSYFDLFRYSTRCERFLLVVSLLVATAASAFIPYFMIIY 67
            ||:||:       :..|.|:     :..:|.|||::|..|..:::...|.|....|..|..::::
 Frog    41 KKDESK-------KKPEDSI-----RVGFFQLFRFATCSETTMMLFGSLAAIIHGAAQPCMLLVF 93

  Fly    68 GEFTSLLVDRTVGVGTSSPAFALPMFGGGQQLTNASKEENNQAII---------DDATAFGIGSL 123
            |    |::|..:       .:.:.|    |:|.:.:|...|..|.         .|...|..|.|
 Frog    94 G----LMIDTFI-------EYDIEM----QELRDPNKTCTNNTITWTNGSLVPDKDNKTFSCGML 143

  Fly   124 ---------------VGSVAMFLLITLAIDLANRIALNQIDRIRKLFLEAMLRQDIAWYDTSSGS 173
                           :| .::.:|..:.|......|..||.|||||:...::|.:|.|:|.:|..
 Frog   144 DIELEMTNFASYYAGIG-CSVLILGYMQICFWVTAAARQIQRIRKLYFRKVMRMEIGWFDCTSVG 207

  Fly   174 NFASKMTEDLDKLKEGIGEKIVIVVFLIMTFVIGIVSAFVYGWKLTLVVLSCVPFIIAATSVVAR 238
            ...::|::|::|:.:.|.:::.|.:....||:.|.:..||.||||||::::..|.|....:::|.
 Frog   208 ELNTRMSDDINKINDAIADQVGIFIQRFTTFLSGFLLGFVNGWKLTLIIIAVSPLIGVGAALMAL 272

  Fly   239 LQGSLAEKELKSYSDAANVVEEVFSGIRTVFAFSGQEKEKERFGKLLIPAENTGRKKGLYSGMGN 303
            ....|..:||.:|:.|..|.:||.||||||.||.|:.||.:|:.:.|:.|:..|.:||:..|...
 Frog   273 AVAKLTGRELLAYAKAGAVADEVLSGIRTVAAFGGETKEVDRYDRNLVYAQRWGIRKGIIMGFFT 337

  Fly   304 ALSWLIIYLCMALAIWYGVTLILDERDLPDRVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVA 368
            ...|.||:||.|||.|||..|:|:|.:     |:|..|:.|...|::||.|||.|||.::|.|..
 Frog   338 GYMWFIIFLCYALAFWYGSKLVLEEEE-----YSPGNLLQVFLGVLVGALNLGQASPCLQAFASG 397

  Fly   369 TAAGQTLFNIIDRPSQVDPMDEKGNRPENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTV 433
            ..|...:|..||...::|.|.|:|.:.:...|.|.|..|.|.||:||:|:||..:.:.:..|:|.
 Frog   398 RGAATNIFETIDNEPKIDCMSEEGYKLDKVKGEIEFHNISFHYPSRPEVKILDKINMVIKSGETT 462

  Fly   434 AFVGASGCGKSTLIQLMQRFYDPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENI 498
            ||||.||.||||.:||:||||||:.|.|.|||.|:|:||:.||||.||:|.||||||||||.|||
 Frog   463 AFVGPSGAGKSTTVQLIQRFYDPDVGMVTLDGHDIRSLNIQWLRSLIGIVEQEPVLFATTIAENI 527

  Fly   499 RYGRPSATQADIEKAARAANCHDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLL 563
            |||:.:||..:|..||:.||.::||..||:.:||.|||.|.|:||||||||||||||||.|::||
 Frog   528 RYGKENATMEEIITAAKEANAYNFIMDLPQKFDTLVGEGGGQMSGGQKQRIAIARALVRNPRILL 592

  Fly   564 LDEATSALDPTSEKRVQSALELASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELMER 628
            ||.||||||..||..||.||:....|.||:.:|||||||.|||.||..:.|...|:|||:||:||
 Frog   593 LDMATSALDNESEAIVQEALDKVRFGRTTISIAHRLSTIKNADVIVGFEHGRAVEKGTHDELLER 657

  Fly   629 RGLYCELVSITQRKEATEADEGAVAGRPLQKSQNLSDEETDDDEEDEEEDEEPELQT----SGSS 689
            :|:|..||::        ..:|..|...::|.           ::..:|.|||:|:|    ...|
 Frog   658 KGVYFTLVTL--------QSQGDKALHNMEKK-----------DKSNKEFEEPKLETLQPLKRGS 703

  Fly   690 RDSGFRASTRRKRRSQ-------------------------------RRKKKKDKEVVSKVS--- 720
            ..:..|||.|::.|||                               .....|.:|:|..:.
 Frog   704 YQASLRASIRQRSRSQLSNLVPDTPLLVVGADASDPIQHSTHYDDESDNNMIKTEEIVEDIEPAP 768

  Fly   721 FTQLMKLNSPEWRFIVVGGIASVMHGATFPLWGLFFGDFFGILSDGDDDVVRAEVLKISMIFVGI 785
            ..:::|.|:|||.:::.|.|.:.::||..||:.|.|....||.|..|::..|.::..|.::||.|
 Frog   769 VARILKYNAPEWPYMLFGSIGAAINGAVSPLYALLFSQILGIFSLPDEEEQRDQINGICVLFVLI 833

  Fly   786 GLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERNSVGALCSRLASDCSNVQG 850
            |:::.|...||.|.|..:|..:|.||||..|.:::||::.:|||.|||.|||.:|||:|.|.|||
 Frog   834 GVVSFLTQFLQGYTFAKSGELLTRRLRKLGFRSMLGQEVGWFDDPRNSPGALTTRLATDASQVQG 898

  Fly   851 ATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMKSAQKAKASIEE 915
            |||:::|.::.|::.:.|.:::.|.|||:.||:.:..||.:.:|..|:.:.:...|.:.|.::|.
 Frog   899 ATGSQIGMIVNAISNIGVALIIAFYFSWKLTLVIMCFLPFLAVSGALQAKMLTGFANQDKHAMES 963

  Fly   916 ASQVAVEAITNIRTVNGLCLERQVLDQYVQQIDRVDIACRRKVRFRGLVFALGQAAPFLAYGISM 980
            |.:::.||:.||||:.|:..|:..:|.|.:|::....:..:|....||.|...|...|:|..:|.
 Frog   964 AGRISSEALGNIRTIAGIAKEKTFVDMYEEQLEAPYRSAIKKANVYGLCFGFAQCIVFIANTVSY 1028

  Fly   981 YYGGILVAEERMNYEDIIKVAEALIFGSWMLGQALAYAPNVNDAILSAGRLMDLFKRTSTQPNPP 1045
            .|||.||.:|.::|..:.:|..:::.....||:|.:|.|:...|.:||.|...|..|.     |.
 Frog  1029 RYGGYLVDKEGLHYSFVFRVISSIVTSGTALGRASSYTPDYAKAKISAARFFKLVDRI-----PK 1088

  Fly  1046 QSPYNTVEKS----EGDIVYENVGFEYPTRKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQL 1106
            .|.|....:.    :|.|.:::..|.||||....:|.||::::|...|:|.||.||.||||.|||
 Frog  1089 ISVYTDHGERWPDFKGSIDFQDCKFTYPTRPDIQVLNGLDVSVKPGQTLAFVGSSGCGKSTSVQL 1153

  Fly  1107 LLRYYDPVSGSVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVSMQEII 1171
            |.|:|||..|.|.:.|..|....:..||||:|:|||||||||.:|.|||.||:| ..::|..:||
 Frog  1154 LERFYDPDKGKVLIDGHNSKNVNVAFLRSKIGIVSQEPVLFDCSIIENIRYGDN-NQELSKDKII 1217

  Fly  1172 EAAKKSNIHNFISALPQGYDTRLG-KTSQLSGGQKQRIAIARALVRNPKILILDEATSALDLESE 1235
            ||:||:.:|:|:..||..|||.:| ..||||.|||||||||||:||:||||:|||||||||.|||
 Frog  1218 EASKKAQLHDFVMGLPDKYDTNVGAHGSQLSRGQKQRIAIARAIVRDPKILLLDEATSALDTESE 1282

  Fly  1236 KVVQQALDEARSGRTCLTIAHRLTTVRNADLICVLKRGVVVEHGTHDELMALNKIYANL 1294
            |.||.|||.||.||||:.|||||:|::|:|:|.|:.||:|:|.|.|:|||.....|..|
 Frog  1283 KTVQAALDRAREGRTCIVIAHRLSTIQNSDIIAVMSRGIVIEKGNHEELMEKKGAYYKL 1341

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	34..640	CDD:224055	263/629 (42%)
		ABC_membrane	116..352	CDD:279056	83/250 (33%)
		ABC_MTABC3_MDL1_MDL2	402..636	CDD:213216	140/233 (60%)
		MdlB	735..1299	CDD:224055	245/565 (43%)
		ABC_membrane	739..998	CDD:279056	94/258 (36%)
		ABC_MTABC3_MDL1_MDL2	1059..1298	CDD:213216	134/237 (57%)
abcb11.2	XP_004917764.1	PTZ00265	159..1340	CDD:240339	510/1211 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	193	1.000	Domainoid score	I3130
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010