Protein Alignment Mdr49 and tap2

DIOPT Version :9

• Sequence 1: NP_523724.2
• Gene: Mdr49 / 36428
• FlyBaseID: FBgn0004512
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: XP_002942649.3
• Gene: tap2 / 100489020
• XenbaseID: XB-GENE-481680
• Length: 728
• Species: Xenopus tropicalis
• Alignment Length: 645
• Identity: 185/645 - (28%)
• Similarity: 313/645 - (48%)
• Gaps: 111/645 - (17%)

  Fly    19 EGSVVDATR-KYSYFDLFRYS-----TRCERFLLVVSLLVATAASAFIPYFMIIYGEFTSLLVDR 77
            ||......| :.::..|.:||     ..|..|   |.|.:|.....||||:|   |....:|
 Frog   141 EGEANSKKRERENFIRLLKYSIPDWLPLCGAF---VFLTLALIGEMFIPYYM---GRVIDIL--- 196

  Fly    78 TVGVGTSSPAFALPMFGGGQQLTNASKEENNQAIIDDATAFGIGSLV-----GSVAMFLLITLAI 137
                                 .||.::.|..:| :.....|.|.|.:     |.:.||.|..|.
 Frog   197 ---------------------STNYNEREFLRA-MSFMAMFSITSSIFAGSRGGLFMFSLARLT- 238

  Fly   138 DLANRIALNQIDRIRKLFLEAMLRQDIAWYDTSSGSNFASKMTEDLDKLKEGIGEKIVIVVFLIM 202
                       .|:|.|...::::|:||:::.:...:..|::|.|..::...|...:.|.:.:::
 Frog   239 -----------QRLRLLLFRSVIKQEIAFFEATKSGDITSRLTNDTARVSRSIAANVNITLRMLV 292

  Fly   203 TFVIGIVS-AFVYGWKLTLV--VLSCVPFIIAAT------SVVARLQGSLAEKELKSYSDAANVV 258
            . .:|:.| .|...|:|||:  :.|.:.:||...      .:|.|:|.|:|.        ::.:.
 Frog   293 K-CVGVYSFMFSLSWQLTLLTFISSPLTWIIQKVYNYYHQDLVKRVQDSIAR--------SSELA 348

  Fly   259 EEVFSGIRTVFAFSGQEKEKERFGKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMALAIWYG-- 321
            :|:...:|.|::|:.:|:|.:|:...|........::...:.:...::.|:........::||
 Frog   349 KEIIESVRNVYSFAAEEEEAKRYENSLQETHVLQTRRDFVTALYLLVTRLVNLGTQVTMLYYGQI 413

  Fly   322 ------------VTLILDERDLPDRVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQT 374
                        |:.||.:.:....:.|   ||.:|                 ..|..|..|.:.
 Frog   414 LIRSGFISSGKMVSFILYQMESDSYIRT---LVHML-----------------SEITHAAGAAEK 458

  Fly   375 LFNIIDRPSQVDPMDEKGNR-PENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGA 438
            :|..:||..||   ...|.. |....|...|..:.|.||:||::..|:.::..:.||...|.||.
 Frog   459 VFQYLDREPQV---SASGCLCPGTLQGRFEFSNVTFSYPSRPEILALQNVSFTLPPGSVTALVGP 520

  Fly   439 SGCGKSTLIQLMQRFYDPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRP 503
            ||.||:|.:.|::|||:|:.|::.|||:.|:.....:|.|::.:|.|||||||.::.|||.||..
 Frog   521 SGGGKTTCVSLLERFYEPQGGNILLDGKPLKEYKHEYLHSKVALVAQEPVLFAGSVRENISYGLY 585

  Fly   504 SATQADIEKAARAANCHDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEAT 568
            :..:..::.|||.|...|||..:.|.|||.||..|||:|.|||||:|:||||.|:|::|:||||:
 Frog   586 NIPEEKLKAAARKAKAEDFIEGMEKAYDTDVGNSGAQLSAGQKQRVALARALARKPKLLILDEAS 650

  Fly   569 SALDPTSEKRVQSALELASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELMER 628
            |.||..:|..:|.:|: :.:..:.|::||||.|:..||:|:.|:.|.:.||||||:|:::
 Frog   651 SCLDAETEHEIQKSLQ-SIEDLSLLIIAHRLRTVQKADQILVLEAGNLVEQGTHEKLVQK 709

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	34..640	CDD:224055	182/629 (29%)
		ABC_membrane	116..352	CDD:279056	52/263 (20%)
		ABC_MTABC3_MDL1_MDL2	402..636	CDD:213216	100/227 (44%)
		MdlB	735..1299	CDD:224055
		ABC_membrane	739..998	CDD:279056
		ABC_MTABC3_MDL1_MDL2	1059..1298	CDD:213216
tap2	XP_002942649.3	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910