DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mdr49 and tap1

DIOPT Version :9

Sequence 1:	NP_523724.2	Gene:	Mdr49 / 36428	FlyBaseID:	FBgn0004512	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	XP_002665053.1	Gene:	tap1 / 100333043	ZFINID:	ZDB-GENE-050517-43	Length:	731	Species:	Danio rerio

Alignment Length:	648	Identity:	212/648 - (32%)
Similarity:	343/648 - (52%)	Gaps:	77/648 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 FLLVVSLLV---------------------ATAASAFIPYFMIIYGEFTSLLVDRTVGVGTSSPA 87
            |:|.:|||:                     ..:....:.|.....|.|.::.....:   :|...
Zfish   115 FVLGLSLLIWKRHVPTILLTAKKERTEKKGKASLQRLLGYMKPFSGRFAAVFFFVVI---SSLGE 176

  Fly    88 FALPMFGGGQQLTN-ASKEENNQAIIDDATAFGIGSLVGSVAMFLLITLAIDLANRIALNQI-DR 150
            .|:|.:.|  ::|: ...|:..:|.....|...:.:::.:|..|:     .||...|.:::| ..
Zfish   177 MAIPHYTG--KMTDWIMNEDEPEAFNHAITVMTLMTIMSAVCEFV-----CDLIYNITMSRIHTS 234

  Fly   151 IRKLFLEAMLRQDIAWYDTSSGSNFASKMTEDLDKLKEGIGEKIVIVVFLIMTFVIGIVSAFVYG 215
            |:.|..:|:|:||||::|.::..:..|::|.|.:.:.|.:.||:.::::..|..:      |::|
Zfish   235 IQGLVFQAVLKQDIAFFDKATTGDIVSRITTDTNTMSESLSEKLSLLMWYFMRVI------FLFG 293

  Fly   216 WKLTLVVLSC------VPFIIAATSVVARLQGSLAEKELKSYSDAANVVEEVFSGIRTVFAFSGQ 274
            ..|.|....|      :|.|.....:..|....|:.:...|.:.|..|..|.||.::||.:|:.:
Zfish   294 SMLMLSTRLCCFTLLGLPVIWIIPEIFGRFYQKLSAQVQDSLAKANEVATETFSSMKTVRSFANE 358

  Fly   275 EKEKERFGKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMALAI---WYGVTLI----LDERDLP 332
            :.|.||:.|.|   |:|.....:.:......:|......:||.:   :||..|:    :...||.
Zfish   359 DGETERYRKCL---EDTFALNKVEAAAYAVSTWTNSMSSLALKVSILYYGGRLVTGSDVSSGDLV 420

  Fly   333 DRV-----YTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMDEKG 392
            ..|     :|.||.|::.:            .|||:.   |..|.:.:|..:||...|.|  :..
Zfish   421 SFVLYELQFTSAVEVLMSY------------WPHVKK---AVGASEKIFEYVDRKPDVPP--DGS 468

  Fly   393 NRPENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRFYDPE 457
            ..|:...||::|..:.|.||.|||.::||.:::::..|:..|.||.||.||:|::.|::|||.|:
Zfish   469 LAPKTLKGHVQFRNVTFAYPKRPDTDVLKNVSLELKAGKITALVGPSGSGKTTVVSLLERFYQPQ 533

  Fly   458 AGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQADIEKAARAANCHDF 522
            .|.:.||.:.|.:....:|..:|.||.|||||||.::.|||:||:.:||..:|..|||.||.|||
Zfish   534 NGEILLDQKPLLSYKDQYLHEKISVVSQEPVLFARSVRENIKYGKENATNEEIYAAARLANAHDF 598

  Fly   523 ITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSALELAS 587
            |:.|||||||..||||.|:||||||||||||||:::||:|:||:|||:||..||.||.|||:...
Zfish   599 ISSLPKGYDTDAGEKGGQVSGGQKQRIAIARALIQKPQILVLDDATSSLDTESEHRVYSALKKEL 663

  Fly   588 QGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELMERRGLYCELVSITQRKEATEADEG 650
            |..|.|:::||||.:.|||.|:||::|.:.|:|.|::|::::|.|.|.|..........||.|
Zfish   664 QSCTVLLISHRLSGVENADHILFLREGELVEEGNHQQLLDKQGFYAEFVKQQNTAIHRNADNG 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	34..640	CDD:224055	209/636 (33%)
		ABC_membrane	116..352	CDD:279056	61/254 (24%)
		ABC_MTABC3_MDL1_MDL2	402..636	CDD:213216	119/233 (51%)
		MdlB	735..1299	CDD:224055
		ABC_membrane	739..998	CDD:279056
		ABC_MTABC3_MDL1_MDL2	1059..1298	CDD:213216
tap1	XP_002665053.1	3a01208	42..712	CDD:273363	208/632 (33%)
		ABC_membrane	166..433	CDD:279056	65/285 (23%)
		P-loop_NTPase	467..692	CDD:304359	115/224 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910