DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mdr49 and abcc8b

DIOPT Version :9

Sequence 1:NP_523724.2 Gene:Mdr49 / 36428 FlyBaseID:FBgn0004512 Length:1302 Species:Drosophila melanogaster
Sequence 2:XP_021323602.1 Gene:abcc8b / 100329706 ZFINID:ZDB-GENE-120215-45 Length:1607 Species:Danio rerio


Alignment Length:1344 Identity:310/1344 - (23%)
Similarity:551/1344 - (40%) Gaps:293/1344 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   118 FGIGSLVGSVAMFLLITL---------------AIDLANRIALNQIDRIRKLFLEAMLRQDIAWY 167
            |...:.|.:|.:||.:.|               .|:|...:.....::|.:|....|...|:.  
Zfish   366 FFANAYVLAVLLFLALLLQRTFLQASYYVAIENGINLRGAVQTKIYNKIMRLCTSNMSMGDMT-- 428

  Fly   168 DTSSGSNFASKMTEDL-------DKLKEGIGEKIVIVVFLIMTFVIGIVSAFVYGWKLTLVVLSC 225
             |:...|..::.|..|       ..| ..:..:|||.| |::.:::| .||.:....:|  ||:.
Zfish   429 -TAQICNLVARDTNQLMWFFFLCPNL-WAMPVQIVIGV-LLLYYLLG-ASALIGATVIT--VLAP 487

  Fly   226 VPFIIAATSVVARLQGSLAEKELKSY-SDAANVVEEVFSGIRT--------VFAFSGQEKEKERF 281
            :.:.:|     .||  |.|:|....| |:......|:..||:.        :|..|.:|..::..
Zfish   488 LQYFVA-----TRL--SRAQKSTLEYTSERLKKTNELLRGIKLLKLYAWEHIFRSSVEETRRQEL 545

  Fly   282 GKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMALAIWYGVTLILDERDL---PDRVYTPAVLV- 342
            ..|        |...||:.       |.|::..|:.|...:|:.:....|   .|...:|||.. 
Zfish   546 TSL--------RTFALYTS-------LSIFMNAAIPIAAVLTIFVVHVHLQSSSDFALSPAVAFG 595

  Fly   343 -IVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMDEKGNRPENTAGHIR--- 403
             :.||.:::  ..|...|..:.:...|..:.|.|...:.........|.....|.|..|:|:   
Zfish   596 SLSLFHILV--TPLFLLSSVLHSTVKALVSVQKLSEFLSSAEIETDQDPIAQTPANNNGNIKSVY 658

  Fly   404 -----FEGIRFRYPARPDV-----------------------EILKG----------LT-VDV-L 428
                 .:.:..:..|:.||                       :|:.|          || :|: :
Zfish   659 ALQLQAKLVNRKNKAKQDVNRNFEQQDQELRASAQHEDNICIKIVNGYFSWTQGCPTLTNIDIKV 723

  Fly   429 P-GQTVAFVGASGCGKSTLIQL----MQRFYDPEAGSV-----------------KLDGRDLRTL 471
            | ||....||..|.|||:|:..    ||:.    :||:                 .:.||...| 
Zfish   724 PFGQLTMIVGQVGSGKSSLLLAALGEMQKI----SGSITWNSLPRSDSDENIRAHDMSGRQSFT- 783

  Fly   472 NVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQADIEK---AARAANCHDFITRLPKGYDTQ 533
                .|..:....|.|.|...|:.|||.:.    |..::::   ..........|..||:|..|.
Zfish   784 ----RRGSVAYASQRPWLLNATVEENILFD----TAPNVKRYKDVIEVCQLGPDIDTLPQGDQTV 840

  Fly   534 VGEK----GAQISGGQKQRIAIARALVRQPQVLLLDEATSALD-PTSEKRVQSAL--ELASQGPT 591
            :||:    |..:||||:|||::||||.:|..|:.||:..|||| ..|:..:...:  .|..:..:
Zfish   841 IGERVRHLGIILSGGQRQRISVARALYQQTNVVFLDDPFSALDIHLSDHLMHEGILKFLRQEKRS 905

  Fly   592 TLVVAHRLSTITNADKIVFLKDGVVAEQGT-------HEELMERRGLYCELVSITQRKEATEADE 649
            .::|.|:|..:.:||.|:.::||.|..|||       ..||.|:   :..|::...::.:||   
Zfish   906 VVLVTHKLQYLPHADWIIAMRDGTVQTQGTLKDIQCAEPELFEQ---WRTLMNRQDKENSTE--- 964

  Fly   650 GAVAGRPLQKSQNLSDEETDDDEEDEEED-EEPELQTSGSSRDSGFRASTRRKRRSQRRKKKKDK 713
              :..:..:::...|.:....|:|||..| ...|::.|.:|.|.....:..|.|.:         
Zfish   965 --LKRKSFRRAMMYSRDTVATDDEDEVADVAVSEVKDSSTSTDEDSLGAELRHRTT--------- 1018

  Fly   714 EVVSKVSFTQLMKLNS----PEWRFIVVGGIA--SVMHGATFPLWGLFFGDFFGILSDGDDDVVR 772
              :...||...:|...    |   .::|..:|  |:|....|  |          |:....||:.
Zfish  1019 --IPWSSFATYLKAAGLFLLP---LLIVSQLAKHSLMVAIDF--W----------LAHWTSDVIA 1066

  Fly   773 AE--------------------VLKISMIFVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFG 817
            |:                    .|::..:...:|::..|...|..   ...|:::...|......
Zfish  1067 AQSESAERNCTFTKDCVFSHSWYLQVFCLLCALGIVLCLVTSLAV---EWTGLRVAKELHCSLLR 1128

  Fly   818 TIIGQDIAYFDDERNSVGALCSRLASDCSNVQGATGARVGTMLQAV--ATLVVGMVVGFVFSWQQ 880
            .|:...:..|  |...:|.:.:|.::|.:.:.    ..:...::.:  :||:....|| |.|:..
Zfish  1129 IIVLAPMRLF--ETTPLGNILNRFSTDTNTID----QHIPVTMECLSRSTLLCVSAVG-VISYVT 1186

  Fly   881 TLLTLVTLPLVCLSVYLEGRFIMKSAQKAKASIEEASQV--------AVEAITNIRTVNGLCLER 937
            .:..:..|||.....:::..|  :.|.:....:|:::::        .:|.:|.||....   |:
Zfish  1187 PVFLIALLPLTVACYFIQKYF--RVASRDLQQLEDSTEMPLLSHYSQTIEGLTTIRAFRH---EQ 1246

  Fly   938 QVLDQYVQQIDRVDIACRRKVRFRGLVFALGQAAPFLAYGISMYYGGILVAEERMNYEDIIKVAE 1002
            :...:.::..|..:|:.          ..|..|..:|.  :.|.|.|.||    :....:..:..
Zfish  1247 RFKKKLLEHTDANNISS----------LFLTAANRWLE--VRMEYIGALV----VLIAAVASITN 1295

  Fly  1003 ALI--FGSWMLGQALAYAPNVNDAILSAGR-LMDL------FKRTS----TQP-------NPPQS 1047
            ||.  ..:.::|..|.||..|::.:....| |.|:      .||.|    |||       .|.|.
Zfish  1296 ALYRQLSAGLVGLGLTYALMVSNYLNWIVRNLADMEVQLGCVKRVSGLIHTQPESYDNIMTPAQV 1360

  Fly  1048 PYNTVEKSEGDIVYENVGFEYPTRKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYD 1112
            |...  ...|:|..:|:...|.:.. .|:|:.::..|:....|.:.|.:|||||:....|.|..|
Zfish  1361 PAGW--PKYGEIQIQNLSVRYDSSL-KPVLKHVSAHIRPGQKVGICGRTGSGKSSFSLALFRMVD 1422

  Fly  1113 PVSGSVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKS 1177
            ...|.:::.|:..::.||.|||||..::.|:|:||..||..|:.......|:: :.|.:|.|:..
Zfish  1423 TFEGQISIDGIDISKLPLQTLRSKFSIILQDPILFSGTIRFNLDPERKATDEM-LWEALEIAQLM 1486

  Fly  1178 NIHNFISALPQGYDTRLGKTSQ-LSGGQKQRIAIARALVRNPKILILDEATSALDLESEKVVQQA 1241
            .:   :.|||.|.|..:.:..: .|.||:|...:|||.||...|||:||||:::|:.:|.::|:.
Zfish  1487 PV---VKALPGGLDAVVTEGGENFSQGQRQLFCLARAFVRKSSILIMDEATASIDMATESILQKV 1548

  Fly  1242 LDEARSGRTCLTIAHRLTTVRNADLICVLKRGVVVEHGTHDELM 1285
            :..|.:.||.:|||||:.|:..:|::.|:|.|.::|:...|.|:
Zfish  1549 VMTAFADRTVVTIAHRVHTILGSDVVIVMKHGGIIEYDEPDVLL 1592

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mdr49NP_523724.2 MdlB 34..640 CDD:224055 147/639 (23%)
ABC_membrane 116..352 CDD:279056 58/269 (22%)
ABC_MTABC3_MDL1_MDL2 402..636 CDD:213216 79/315 (25%)
MdlB 735..1299 CDD:224055 145/604 (24%)
ABC_membrane 739..998 CDD:279056 48/290 (17%)
ABC_MTABC3_MDL1_MDL2 1059..1298 CDD:213216 76/228 (33%)
abcc8bXP_021323602.1 SunT 239..1600 CDD:331423 310/1344 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.000

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