Protein Alignment Mdr49 and abcb8

DIOPT Version :9

• Sequence 1: NP_523724.2
• Gene: Mdr49 / 36428
• FlyBaseID: FBgn0004512
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_001121515.1
• Gene: abcb8 / 100158634
• XenbaseID: XB-GENE-1010256
• Length: 688
• Species: Xenopus tropicalis
• Alignment Length: 648
• Identity: 209/648 - (32%)
• Similarity: 333/648 - (51%)
• Gaps: 78/648 - (12%)

  Fly    38 STRCERFLLVVSLLVATAASAFIPYFMIIYGEFTSLLVDRTVGVGTSSPAFALPMFGGGQQLTNA 102
            :.||:..|:...|:|...|.   |.....:.||..||..:.:.:.|:    .|..||.
 Frog    80 AARCQVELIAPPLIVPQGAR---PEPEFNWAEFWKLLRPQLIALLTA----VLLAFGA------- 130

  Fly   103 SKEENNQAIIDDATAFGIGSLVGSVAMF---------------------------LLITLAIDLA 140
                   |:::......:|.||..|:.:                           ||....|.|.
 Frog   131 -------ALLNIRIPLMLGELVNVVSRYTREHAGNYLQEVQGPALKLLCLYGAQGLLTCGYIVLL 188

  Fly   141 NRIALNQIDRIRKLFLEAMLRQDIAWYDTSSGSNFASKMTEDLDKLKEGIGEKIVIVVFLIMTFV 205
            :|:.......:||....::||||:|::|........:::|.|:.:.|... ::::......:|..
 Frog   189 SRVGERVAGSMRKSLFFSLLRQDVAFFDAEKTGLLVNRLTSDVQEFKSSF-KQVISQGLRSLTQT 252

  Fly   206 IG-IVSAFVYGWKLTLVVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEEVFSGIRTVF 269
            :| .:|.:....|||.::|..:|.::.:.:::......|:.:..:..:.|..:.:|....:|||.
 Frog   253 VGCFLSLYYISPKLTGLLLVVMPVLVGSGALIGSFLRKLSRRAQEQVARATGLADEALGNVRTVK 317

  Fly   270 AFSGQEKEKERFGKLLIPAE---NTGRKK------GLYSGMGNALSWLIIYLCMALAIWYGVTLI 325
            ||:.:.:|.|     |..||   ::|:.:      .::.|:.|     ::..|:.|...:....:
 Frog   318 AFAMESREME-----LYSAEVDKSSGQNEVLGVGIAVFQGLSN-----VVLNCIVLGTIFAGGSL 372

  Fly   326 LDERDLPDRVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMDE 390
            :..::|     :...|:..|.|.....:::...|.....:....:||..:|..:.....: |: .
 Frog   373 MSSKEL-----SAGELMSFLVASQTVQRSMANMSVLFGQVVRGLSAGGRVFEFMSLEPTI-PL-S 430

  Fly   391 KGNRPENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRFYD 455
            .|.:.....|.|.|:.:.|.||.||..|:|:...:.:..|:|||.||.||.||||:..|::||||
 Frog   431 GGFKLPVLRGEIHFKDVSFSYPTRPGHEVLRSFDLRIPHGKTVALVGQSGGGKSTVAALLERFYD 495

  Fly   456 PEAGSVKLDGRDLRTLNVGWLRSQ-IGVVGQEPVLFATTIGENIRYGRPSATQADIEKAARAANC 519
            |..|:|:|||.|:|.|:..|||.: ||.:.||||||.|||.||||:|||.||.|::.:||..||.
 Frog   496 PTEGAVQLDGVDIRILDPSWLRGEVIGFINQEPVLFGTTIIENIRFGRPDATDAEVHEAAIQANA 560

  Fly   520 HDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSALE 584
            ..||...|:||:|.:||:|..:|||||||:||||||::.|::|:|||||||||..||:.||.||:
 Frog   561 DSFIRSFPEGYNTMLGERGVTLSGGQKQRVAIARALLKDPKILILDEATSALDTESERAVQVALD 625

  Fly   585 LASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELMERRGLYCELVSITQRKEATEA 647
            .|..|.|.||:|||||||:.||.||.|..|.|||.|||::|:.|.|||.:|:. .|.:|:.||
 Frog   626 RARSGRTVLVIAHRLSTISEADFIVVLSKGQVAEFGTHQDLLRRGGLYADLIR-RQNQESQEA 687

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	34..640	CDD:224055	205/639 (32%)
		ABC_membrane	116..352	CDD:279056	50/272 (18%)
		ABC_MTABC3_MDL1_MDL2	402..636	CDD:213216	131/234 (56%)
		MdlB	735..1299	CDD:224055
		ABC_membrane	739..998	CDD:279056
		ABC_MTABC3_MDL1_MDL2	1059..1298	CDD:213216
abcb8	NP_001121515.1	ABC_6TM_ABCB8_like	123..417	CDD:350018	57/327 (17%)
		MsbA_rel	187..680	CDD:131259	182/511 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910