DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mdr49 and abcb10

DIOPT Version :9

Sequence 1:	NP_523724.2	Gene:	Mdr49 / 36428	FlyBaseID:	FBgn0004512	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	XP_001343218.3	Gene:	abcb10 / 100003744	ZFINID:	ZDB-GENE-040525-2	Length:	710	Species:	Danio rerio

Alignment Length:	678	Identity:	228/678 - (33%)
Similarity:	353/678 - (52%)	Gaps:	96/678 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   656 PLQKSQNLSDEETDDDEEDEEEDEEPELQTSG---------------SSRDSGFRASTRRKRRSQ 705
            |:.|.:|:|....              |:|.|               :|.||. :.|.....:..
Zfish    56 PVYKGRNISKLSC--------------LRTEGLFSPKHSRHIVALYSTSTDSN-QTSKSVVNQES 105

  Fly   706 RRKKKKDKEVVSKVSFTQLMKLNSPE-WR------FIVVGGIASVMHGATFPLWGLFFGDFFGIL 763
            ..|...|...|......:|::|..|: ||      |:|:.  ::|...|.|     |.|.....:
Zfish   106 SAKTTADSLPVPSEDVKKLLQLAHPQRWRLTAAVGFLVIS--STVTMSAPF-----FLGKVIDTI 163

  Fly   764 SDGDDDVVRAEVLKISMIFVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFD 828
            .....:...:.:..:.::..|:.|..|..|..:.|:...:|.::..:||:..|.:|:.|::.:||
Zfish   164 YTSPTEDFSSSLTSLCLMLTGVFLCGGAANAARVYLMQISGQQIVRKLRESLFSSILKQELGFFD 228

  Fly   829 DERNSVGALCSRLASDCSNV--------------QGATGARVGTMLQAVATLVVGMVVGFVFSWQ 879
            ..|  .|.|.:||::|.:.|              ....||.||.||....:|     ..||.
Zfish   229 KTR--TGELINRLSADTAIVGRCLTDNLSDGLRSLAQAGAGVGMMLYVSPSL-----AAFVL--- 283

  Fly   880 QTLLTLVTLPLVCLSVYLEGRFIMKSAQKAKASIEEASQVAVEAITNIRTVNGLCLERQVLDQYV 944
                 :|..|:.||:| :.|||:...:::.:.::.||:|:|.|.|:|:|||.....|...:.:|.
Zfish   284 -----MVVPPIACLAV-IFGRFLRSISRRTQDALAEATQLAEERISNLRTVRAFGKELTEVQKYS 342

  Fly   945 QQIDRV-DIACRRKVRFRGLVFALGQAAPFLAYGISMYYGGILVAEERMNYEDIIKVAEALIFGS 1008
            |::|.: ::|.:..|...|.....|.:...:...: :|.||:|:|.|.|.   :.:::..|::..
Zfish   343 QKVDHIFELAKKEAVVSAGFYGVTGLSGNVIILSV-LYKGGLLMASEAMT---VGQLSSFLMYAF 403

  Fly  1009 WMLGQALAYAPNVNDAI---LSAG-RLMDLFKRTSTQPNPPQSPYN-----TVEKSEGDIVYENV 1064
            | :|.::|...:....:   |.|| ||.:|..|      .|:.|.|     |.|..:|::.:.||
Zfish   404 W-VGISIAGFSSFYSELMKGLGAGTRLWELIDR------KPEFPLNEGLVLTSELLKGELEFRNV 461

  Fly  1065 GFEYPTRKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFP 1129
            .|.|||||.:||.|.|:|.:...:.:|:||.||||||:.|.||||.|||.||.|::.|....:..
Zfish   462 SFAYPTRKDSPIFQDLSLHVPAGSVLAVVGSSGSGKSSLVSLLLRLYDPDSGIVSVDGHDIRDLN 526

  Fly  1130 LDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRL 1194
            ...|||.:|.||||||||..:||||||||......|::::|..||:.:|.|:||...|:||||.:
Zfish   527 PYWLRSHIGTVSQEPVLFSCSIAENIAYGAPDPSQVTVEDIYRAAQIANAHDFIQEFPKGYDTVV 591

  Fly  1195 G-KTSQLSGGQKQRIAIARALVRNPKILILDEATSALDLESEKVVQQALDEARSGRTCLTIAHRL 1258
            | |...||||||||:||||||::|||||:|||||||||.|:|.:||:||:....|||.|.|||||
Zfish   592 GEKGVLLSGGQKQRVAIARALLKNPKILLLDEATSALDAENEFLVQEALERLMDGRTVLIIAHRL 656

  Fly  1259 TTVRNADLICVLKRGVVVEHGTHDELMA 1286
            :|:::||.:.||.:..|:|.|:|.:|:|
Zfish   657 STIQSADSVAVLDQHRVMEIGSHSQLLA 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	34..640	CDD:224055
		ABC_membrane	116..352	CDD:279056
		ABC_MTABC3_MDL1_MDL2	402..636	CDD:213216
		MdlB	735..1299	CDD:224055	208/577 (36%)
		ABC_membrane	739..998	CDD:279056	67/273 (25%)
		ABC_MTABC3_MDL1_MDL2	1059..1298	CDD:213216	123/229 (54%)
abcb10	XP_001343218.3	MsbA_rel	123..697	CDD:131259	214/596 (36%)
		ABC_membrane	141..402	CDD:279056	70/287 (24%)
		P-loop_NTPase	457..697	CDD:304359	123/228 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910