DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sans and Anks4b

DIOPT Version :9

Sequence 1:	NP_610829.1	Gene:	Sans / 36427	FlyBaseID:	FBgn0033785	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_082361.2	Gene:	Anks4b / 72074	MGIID:	1919324	Length:	423	Species:	Mus musculus

Alignment Length:	537	Identity:	156/537 - (29%)
Similarity:	234/537 - (43%)	Gaps:	138/537 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SDRFHKAAKDGLLDVLAAATRKDTNAKDSDSMTPVMWAAFEGRLDALRLLCGRGGDPDKCDQFGN 67
            |.|:|:||.|..|::|..||::|.|..|.|.|||.:.||:.|.|:||.::|.|||||||||.:||
Mouse     2 STRYHQAASDSYLELLKEATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDKCDIWGN 66

  Fly    68 TALHLASAKGHLHCVDFLVKFGVNIYALDIDKHSAKDLAAINGRDEILRYLDVAFTNFEATEKKK 132
            |.||.|::.||.||:.|||.||.||:|||.|..|..|.||...:.|.:..||.|.|.......|:
Mouse    67 TPLHYAASNGHTHCISFLVNFGANIFALDNDLKSPLDAAASREQKECVALLDKAATVQNTMNPKR 131

  Fly   133 SKALKELAEKNCEKRVREYMKRQNQQQQRQDPEYSDLSAPSGSSKTGNMLSTLKQKIWSSQGNLN 197
            ...|||.|.||..|:::|..:.|.:.|.:....||  ...||:..:.:  |||.:...|
Mouse   132 VTRLKEQALKNARKQMKECERLQERHQNKMARTYS--KEDSGTISSSH--STLSRSFLS------ 186

  Fly   198 KTPRDTPPPTKFSDLVGNGSSSSGGSTIASRAGTVQKRPSQLQKQHSSTCPHSKISSDTDGGFKV 262
                                     :|.|.|.|::.|......|      ..||.:.||     .
Mouse   187 -------------------------TTSAGRFGSLSKGIKDTFK------IKSKKNKDT-----T 215

  Fly   263 REVEPDGKRTITSLTGLQRDSEVLYVGTFSSNEDSVGKRGKISDVFECMEADELDHSD--NRSGY 325
            .::|.||:.....:..:.|:.|          |||..|..|....|...|.|::.|..  ||.|.
Mouse   216 EQLEKDGRSGQRPVMEVFREEE----------EDSFPKDFKEKLHFSVEEDDDVQHESILNRPGL 270

  Fly   326 SSTLARSFSQPDILGDGQLTQELSEEVTLQRPVGLFDRPTMLGSIAFRRSVTAALSQLQLHTDTS 390
            .|.:   ||:..:| |.:...:...|:..:.|..||.|....|::
Mouse   271 GSIV---FSRNRVL-DFEDISDSKRELGFKMPSELFQRQGAAGTV-------------------- 311

  Fly   391 STSTMRNAGSNPPKTRNGGGKGRLYLNLSDDTDSEGGGHDIYSDDDDDDRDAGGSA--------- 446
                                        .::.:.|       .:::::.|:|.|:|
Mouse   312 ----------------------------EEEEEEE-------EEEEEEKREANGTAGDLPWDEEE 341

  Fly   447 ------------LQRFLAVWALEEYLPVFQKQEIDLETLMLLTESDLKSLGLPLGPFRKLTFAIQ 499
                        |:.||....|||:||:|.:::||||.|:|.::.||:::.:.|||.:|:..||.
Mouse   342 VEWEEDAVDATPLEVFLQSQHLEEFLPIFMREQIDLEALLLCSDEDLQNIHMQLGPRKKVLSAID 406

  Fly   500 ERRNALANPGPLVDSRL 516
            :|:..|..||.|||:.|
Mouse   407 KRKQVLQQPGQLVDTSL 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sans	NP_610829.1	ANK	6..118	CDD:238125	57/111 (51%)
		Ank_2	6..96	CDD:289560	49/89 (55%)
		ANK repeat	35..63	CDD:293786	16/27 (59%)
		ANK repeat	65..96	CDD:293786	18/30 (60%)
		Ank_2	70..149	CDD:289560	35/78 (45%)
		SAM_USH1G_HARP	443..508	CDD:188916	27/85 (32%)
		SAM	447..503	CDD:197735	24/55 (44%)
Anks4b	NP_082361.2	Mediates localization to microvilli. /evidence=ECO:0000250\|UniProtKB:Q8N8V4	1..251		102/304 (34%)
		ANK	3..117	CDD:238125	58/113 (51%)
		ANK repeat	3..29	CDD:293786	11/25 (44%)
		Ank_2	6..95	CDD:289560	49/88 (56%)
		ANK repeat	31..62	CDD:293786	18/30 (60%)
		ANK repeat	64..95	CDD:293786	18/30 (60%)
		ANK repeat	97..124	CDD:293786	10/26 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	158..181		7/26 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	207..227		7/24 (29%)
		Mediates interaction with MYO7B. /evidence=ECO:0000269\|PubMed:26812017	253..352		22/157 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	303..335		7/86 (8%)
		SAM_HARP	350..416	CDD:188986	25/65 (38%)
		SAM	357..410	CDD:197735	23/52 (44%)
		PDZ-binding, mediates interaction with USH1C. /evidence=ECO:0000269\|PubMed:15461667	421..423		0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849777
Domainoid	1	1.000	50	1.000	Domainoid score	I11593
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	238	1.000	Inparanoid score	I3357
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50165
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002068
OrthoInspector	1	1.000	-	-		otm43982
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24161
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5090
SonicParanoid	1	1.000	-	-		X2368
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.990