DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sans and Anks4b

DIOPT Version :9

Sequence 1:	NP_610829.1	Gene:	Sans / 36427	FlyBaseID:	FBgn0033785	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001121122.1	Gene:	Anks4b / 687561	RGDID:	1584204	Length:	416	Species:	Rattus norvegicus

Alignment Length:	517	Identity:	162/517 - (31%)
Similarity:	240/517 - (46%)	Gaps:	105/517 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SDRFHKAAKDGLLDVLAAATRKDTNAKDSDSMTPVMWAAFEGRLDALRLLCGRGGDPDKCDQFGN 67
            |.|:|:||.|..|::|..||::|.|..|.|.|||.:.||:.|.|:||.::|.|||||||||.:||
  Rat     2 STRYHQAASDSYLELLKEATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDKCDIWGN 66

  Fly    68 TALHLASAKGHLHCVDFLVKFGVNIYALDIDKHSAKDLAAINGRDEILRYLDVAFTNFEATEKKK 132
            |.||.|::.||.||:.|||.||.||:|||.|..|..|.||...:.|.:..||.|.|....|..||
  Rat    67 TPLHYAASNGHTHCISFLVNFGANIFALDNDLKSPLDAAASREQKECVALLDKAATVQNTTNPKK 131

  Fly   133 SKALKELAEKNCEKRVREYMKRQNQQQQRQDPEYS-DLSAPSGSSKTGNMLSTLKQKIWSSQGNL 196
            ...|||.|.||..::::|..:.|.:.|.:....|| :.|....||::....|:|........|:|
  Rat   132 VARLKEQALKNARRQMKECERLQEKHQNKMARTYSKEDSGTLSSSRSTFSRSSLSNTSVGGFGSL 196

  Fly   197 NKTPRDTPPPTKFSDLVGNGSSSSGGSTIASRAGTVQKRPSQLQKQHSSTCPHSKISSDTDGGFK 261
            :|..:||                                 .:|:         ||.:.||
  Rat   197 SKGIKDT---------------------------------FKLK---------SKKNKDT----- 214

  Fly   262 VREVEPDGKRTITSLTGLQRDSEVLYVGTFSSNEDSVGKRGKISDVFECMEADELDHSD--NRSG 324
            ..::..|||.....:..:.|:.|          |||:.|..|....|...||.::.|..  ||.|
  Rat   215 TEQMGMDGKNGQRPVMEVFREEE----------EDSLPKDFKEKLHFSAEEAGDVQHESILNRPG 269

  Fly   325 YSSTLARSFSQPDILGDGQLTQELSEEVTLQRPVGLFDRPTMLGSIAFRRSVTAALSQLQLHTDT 389
            ..|.:   |::..:|.        .||::..:....|..|:.|    |:|.......:.:...:.
  Rat   270 LGSIV---FNRNRVLD--------LEEISASKRELEFKMPSEL----FQRQGAPGADEEEEEEER 319

  Fly   390 SSTSTMRNAGSNPPKTRNGGGKGRLYLNLSDDTDSEGGGHDIYSDDDDDDRDAGGSALQRFLAVW 454
            .:.||   ||..|                .|:.:.|.         ::|..||  :.|:.||...
  Rat   320 EANST---AGDLP----------------WDEEEVEW---------EEDAIDA--TPLEVFLQSQ 354

  Fly   455 ALEEYLPVFQKQEIDLETLMLLTESDLKSLGLPLGPFRKLTFAIQERRNALANPGPLVDSRL 516
            .|||:||:|.:::||||.|||.::.||:::.|.|||.:|:..||.:|:..|.:||.|||:.|
  Rat   355 HLEEFLPIFMREQIDLEALMLCSDEDLQNIHLQLGPRKKVLNAIDKRKQVLQHPGQLVDTSL 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sans	NP_610829.1	ANK	6..118	CDD:238125	57/111 (51%)
		Ank_2	6..96	CDD:289560	49/89 (55%)
		ANK repeat	35..63	CDD:293786	16/27 (59%)
		ANK repeat	65..96	CDD:293786	18/30 (60%)
		Ank_2	70..149	CDD:289560	36/78 (46%)
		SAM_USH1G_HARP	443..508	CDD:188916	27/64 (42%)
		SAM	447..503	CDD:197735	26/55 (47%)
Anks4b	NP_001121122.1	Ank_4	1..49	CDD:372654	22/46 (48%)
		ANK repeat	3..29	CDD:293786	11/25 (44%)
		ANK repeat	31..62	CDD:293786	18/30 (60%)
		Ank_2	38..121	CDD:403870	44/82 (54%)
		ANK repeat	64..95	CDD:293786	18/30 (60%)
		ANK repeat	97..124	CDD:293786	10/26 (38%)
		CEN_ANKS4B	254..>282	CDD:409641	8/30 (27%)
		SAM_HARP	343..409	CDD:188986	29/67 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353439
Domainoid	1	1.000	52	1.000	Domainoid score	I11162
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50165
OrthoDB	1	1.010	-	-		D1344159at2759
OrthoFinder	1	1.000	-	-		FOG0002068
OrthoInspector	1	1.000	-	-		otm46072
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24161
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2368
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.960