DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sans and Ush1g

DIOPT Version :9

Sequence 1:	NP_610829.1	Gene:	Sans / 36427	FlyBaseID:	FBgn0033785	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001099320.1	Gene:	Ush1g / 287819	RGDID:	1304551	Length:	461	Species:	Rattus norvegicus

Alignment Length:	549	Identity:	179/549 - (32%)
Similarity:	271/549 - (49%)	Gaps:	124/549 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SDRFHKAAKDGLLDVLAAATRKDTNAKDSDSMTPVMWAAFEGRLDALRLLCGRGGDPDKCDQFGN 67
            :|::|:||:||.|::|..||||:.||.|.|.|||.:|||:.|.|::|||:..|||||||||.:||
  Rat     2 NDQYHRAARDGYLELLKEATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGN 66

  Fly    68 TALHLASAKGHLHCVDFLVKFGVNIYALDIDKHSAKDLAAINGRDEILRYLDVAFTNFEATEKKK 132
            |.||||::.|||||:.|||.||.||:.||.|.|:..|:||:.|..|.:||||.......:...|.
  Rat    67 TPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAKQSSLNPKL 131

  Fly   133 SKALKELAEKNCEKRVREYMKRQNQQQQRQDPEY-------SDLSAPSGSSKTGNMLS------T 184
            ...||:.|.:..|:|:||..|.|.:..:|.:..|       ||  ..|.||.|.:.||      |
  Rat   132 VGKLKDKAFREAERRIRECAKMQRKHHERMERRYRRELAERSD--TLSFSSLTSSTLSRRLQHMT 194

  Fly   185 LKQKIWSSQGNLNKTPRDTPPPTKFSDLVGNGSSSSGGSTIASRAGTVQKRPSQLQKQHSSTCPH 249
            |..::..||..|:.|                          |.....:||:   |:::
  Rat   195 LGSQLPYSQATLHGT--------------------------AKGKAKIQKK---LERR------- 223

  Fly   250 SKISSDTDGGFKVREVEPDGKRTITSLTGLQRDSEVLYV--GTFSSNEDSVGKRGKISDVFECME 312
               ....:|.|||.|   ||::::.||:|||..::|::|  ||:::.::  ..|..:.|:|
  Rat   224 ---KQGVEGTFKVSE---DGRKSVRSLSGLQLGNDVMFVRQGTYANPKE--WGRAPLRDMF---- 276

  Fly   313 ADELDHSDNRSGYSSTLARSFSQPDILGDGQLTQELSEEVTLQRPVGLFDRPTMLGSIAFRRSVT 377
                 .||..|...:|||...:..::..|....             .||.||. ||::.|||:..
  Rat   277 -----LSDEDSVSRATLAAEPAHSEVSTDSGHD-------------SLFTRPG-LGTMVFRRNYV 322

  Fly   378 AALSQLQLHTDTSSTSTMRNAGSNPPKTRNGGG-------KGRLYLNLSDDTDSEGGGHDI---- 431
                          :|.:...|      |..||       :|||:.:.|.|.||.|..:.:
  Rat   323 --------------SSGLHGLG------REDGGLDGAGTPRGRLHSSPSLDDDSLGSANSLQDRS 367

  Fly   432 ------YSDDD---DDDRDAGGSALQRFLAVWALEEYLPVFQKQEIDLETLMLLTESDLKSLGLP 487
                  :.:.|   |:|.:...|.|:.|||...:|::..:.:.::||||.|||.::.||:|:.:|
  Rat   368 CGEELPWDELDLGLDEDLEPETSPLETFLASLHMEDFASLLRHEKIDLEALMLCSDLDLRSISVP 432

  Fly   488 LGPFRKLTFAIQERRNALANPGPLVDSRL 516
            |||.:|:..|::.||.||..|..|.|:.|
  Rat   433 LGPRKKILGAVRRRRQALERPLALEDTEL 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sans	NP_610829.1	ANK	6..118	CDD:238125	64/111 (58%)
		Ank_2	6..96	CDD:289560	54/89 (61%)
		ANK repeat	35..63	CDD:293786	17/27 (63%)
		ANK repeat	65..96	CDD:293786	19/30 (63%)
		Ank_2	70..149	CDD:289560	35/78 (45%)
		SAM_USH1G_HARP	443..508	CDD:188916	26/64 (41%)
		SAM	447..503	CDD:197735	22/55 (40%)
Ush1g	NP_001099320.1	ANK	6..117	CDD:238125	64/110 (58%)
		Ank_2	6..91	CDD:289560	52/84 (62%)
		ANK repeat	31..62	CDD:293786	19/30 (63%)
		ANK repeat	64..95	CDD:293786	19/30 (63%)
		Ank_2	69..>117	CDD:289560	26/47 (55%)
		SAM_USH1G	388..453	CDD:188985	26/64 (41%)
		SAM	395..448	CDD:197735	21/52 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353440
Domainoid	1	1.000	52	1.000	Domainoid score	I11162
eggNOG	1	0.900	-	-		E33208_3BEMZ
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56113
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3300
OMA	1	1.010	-	-		QHG50165
OrthoDB	1	1.010	-	-		D1344159at2759
OrthoFinder	1	1.000	-	-		FOG0002068
OrthoInspector	1	1.000	-	-		otm46072
orthoMCL	1	0.900	-	-		OOG6_108131
Panther	1	1.100	-	-	LDO	PTHR24161
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2368
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770