DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sans and ANKS4B

DIOPT Version :9

Sequence 1:	NP_610829.1	Gene:	Sans / 36427	FlyBaseID:	FBgn0033785	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_665872.2	Gene:	ANKS4B / 257629	HGNCID:	26795	Length:	417	Species:	Homo sapiens

Alignment Length:	526	Identity:	162/526 - (30%)
Similarity:	238/526 - (45%)	Gaps:	122/526 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SDRFHKAAKDGLLDVLAAATRKDTNAKDSDSMTPVMWAAFEGRLDALRLLCGRGGDPDKCDQFGN 67
            |.|:|:||.|..|::|..||::|.|..|.|.|||.:.||:.|.|:||.::|.||||||:||.:||
Human     2 STRYHQAASDSYLELLKEATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGN 66

  Fly    68 TALHLASAKGHLHCVDFLVKFGVNIYALDIDKHSAKDLAAINGRDEILRYLDVAFTNFEATEKKK 132
            |.||.|::.||.|||.|||.||.||:|||.|..:..|.||...::|.:..||.|.|.......||
Human    67 TPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDKAATAQNIMNPKK 131

  Fly   133 SKALKELAEKNCEKRVREYMKRQNQQQQRQDPEYSDLSAPSGSSKTGNMLSTLKQKIWSSQGNLN 197
            ...|||.|:||..::::|..:.|.:.|.:....||  ...||:             :.||:|..:
Human   132 VTRLKEQAQKNARRQIKECERLQEKHQNKMAHTYS--KEESGT-------------LSSSKGTFS 181

  Fly   198 K-TPRDTPPPTKFSDLVGNGSSSSGGSTIASRAGTVQKRPSQLQKQHSSTCPHSKISSDTDGGFK 261
            : :|.:...|..|..|                                     ||...||   ||
Human   182 RSSPSNASAPGTFGSL-------------------------------------SKGIKDT---FK 206

  Fly   262 VREVEPDGKRTITSLTGLQRDSEVLYVGTFSSNEDS---VGKRGKISDVFECMEADELDHSDNRS 323
            ::                           |..|:|:   |||.|: |.....||....:..|:.|
Human   207 IK---------------------------FKKNKDTAEQVGKEGR-SGQRNVMEVFREEEEDSFS 243

  Fly   324 G-YSSTLARSFSQPDILGDGQLTQELSEEVTLQRPVGLFDRPTMLGSIAFRRSVTAALSQLQLHT 387
            | :...|..|..:     ||.:..|           .:.:||. ||||.|||:        ::.:
Human   244 GDFKEKLQLSAEE-----DGSVHHE-----------SILNRPG-LGSIVFRRN--------RISS 283

  Fly   388 DTSSTSTMRNAGSNPPK---TRNGGGKGRLYLNLSDDTDSEGGGHDIYSDDDDD---DRD-AGGS 445
            ....:.:.|..|...|.   .|.|..:..  ...:|:...|.|..|....|||:   :.| ...:
Human   284 PEDISDSKREFGFKLPSELLQRQGASEAD--EGAADEEGEENGLKDDLPWDDDEVEWEEDVVDAT 346

  Fly   446 ALQRFLAVWALEEYLPVFQKQEIDLETLMLLTESDLKSLGLPLGPFRKLTFAIQERRNALANPGP 510
            .|:.||....|||:||:|::::||||.|:|.::.||:|:.:.|||.:|:..||..|:..|..||.
Human   347 PLEVFLLSQHLEEFLPIFKREQIDLEALLLCSDEDLQSIQMQLGPRKKVLNAINRRKQVLQQPGQ 411

  Fly   511 LVDSRL 516
            |||:.|
Human   412 LVDTSL 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sans	NP_610829.1	ANK	6..118	CDD:238125	56/111 (50%)
		Ank_2	6..96	CDD:289560	49/89 (55%)
		ANK repeat	35..63	CDD:293786	15/27 (56%)
		ANK repeat	65..96	CDD:293786	19/30 (63%)
		Ank_2	70..149	CDD:289560	35/78 (45%)
		SAM_USH1G_HARP	443..508	CDD:188916	26/64 (41%)
		SAM	447..503	CDD:197735	25/55 (45%)
ANKS4B	NP_665872.2	Mediates localization to microvilli. /evidence=ECO:0000269\|PubMed:26812018	1..252		104/332 (31%)
		ANK	3..117	CDD:238125	57/113 (50%)
		ANK repeat	3..29	CDD:293786	11/25 (44%)
		Ank_2	6..95	CDD:289560	49/88 (56%)
		ANK repeat	31..62	CDD:293786	17/30 (57%)
		ANK repeat	64..95	CDD:293786	19/30 (63%)
		ANK repeat	97..125	CDD:293786	9/27 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..195		11/58 (19%)
		Mediates interaction with MYO7B. /evidence=ECO:0000269\|PubMed:26812018	253..346		26/119 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	305..330		6/26 (23%)
		SAM_HARP	345..410	CDD:188986	26/64 (41%)
		SAM	351..404	CDD:197735	24/52 (46%)
		PDZ-binding, mediates interaction with USH1C. /evidence=ECO:0000269\|PubMed:26812018	415..417		0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159404
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	234	1.000	Inparanoid score	I3414
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50165
OrthoDB	1	1.010	-	-		D1344159at2759
OrthoFinder	1	1.000	-	-		FOG0002068
OrthoInspector	1	1.000	-	-		otm41934
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24161
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5090
SonicParanoid	1	1.000	-	-		X2368
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	12.000