Protein Alignment Sans and USH1G

DIOPT Version :9

• Sequence 1: NP_610829.1
• Gene: Sans / 36427
• FlyBaseID: FBgn0033785
• Length: 516
• Species: Drosophila melanogaster
• Sequence 2: NP_775748.2
• Gene: USH1G / 124590
• HGNCID: 16356
• Length: 461
• Species: Homo sapiens
• Alignment Length: 549
• Identity: 178/549 - (32%)
• Similarity: 268/549 - (48%)
• Gaps: 124/549 - (22%)

  Fly     3 SDRFHKAAKDGLLDVLAAATRKDTNAKDSDSMTPVMWAAFEGRLDALRLLCGRGGDPDKCDQFGN 67
            :|::|:||:||.|::|..||||:.||.|.|.|||.:|||:.|.|::|||:..|||||||||.:||
Human     2 NDQYHRAARDGYLELLKEATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGN 66

  Fly    68 TALHLASAKGHLHCVDFLVKFGVNIYALDIDKHSAKDLAAINGRDEILRYLDVAFTNFEATEKKK 132
            |.||||::.|||||:.|||.||.||:.||.|.|:..|:||:.|..|.:||||.......:...|.
Human    67 TPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAKQSSLNPKL 131

  Fly   133 SKALKELAEKNCEKRVREYMKRQNQQQQRQDPEY-------SDLSAPSGSSKTGNMLS------T 184
            ...||:.|.:..|:|:||..|.|.:..:|.:..|       ||  ..|.||.|.:.||      .
Human   132 VGKLKDKAFREAERRIRECAKLQRRHHERMERRYRRELAERSD--TLSFSSLTSSTLSRRLQHLA 194

  Fly   185 LKQKIWSSQGNLNKTPRDTPPPTKFSDLVGNGSSSSGGSTIASRAGTVQKRPSQLQKQHSSTCPH 249
            |...:..||..|:.|                           :|..|..::..:.:||..
Human   195 LGSHLPYSQATLHGT---------------------------ARGKTKMQKKLERRKQGG----- 227

  Fly   250 SKISSDTDGGFKVREVEPDGKRTITSLTGLQRDSEVLYV--GTFSSNEDSVGKRGKISDVFECME 312
                   :|.|||.|   ||:::..||:|||..|:|::|  ||:::.::  ..|..:.|:|
Human   228 -------EGTFKVSE---DGRKSARSLSGLQLGSDVMFVRQGTYANPKE--WGRAPLRDMF---- 276

  Fly   313 ADELDHSDNRSGYSSTLARSFSQPDILGDGQLTQELSEEVTLQRPVGLFDRPTMLGSIAFRRSVT 377
                 .||..|...:|||...:..::..|....             .||.||. ||::.|||:..
Human   277 -----LSDEDSVSRATLAAEPAHSEVSTDSGHD-------------SLFTRPG-LGTMVFRRNYL 322

  Fly   378 AALSQLQLHTDTSSTSTMRNAGSNPPKTRNGGG-------KGRLYLNLSDDTDSEGGGHDI---- 431
                          :|.:...|      |..||       :|||..:.|.|.||.|..:.:
Human   323 --------------SSGLHGLG------REDGGLDGVGAPRGRLQSSPSLDDDSLGSANSLQDRS 367

  Fly   432 ------YSDDD---DDDRDAGGSALQRFLAVWALEEYLPVFQKQEIDLETLMLLTESDLKSLGLP 487
                  :.:.|   |:|.:...|.|:.|||...:|::..:.::::||||.|||.::.||:|:.:|
Human   368 CGEELPWDELDLGLDEDLEPETSPLETFLASLHMEDFAALLRQEKIDLEALMLCSDLDLRSISVP 432

  Fly   488 LGPFRKLTFAIQERRNALANPGPLVDSRL 516
            |||.:|:..|::.||.|:..|..|.|:.|
Human   433 LGPRKKILGAVRRRRQAMERPPALEDTEL 461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sans	NP_610829.1	ANK	6..118	CDD:238125	64/111 (58%)
		Ank_2	6..96	CDD:289560	54/89 (61%)
		ANK repeat	35..63	CDD:293786	17/27 (63%)
		ANK repeat	65..96	CDD:293786	19/30 (63%)
		Ank_2	70..149	CDD:289560	35/78 (45%)
		SAM_USH1G_HARP	443..508	CDD:188916	25/64 (39%)
		SAM	447..503	CDD:197735	22/55 (40%)
USH1G	NP_775748.2	ANK	6..117	CDD:238125	64/110 (58%)
		ANK repeat	31..62	CDD:293786	19/30 (63%)
		ANK 1	31..60		17/28 (61%)
		ANK repeat	64..95	CDD:293786	19/30 (63%)
		ANK 2	64..93		19/28 (68%)
		ANK 3	97..126		11/28 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	208..243		12/76 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	332..368		10/35 (29%)
		SAM_USH1G	388..453	CDD:188985	25/64 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159405
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BEMZ
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56113
Inparanoid	1	1.050	234	1.000	Inparanoid score	I3414
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50165
OrthoDB	1	1.010	-	-		D1344159at2759
OrthoFinder	1	1.000	-	-		FOG0002068
OrthoInspector	1	1.000	-	-		otm41934
orthoMCL	1	0.900	-	-		OOG6_108131
Panther	1	1.100	-	-	LDO	PTHR24161
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5090
SonicParanoid	1	1.000	-	-		X2368
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.840