DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sans and ush1g

DIOPT Version :9

Sequence 1:	NP_610829.1	Gene:	Sans / 36427	FlyBaseID:	FBgn0033785	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	XP_004918532.1	Gene:	ush1g / 100494764	XenbaseID:	XB-GENE-1013607	Length:	465	Species:	Xenopus tropicalis

Alignment Length:	529	Identity:	177/529 - (33%)
Similarity:	265/529 - (50%)	Gaps:	84/529 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RFHKAAKDGLLDVLAAATRKDTNAKDSDSMTPVMWAAFEGRLDALRLLCGRGGDPDKCDQFGNTA 69
            |:|:||:||.||:|..|||:|.|:.|.|.|||.:|||:.|.|.|||::..|||||||||.:|||.
Frog     4 RYHRAARDGFLDLLKEATRRDLNSPDEDGMTPTLWAAYHGHLGALRVIVSRGGDPDKCDIWGNTP 68

  Fly    70 LHLASAKGHLHCVDFLVKFGVNIYALDIDKHSAKDLAAINGRDEILRYLDVAFTNFEATEKKKSK 134
            ||:|:|.|||:|:.|||.||.||:.||.|.|:..|:||..|..|.:||||...........|...
Frog    69 LHVAAANGHLNCLSFLVSFGANIWCLDNDYHTPLDMAASKGHMECVRYLDSIAAKQTGLNPKLVS 133

  Fly   135 ALKELAEKNCEKRVREYMKRQNQQQQRQDPEY-SDLSAPSGSSKTGNMLSTLKQKIWSSQGNLNK 198
            .|||.|.:..|||:|:..|.|.:..:|.:..| .|:|..|.:....:..|::.|:.
Frog   134 KLKERAFREAEKRIRDCAKLQRKHHERMERRYRRDMSDRSDTMSFSSYSSSVSQRY--------- 189

  Fly   199 TPRDTPPPTKFSDL-VGNGSSSSGGSTIASRAGTVQKRPSQLQKQHSSTCPHSKISSDTDGGFKV 262
                 |..|.|..: ..:.:.::.|.|      .:||:   |:|:           ..|||.||:
Frog   190 -----PSATMFPTMPYSHAAGTTKGKT------KIQKK---LEKR-----------KQTDGMFKI 229

  Fly   263 REVEPDGKRTITSLTGLQRDSEVLYV--GTFSSNEDSVGKRGK--ISDVFECMEADELDHSDNRS 323
            .|   ||::::.||:|||..::|::|  ||::|..:    ||:  :.|:|       |...|
Frog   230 YE---DGRKSVRSLSGLQLGNDVMFVKQGTYASPRE----RGRQHLRDMF-------LPEED--- 277

  Fly   324 GYSSTLARSFSQPDILGDGQLTQELSEEVTLQRPVGLFDRPTMLGSIAFRRSVTAALSQLQLHTD 388
                :|:|:.|.|.:.|......|:|   |......||.||. ||::.|||:        .|.:.
Frog   278 ----SLSRAISDPGLHGGDSAHSEVS---TDSGHDSLFTRPG-LGTMVFRRN--------YLSSG 326

  Fly   389 TSSTSTMRNAGSNPPKTRNGGGKGRLYLNLS-DDTDSEGGGHDIYSDDD----------DDDRDA 442
            ..........|..|........:.||..:.| ||:....|...:.::.:          |||.:.
Frog   327 LFGMGRDEGNGLQPGLGEEVKLRSRLKRSPSLDDSIGSAGSLAVRNEQELPWEEEDLRLDDDEEP 391

  Fly   443 GGSALQRFLAVWALEEYLPVFQKQEIDLETLMLLTESDLKSLGLPLGPFRKLTFAIQERRNALAN 507
            ..|.|:.|||...:.:.:.|.|.::|||..|.|.::.||||:|:||||.:|:...||.||.|:..
Frog   392 DTSPLESFLASLQMGDLVTVLQDEKIDLAALTLCSDHDLKSIGIPLGPRKKILDGIQRRRQAIDR 456

  Fly   508 PGPLVDSRL 516
            |..:.|:.|
Frog   457 PSTMGDTEL 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sans	NP_610829.1	ANK	6..118	CDD:238125	63/111 (57%)
		Ank_2	6..96	CDD:289560	53/89 (60%)
		ANK repeat	35..63	CDD:293786	17/27 (63%)
		ANK repeat	65..96	CDD:293786	18/30 (60%)
		Ank_2	70..149	CDD:289560	36/78 (46%)
		SAM_USH1G_HARP	443..508	CDD:188916	27/64 (42%)
		SAM	447..503	CDD:197735	24/55 (44%)
ush1g	XP_004918532.1	Ank_4	5..49	CDD:372654	24/43 (56%)
		ANK repeat	31..62	CDD:293786	19/30 (63%)
		Ank_2	38..117	CDD:372319	45/78 (58%)
		ANK repeat	64..95	CDD:293786	18/30 (60%)
		SAM_USH1G	392..457	CDD:188985	27/64 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I11132
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H56113
Inparanoid	1	1.050	242	1.000	Inparanoid score	I3238
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1344159at2759
OrthoFinder	1	1.000	-	-		FOG0002068
OrthoInspector	1	1.000	-	-		otm49156
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5090
SonicParanoid	1	1.000	-	-		X2368
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.090