Protein Alignment CG17019 and RNF34

DIOPT Version :9

• Sequence 1: NP_001286365.1
• Gene: CG17019 / 36425
• FlyBaseID: FBgn0033783
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_001381137.1
• Gene: RNF34 / 80196
• HGNCID: 17297
• Length: 373
• Species: Homo sapiens
• Alignment Length: 713
• Identity: 134/713 - (18%)
• Similarity: 198/713 - (27%)
• Gaps: 417/713 - (58%)

  Fly     3 CESCGVEFTVFRRKRACFDCKRYYCANCIA----SRRCKRCSVFAQRPLSRTDLLKLKPKDLIFY 63
            |::||:.|:|||:|..|.|||:.:|:.|..    .|||..|.:..:....|..|::||.|||..|
Human    63 CKACGLSFSVFRKKHVCCDCKKDFCSVCSVLQENLRRCSTCHLLQETAFQRPQLMRLKVKDLRQY 127

  Fly    64 LQSKHISTEGCLEKEELVGLVLTHVAQVDRSRGS----NASSNSPGRGQANPIDSLKQSCQNFFS 124
            |..::|..:.|.|||:||.|||.|     ...||    :.||.:..|.|.:...:     ::|||
Human   128 LILRNIPIDTCREKEDLVDLVLCH-----HGLGSEDDMDTSSLNSSRSQTSSFFT-----RSFFS 182

  Fly   125 NLSDNISDSLASFDSKVTTKPPESRQPEVPTHIFEQPRVSTREIPTYASAVNGGPQHVHVQQQAT 189
            |.:.. |.:::||..::......||                          :|.|  ..||.:.|
Human   183 NYTAP-SATMSSFQGELMDGDQTSR--------------------------SGVP--AQVQSEIT 218

  Fly   190 TTNGGSQSSSSPSTSTQSSNNRDASSSSQAHVAHQEARNEEQEDAQSKSDCECSDEEIMATFSER 254
            :.|            |:..::.|           .|..::|:|:|:.:
Human   219 SAN------------TEDDDDDD-----------DEDDDDEEENAEDR----------------- 243

  Fly   255 VSISLKTDTSGRRVNAAAEPSPVDLANVDNGPAGNTAPSPGCSKPGSSSSKADASSQSSFEELGA 319
                                                  :||.||
Human   244 --------------------------------------NPGLSK--------------------- 249

  Fly   320 IGGISDESKANTDTNSSHLDQWQVLEVNRIEAVEETPTTSAADEILEVTLRSRPAVEGDDSEMGE 384
                                                                             
Human   250 ----------------------------------------------------------------- 249

  Fly   385 STQALNVNQRPANPSPAFYPAVPQRTKKVTRRRSDGYLNRRYHSSDDESPVAPGGPGLSLGLSTL 449
                                                                             
Human   250 ----------------------------------------------------------------- 249

  Fly   450 SEHPEHGLHPHSHRQSCQRCGKNKTNIRRHVEKMRRHLENSQMSEEDIKRELQEFLTYLEQRTKS 514
                                           |::|
Human   250 -------------------------------ERVR------------------------------ 253

  Fly   515 VDASDADSHAVSPLSVDAISVAAGGRSPDMPITPTIEFSPTQDEDIRWDDDEGIHVYAAPSDFEP 579
                                                                             
Human   254 ----------------------------------------------------------------- 253

  Fly   580 TAGIDSRFVNLEDFEDLKDLEGLTVKQLKEVLMLHRVDYKGCCEKQELLDRVSRLWKTMRECPAV 644
                    .:|.|...|.|:||::|:||||:|..:.|:|.|||||.||:::|:||:|...|....
Human   254 --------ASLSDLSSLDDVEGMSVRQLKEILARNFVNYSGCCEKWELVEKVNRLYKENEENQKS 310

  Fly   645 --EKL-----ATDELCKICMDAPIECVFLECGHMATCTSCGKVLNECPICRQYIVRVVRFFRA 700
              |:|     ..|.||:|||||.|:||.||||||.|||.|||.::||||||||:||.|..|::
Human   311 YGERLQLQDEEDDSLCRICMDAVIDCVLLECGHMVTCTKCGKRMSECPICRQYVVRAVHVFKS 373

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17019	NP_001286365.1	FYVE_CARP	1..42	CDD:277289	18/42 (43%)
		zf-C3HC4_3	650..694	CDD:290631	32/43 (74%)
RNF34	NP_001381137.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146817
Domainoid	1	1.000	147	1.000	Domainoid score	I4518
eggNOG	1	0.900	-	-		E1_KOG4275
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	221	1.000	Inparanoid score	I3556
Isobase	1	0.950	-	0	Normalized mean entropy	S7198
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1361306at2759
OrthoFinder	1	1.000	-	-		FOG0002853
OrthoInspector	1	1.000	-	-		otm40252
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14879
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4872
SonicParanoid	1	1.000	-	-		X1893
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.840