Protein Alignment CG17019 and RFFL

DIOPT Version :10

• Sequence 1: NP_610827.2
• Gene: CG17019 / 36425
• FlyBaseID: FBgn0033783
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_001017368.1
• Gene: RFFL / 117584
• HGNCID: 24821
• Length: 363
• Species: Homo sapiens
• Alignment Length: 718
• Identity: 153/718 - (21%)
• Similarity: 200/718 - (27%)
• Gaps: 421/718 - (58%)

  Fly     3 CESCGVEFTVFRRKRACFDCKRYYCANCIAS-----RRCKRCSVFAQRPLSRTDLLKLKPKDLIF 62
            |:|||..|....||:.|.|||:.:|..|.:.     |.|..|..|......|.:|:|:|.|||..
Human    47 CKSCGAHFANTARKQTCLDCKKNFCMTCSSQVGNGPRLCLLCQRFRATAFQREELMKMKVKDLRD 111

  Fly    63 YLQSKHISTEGCLEKEELVGLVLTH---VAQVDRSRGSNASSNSPGRGQANPIDSLKQSCQNFFS 124
            ||....||||.|.||||||.|||..   ::|.||:|.|..|
Human   112 YLSLHDISTEMCREKEELVLLVLGQQPVISQEDRTRASTLS------------------------ 152

  Fly   125 NLSDNISDSLASFDSKVTTKPPESRQPEVPTHIFEQPRVSTREIPTYASAVNGGPQHVHVQQQAT 189
                                      |:.|                              :|||.
Human   153 --------------------------PDFP------------------------------EQQAF 161

  Fly   190 TTNGGSQSSSSPSTSTQSSNNRDASSSSQAHVAHQEARNEEQEDAQSKSDCECSDEEIMATFSER 254
            .|.  ..||..|.||
Human   162 LTQ--PHSSMVPPTS-------------------------------------------------- 174

  Fly   255 VSISLKTDTSGRRVNAAAEPSPVDLANVDNGPAGNTAPSPGCSKPGSSSSKADASSQSSFEELGA 319
                                                        |...||.|.|:|
Human   175 --------------------------------------------PNLPSSSAQATS--------- 186

  Fly   320 IGGISDESKANTDTNSSHLDQWQVLEVNRIEAVEETPTTSAADEILEVTLRSRPAVEGDDSEMGE 384
                                               .|                ||      ::.|
Human   187 -----------------------------------VP----------------PA------QVQE 194

  Fly   385 STQALNVNQRPANPSPAFYPAVPQRTKKVTRRRSDGYLNRRYHSSDDESPVAPGGPGLSLGLSTL 449
            :.||                              :|::     |.|.|.||
Human   195 NQQA------------------------------NGHV-----SQDQEEPV-------------- 210

  Fly   450 SEHPEHGLHPHSHRQSCQRCGKNKTNIRRHVEKMRRHLENSQMSEEDIKRELQEFLTYLEQRTKS 514
                                         ::|.:.|                    ...|..|:|
Human   211 -----------------------------YLESVAR--------------------VPAEDETQS 226

  Fly   515 VDASDADSHAVSPLSVDAISVAAGGRSPDMPITPTIEFSPTQDEDIRWDDDEGIHVYAAPSDFEP 579
            :|:.|:                                                        |.|
Human   227 IDSEDS--------------------------------------------------------FVP 235

  Fly   580 TAGIDSRFVNLEDFEDLKDLEGLTVKQLKEVLMLHRVDYKGCCEKQELLDRVSRLWKTMRECPAV 644
                 .|..:|.|..||:|:|||||:||||:|..:.|:|||||||.||::||:||:|..:....:
Human   236 -----GRRASLSDLTDLEDIEGLTVRQLKEILARNFVNYKGCCEKWELMERVTRLYKDQKGLQHL 295

  Fly   645 EKLATDE------------LCKICMDAPIECVFLECGHMATCTSCGKVLNECPICRQYIVRVVRF 697
            ...|.|:            |||||||:||:||.||||||.|||.|||.:|||||||||::|.|..
Human   296 VSGAEDQNGGAVPSGLEENLCKICMDSPIDCVLLECGHMVTCTKCGKRMNECPICRQYVIRAVHV 360

  Fly   698 FRA 700
            ||:
Human   361 FRS 363

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17019	NP_610827.2	FYVE_CARP	1..42	CDD:277289	16/43 (37%)
		RING-HC_CARP	651..698	CDD:438163	34/58 (59%)
RFFL	NP_001017368.1	FYVE_CARP2	44..92	CDD:277309	16/44 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	165..209		21/238 (9%)
		RING-HC_CARP2	312..361	CDD:438367	34/48 (71%)