DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sug and ZIC5

DIOPT Version :9

Sequence 1:	NP_610826.1	Gene:	sug / 36424	FlyBaseID:	FBgn0033782	Length:	384	Species:	Drosophila melanogaster
Sequence 2:	NP_149123.3	Gene:	ZIC5 / 85416	HGNCID:	20322	Length:	639	Species:	Homo sapiens

Alignment Length:	350	Identity:	106/350 - (30%)
Similarity:	146/350 - (41%)	Gaps:	89/350 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 AAYSDSGSWLADHHQHHQQQHQQHQQQMQHIRFPTPPITPPRPIAGYGYRQRTQSVIMKARGQQD 100
            ||.:.:.:....|.|||                 .||..||.|.|...:..:....:..|.|...
Human   314 AAAAAAAAGPGPHLQHH-----------------APPPAPPPPPAPAQHPHQHHPHLPGAAGAFL 361

  Fly   101 ELCRSPVEFPDDSKSCSSSSECGTASDFVCNWTD----------------------------CDR 137
            ...|.|::                 .:.:|.|.|                            |.:
Human   362 RYMRQPIK-----------------QELICKWIDPDELAGLPPPPPPPPPPPPPPPAGGAKPCSK 409

  Fly   138 VFDTLDALAQHVTQRHAIASLTDGLYYCRWRGCQRSERGFNARYKMLVHTRTHTKEKPHRCHL-- 200
            .|.|:..|..|||..| :.......:.|.|..|.|..:.|.|:||::.|.|.||.|||..|..
Human   410 TFGTMHELVNHVTVEH-VGGPEQSSHVCFWEDCPREGKPFKAKYKLINHIRVHTGEKPFPCPFPG 473

  Fly   201 CEKSFSRAENLKIHIRSHSGEKPYKCSFEGCQKAYSNSSDRFKHTRTHSMEKPYMCKVAGCQKRY 265
            |.|.|:|:||||||.|:|:||||:||.|:||.:.::|||||.||:..|:.:|||.||:.||.|.|
Human   474 CGKVFARSENLKIHKRTHTGEKPFKCEFDGCDRKFANSSDRKKHSHVHTSDKPYYCKIRGCDKSY 538

  Fly   266 TDPSSLRKHVKTFKHSIHL-------------IASQPLTLPSVPCLLEASSESAFTCLPAASSVE 317
            |.|||||||:|     ||.             ....|:..|..|.|..|.|.|: |..|..:::.
Human   539 THPSSLRKHMK-----IHCKSPPPSPGPLGYSSVGTPVGAPLSPVLDPARSHSS-TLSPQVTNLN 597

  Fly   318 -----STSSSSSARYYDDSNNEPSD 337
                 ..|.:.|..:...||...|:
Human   598 EWYVCQASGAPSHLHTPSSNGTTSE 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sug	NP_610826.1	C2H2 Zn finger	170..190	CDD:275368	8/19 (42%)
		zf-H2C2_2	183..207	CDD:290200	11/25 (44%)
		COG5048	192..>271	CDD:227381	45/80 (56%)
		C2H2 Zn finger	198..218	CDD:275368	12/21 (57%)
		zf-H2C2_2	210..237	CDD:290200	16/26 (62%)
		C2H2 Zn finger	226..248	CDD:275368	11/21 (52%)
		C2H2 Zn finger	256..277	CDD:275368	14/20 (70%)
ZIC5	NP_149123.3	zf_ZIC	366..429	CDD:408166	12/80 (15%)
		COG5048	<405..551	CDD:227381	71/151 (47%)
		C2H2 Zn finger	441..461	CDD:275368	8/19 (42%)
		C2H2 Zn finger	469..491	CDD:275368	12/21 (57%)
		C2H2 Zn finger	499..521	CDD:275368	11/21 (52%)
		C2H2 Zn finger	529..551	CDD:275368	15/26 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X217
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910