DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sug and GLIS2

DIOPT Version :9

Sequence 1:	NP_610826.1	Gene:	sug / 36424	FlyBaseID:	FBgn0033782	Length:	384	Species:	Drosophila melanogaster
Sequence 2:	NP_001305847.1	Gene:	GLIS2 / 84662	HGNCID:	29450	Length:	524	Species:	Homo sapiens

Alignment Length:	229	Identity:	109/229 - (47%)
Similarity:	129/229 - (56%)	Gaps:	43/229 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 ITPPRPIAGYGYRQRTQSVIMKARGQQDELCRSPVEFPDDSKSCSSSSECGTASDFVCNWTDCDR 137
            :|||:                       :.|.|| :.|             .....||.|..|::
Human   150 LTPPK-----------------------DKCLSP-DLP-------------LPKQLVCRWAKCNQ 177

  Fly   138 VFDTLDALAQHVTQRHAIASLTDGLYYCRWRGCQRSERGFNARYKMLVHTRTHTKEKPHRCHLCE 202
            :|:.|..|..||...| :....|..|.|.|.||.|..||||||||||:|.||||.||||||..|.
Human   178 LFELLQDLVDHVNDYH-VKPEKDAGYCCHWEGCARHGRGFNARYKMLIHIRTHTNEKPHRCPTCS 241

  Fly   203 KSFSRAENLKIHIRSHSGEKPYKCSFEGCQKAYSNSSDRFKHTRTHSMEKPYMCKVAGCQKRYTD 267
            |||||.||||||.|||:|||||.|.:|||.|.||||||||||||||.::|||.||:.||.|||||
Human   242 KSFSRLENLKIHNRSHTGEKPYVCPYEGCNKRYSNSSDRFKHTRTHYVDKPYYCKMPGCHKRYTD 306

  Fly   268 PSSLRKHVKTFKHSI-----HLIASQPLTLPSVP 296
            |||||||:|...|.:     .|:..:|...|.:|
Human   307 PSSLRKHIKAHGHFVSHEQQELLQLRPPPKPPLP 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sug	NP_610826.1	C2H2 Zn finger	170..190	CDD:275368	14/19 (74%)
		zf-H2C2_2	183..207	CDD:290200	17/23 (74%)
		COG5048	192..>271	CDD:227381	59/78 (76%)
		C2H2 Zn finger	198..218	CDD:275368	14/19 (74%)
		zf-H2C2_2	210..237	CDD:290200	19/26 (73%)
		C2H2 Zn finger	226..248	CDD:275368	17/21 (81%)
		C2H2 Zn finger	256..277	CDD:275368	16/20 (80%)
GLIS2	NP_001305847.1	Interaction with CTNND1. /evidence=ECO:0000250	35..174		10/60 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..62
		Transcription activation. /evidence=ECO:0000250	71..137
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	84..114
		Transcription repression. /evidence=ECO:0000250	148..171		8/57 (14%)
		C2H2 Zn finger	213..229	CDD:275368	12/15 (80%)
		COG5048	233..>327	CDD:227381	65/93 (70%)
		C2H2 Zn finger	237..257	CDD:275368	14/19 (74%)
		C2H2 Zn finger	265..287	CDD:275368	17/21 (81%)
		C2H2 Zn finger	295..317	CDD:275368	17/21 (81%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	439..480
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158700
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BJB2
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2875
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006993
OrthoInspector	1	1.000	-	-		oto91084
orthoMCL	1	0.900	-	-		OOG6_109933
Panther	1	1.100	-	-	LDO	PTHR19818
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4587
SonicParanoid	1	1.000	-	-		X217
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.680