DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sug and ZIC4

DIOPT Version :9

Sequence 1:	NP_610826.1	Gene:	sug / 36424	FlyBaseID:	FBgn0033782	Length:	384	Species:	Drosophila melanogaster
Sequence 2:	NP_001161850.1	Gene:	ZIC4 / 84107	HGNCID:	20393	Length:	384	Species:	Homo sapiens

Alignment Length:	355	Identity:	107/355 - (30%)
Similarity:	154/355 - (43%)	Gaps:	72/355 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IQKSIFNSGPHSRGIYEPPLGYFTPYNTPPYIAAYSDSGSWLADHHQHHQQQHQQHQQQMQHIRF 68
            :::|..:||.|.                 |.:.|.|....:...|.:..|....:....:..:..
Human    70 LKESSSSSGHHG-----------------PQLTAASSPSVFPGLHEEPPQASPSRPLNGLLRLGL 117

  Fly    69 P-----TPPITPPRPIA------------GYGYRQRTQSVIM-KARGQQDELCRSPVEFPDDSKS 115
            |     .|...||.|.|            |||....|.::.. ...|......|.|::
Human   118 PGDMYARPEPFPPGPAARSDALAAAAALHGYGGMNLTVNLAAPHGPGAFFRYMRQPIK------- 175

  Fly   116 CSSSSECGTASDFVCNW---------TDCDRVFDTLDALAQHVTQRHAIASLTDGLYYCRWRGCQ 171
                      .:.:|.|         :.|.:.|.|:..|..|||..| :.......:.|.|..|.
Human   176 ----------QELICKWLAADGTATPSLCSKTFSTMHELVTHVTVEH-VGGPEQANHICFWEECP 229

  Fly   172 RSERGFNARYKMLVHTRTHTKEKPHRCHL--CEKSFSRAENLKIHIRSHSGEKPYKCSFEGCQKA 234
            |..:.|.|:||::.|.|.||.|||..|..  |.|.|:|:||||||.|:|:||||::|.||||::.
Human   230 RQGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFRCEFEGCERR 294

  Fly   235 YSNSSDRFKHTRTHSMEKPYMCKVAGCQKRYTDPSSLRKHVKTFKHSIHLIASQPLTLPSVPCLL 299
            ::|||||.||:..|:.:|||.|||.||.|.||.|||||||:|....|....:......||  .|:
Human   295 FANSSDRKKHSHVHTSDKPYTCKVRGCDKCYTHPSSLRKHMKVHGRSPPPSSGYDSATPS--ALV 357

  Fly   300 EASSESAFTCLPAASSVESTSSSSSARYYD 329
            ..||:...      .|..::|::.:||..|
Human   358 SPSSDCGH------KSQVASSAAVAARTAD 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sug	NP_610826.1	C2H2 Zn finger	170..190	CDD:275368	8/19 (42%)
		zf-H2C2_2	183..207	CDD:290200	11/25 (44%)
		COG5048	192..>271	CDD:227381	46/80 (58%)
		C2H2 Zn finger	198..218	CDD:275368	12/21 (57%)
		zf-H2C2_2	210..237	CDD:290200	16/26 (62%)
		C2H2 Zn finger	226..248	CDD:275368	12/21 (57%)
		C2H2 Zn finger	256..277	CDD:275368	15/20 (75%)
ZIC4	NP_001161850.1	COG5048	<192..338	CDD:227381	72/146 (49%)
		C2H2 Zn finger	228..248	CDD:275368	8/19 (42%)
		zf-H2C2_2	241..267	CDD:290200	11/25 (44%)
		C2H2 Zn finger	256..278	CDD:275368	12/21 (57%)
		zf-H2C2_2	270..297	CDD:290200	16/26 (62%)
		C2H2 Zn finger	286..308	CDD:275368	12/21 (57%)
		zf-C2H2	314..338	CDD:278523	17/23 (74%)
		C2H2 Zn finger	316..338	CDD:275368	16/21 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X217
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910