DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sug and ZIC3

DIOPT Version :9

Sequence 1:	NP_610826.1	Gene:	sug / 36424	FlyBaseID:	FBgn0033782	Length:	384	Species:	Drosophila melanogaster
Sequence 2:	NP_003404.1	Gene:	ZIC3 / 7547	HGNCID:	12874	Length:	467	Species:	Homo sapiens

Alignment Length:	421	Identity:	122/421 - (28%)
Similarity:	169/421 - (40%)	Gaps:	130/421 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 AAYSDSGSWLAD--HHQHHQQQHQQHQQQM----------------------------------Q 64
            :|::..||..|:  .|.||...|..|..|:                                  |
Human    72 SAFTPQGSGYANALGHHHHHHHHHHHTSQVPSYGGAASAAFNSTREFLFRQRSSGLSEAASGGGQ 136

  Fly    65 HIRF-------------PTPP---ITPPRPIAGYGYRQRT-----QSVIMKARGQ---------- 98
            |..|             |.||   :.|.....|.|:...|     ..|.:..||:
Human   137 HGLFAGSASSLHAPAGIPEPPSYLLFPGLHEQGAGHPSPTGHVDNNQVHLGLRGELFGRADPYRP 201

  Fly    99 ----QDELCRSPVEFPDDS-----KSCSSSSECGTASDF-----------VCNWTD--------- 134
                :.:...:..:||:.|     ...:.::..|..:.|           .|.|.|
Human   202 VASPRTDPYAAGAQFPNYSPMNMNMGVNVAAHHGPGAFFRYMRQPIKQELSCKWIDEAQLSRPKK 266

  Fly   135 -CDRVFDTLDALAQHVTQRHAIASLTDGLYYCRWRGCQRSERGFNARYKMLVHTRTHTKEKPHRC 198
             |||.|.|:..|..|||..| :.......:.|.|..|.|..:.|.|:||::.|.|.||.|||..|
Human   267 SCDRTFSTMHELVTHVTMEH-VGGPEQNNHVCYWEECPREGKSFKAKYKLVNHIRVHTGEKPFPC 330

  Fly   199 HL--CEKSFSRAENLKIHIRSHSGEKPYKCSFEGCQKAYSNSSDRFKHTRTHSMEKPYMCKVAGC 261
            ..  |.|.|:|:||||||.|:|:||||:||.||||.:.::|||||.||...|:.:|||:|||  |
Human   331 PFPGCGKIFARSENLKIHKRTHTGEKPFKCEFEGCDRRFANSSDRKKHMHVHTSDKPYICKV--C 393

  Fly   262 QKRYTDPSSLRKHVKTFKHSIHLIASQPLTLPSVPCLLEASSESAFTCLPAASS--VESTSSSSS 324
            .|.||.|||||||:|     :|  .||             .|:|:    |||||  ..||..:.:
Human   394 DKSYTHPSSLRKHMK-----VH--ESQ-------------GSDSS----PAASSGYESSTPPAIA 434

  Fly   325 ARYYDDSNNEPSDYSLKPKQDAEFSPSY--W 353
            :....|:...||........:....|::  |
Human   435 SANSKDTTKTPSAVQTSTSHNPGLPPNFNEW 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sug	NP_610826.1	C2H2 Zn finger	170..190	CDD:275368	8/19 (42%)
		zf-H2C2_2	183..207	CDD:290200	11/25 (44%)
		COG5048	192..>271	CDD:227381	46/80 (58%)
		C2H2 Zn finger	198..218	CDD:275368	12/21 (57%)
		zf-H2C2_2	210..237	CDD:290200	17/26 (65%)
		C2H2 Zn finger	226..248	CDD:275368	12/21 (57%)
		C2H2 Zn finger	256..277	CDD:275368	14/20 (70%)
ZIC3	NP_003404.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	66..107		10/34 (29%)
		Nuclear localization signal	297..322		10/24 (42%)
		C2H2 Zn finger	302..322	CDD:275368	8/19 (42%)
		SFP1	<324..408	CDD:227516	51/85 (60%)
		C2H2 Zn finger	330..352	CDD:275368	12/21 (57%)
		Nuclear localization signal	330..352		12/21 (57%)
		C2H2 Zn finger	360..382	CDD:275368	12/21 (57%)
		C2H2 Zn finger	390..410	CDD:275368	15/26 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	404..467		21/86 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X217
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910