DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sug and ZIC2

DIOPT Version :9

Sequence 1:	NP_610826.1	Gene:	sug / 36424	FlyBaseID:	FBgn0033782	Length:	384	Species:	Drosophila melanogaster
Sequence 2:	NP_009060.2	Gene:	ZIC2 / 7546	HGNCID:	12873	Length:	532	Species:	Homo sapiens

Alignment Length:	341	Identity:	106/341 - (31%)
Similarity:	156/341 - (45%)	Gaps:	81/341 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 IFNSGPHSRGIYEPPLGYFTPYNTPPYIAA--YSDSG----------SWLADHHQHHQQQHQQHQ 60
            :|......|.:..|        .|.||.||  ::..|          :..|.||.||...|
Human   187 VFGRSEQYRQVASP--------RTDPYSAAQLHNQYGPMNMNMGMNMAAAAAHHHHHHHHH---- 239

  Fly    61 QQMQHIRFPTPPITPPRPIAGYGYRQRTQSVIMKARGQQDELCR--SPVEFPDDSKSCSSSSECG 123
                             |.|.:.| .|.|.:      :|:.:|:  .|.:..:..||
Human   240 -----------------PGAFFRY-MRQQCI------KQELICKWIDPEQLSNPKKS-------- 272

  Fly   124 TASDFVCNWTDCDRVFDTLDALAQHVTQRHAIASLTDGLYYCRWRGCQRSERGFNARYKMLVHTR 188
                       |::.|.|:..|..||:..| :.......:.|.|..|.|..:.|.|:||::.|.|
Human   273 -----------CNKTFSTMHELVTHVSVEH-VGGPEQSNHVCFWEECPREGKPFKAKYKLVNHIR 325

  Fly   189 THTKEKPHRCHL--CEKSFSRAENLKIHIRSHSGEKPYKCSFEGCQKAYSNSSDRFKHTRTHSME 251
            .||.|||..|..  |.|.|:|:||||||.|:|:||||::|.||||.:.::|||||.||...|:.:
Human   326 VHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFQCEFEGCDRRFANSSDRKKHMHVHTSD 390

  Fly   252 KPYMCKVAGCQKRYTDPSSLRKHVKTFKHSIHLIASQPLT-----LPSVPCLLEASSE--SAFTC 309
            |||:||:  |.|.||.|||||||:|..:.|.....|.|..     ..:.|.|:..|:|  |:...
Human   391 KPYLCKM--CDKSYTHPSSLRKHMKVHESSPQGSESSPAASSGYESSTPPGLVSPSAEPQSSSNL 453

  Fly   310 LPAASSVESTSSSSSA 325
            .|||::..:.:::::|
Human   454 SPAAAAAAAAAAAAAA 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sug	NP_610826.1	C2H2 Zn finger	170..190	CDD:275368	8/19 (42%)
		zf-H2C2_2	183..207	CDD:290200	11/25 (44%)
		COG5048	192..>271	CDD:227381	44/80 (55%)
		C2H2 Zn finger	198..218	CDD:275368	12/21 (57%)
		zf-H2C2_2	210..237	CDD:290200	16/26 (62%)
		C2H2 Zn finger	226..248	CDD:275368	12/21 (57%)
		C2H2 Zn finger	256..277	CDD:275368	13/20 (65%)
ZIC2	NP_009060.2	Necessary for interaction with MDFIC and transcriptional activation or repression. /evidence=ECO:0000250	100..255		20/103 (19%)
		zf_ZIC	250..295	CDD:408166	13/70 (19%)
		C2H2 Zn finger	307..327	CDD:275368	8/19 (42%)
		SFP1	<329..413	CDD:227516	49/85 (58%)
		C2H2 Zn finger	335..357	CDD:275368	12/21 (57%)
		C2H2 Zn finger	365..387	CDD:275368	12/21 (57%)
		C2H2 Zn finger	395..415	CDD:275368	14/21 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	406..452		15/45 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	475..532
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X217
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910