DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sug and ZIC1

DIOPT Version :9

Sequence 1:	NP_610826.1	Gene:	sug / 36424	FlyBaseID:	FBgn0033782	Length:	384	Species:	Drosophila melanogaster
Sequence 2:	NP_003403.2	Gene:	ZIC1 / 7545	HGNCID:	12872	Length:	447	Species:	Homo sapiens

Alignment Length:	373	Identity:	117/373 - (31%)
Similarity:	160/373 - (42%)	Gaps:	92/373 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QKSIFNS------GPHSR----------GIYEPPLGYFTPYNTPPYIAAYSDSGSWLADHHQHHQ 53
            |.|:|.:      |||..          |::|...|:.:| |..........||    |.:...:
Human   117 QHSLFAASAGGFGGPHGHTDAAGHLLFPGLHEQAAGHASP-NVVNGQMRLGFSG----DMYPRPE 176

  Fly    54 QQHQQHQQQMQHIRFPTPPITPPRPIAGYGYRQRTQSVIMKAR---GQQDELCRSPVEFPDDSKS 115
            |..|....:.:|...|        .:.|||    ..:|.|.|.   |......|.|::
Human   177 QYGQVTSPRSEHYAAP--------QLHGYG----PMNVNMAAHHGAGAFFRYMRQPIK------- 222

  Fly   116 CSSSSECGTASDFVCNWTD----------CDRVFDTLDALAQHVTQRHAIASLTDGLYYCRWRGC 170
                      .:.:|.|.:          |::.|.|:..|..|||..| :.......:.|.|..|
Human   223 ----------QELICKWIEPEQLANPKKSCNKTFSTMHELVTHVTVEH-VGGPEQSNHICFWEEC 276

  Fly   171 QRSERGFNARYKMLVHTRTHTKEKPHRCHL--CEKSFSRAENLKIHIRSHSGEKPYKCSFEGCQK 233
            .|..:.|.|:||::.|.|.||.|||..|..  |.|.|:|:||||||.|:|:||||:||.||||.:
Human   277 PREGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFKCEFEGCDR 341

  Fly   234 AYSNSSDRFKHTRTHSMEKPYMCKVAGCQKRYTDPSSLRKHVKTFKHSIHLIASQPLTLPSVPCL 298
            .::|||||.||...|:.:|||:||:  |.|.||.|||||||:|..:.|..  .|||
Human   342 RFANSSDRKKHMHVHTSDKPYLCKM--CDKSYTHPSSLRKHMKVHESSSQ--GSQP--------- 393

  Fly   299 LEASSESAFTCLPAASSVESTSSSSSARYYDDSNNEPSDYSLKPKQDA 346
                       .|||||  ...||:.......|.:.|:..||.|...|
Human   394 -----------SPAASS--GYESSTPPTIVSPSTDNPTTSSLSPSSSA 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sug	NP_610826.1	C2H2 Zn finger	170..190	CDD:275368	8/19 (42%)
		zf-H2C2_2	183..207	CDD:290200	11/25 (44%)
		COG5048	192..>271	CDD:227381	45/80 (56%)
		C2H2 Zn finger	198..218	CDD:275368	12/21 (57%)
		zf-H2C2_2	210..237	CDD:290200	17/26 (65%)
		C2H2 Zn finger	226..248	CDD:275368	12/21 (57%)
		C2H2 Zn finger	256..277	CDD:275368	13/20 (65%)
ZIC1	NP_003403.2	zf_ZIC	219..264	CDD:408166	11/62 (18%)
		C2H2 Zn finger	276..296	CDD:275368	8/19 (42%)
		SFP1	<298..382	CDD:227516	50/85 (59%)
		C2H2 Zn finger	304..326	CDD:275368	12/21 (57%)
		C2H2 Zn finger	334..356	CDD:275368	12/21 (57%)
		C2H2 Zn finger	364..384	CDD:275368	14/21 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	375..431		24/78 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X217
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910