DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sug and Zic5

DIOPT Version :9

Sequence 1:	NP_610826.1	Gene:	sug / 36424	FlyBaseID:	FBgn0033782	Length:	384	Species:	Drosophila melanogaster
Sequence 2:	NP_075363.1	Gene:	Zic5 / 65100	MGIID:	1929518	Length:	622	Species:	Mus musculus

Alignment Length:	308	Identity:	103/308 - (33%)
Similarity:	138/308 - (44%)	Gaps:	68/308 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 AAYSDSGSWLADHHQHHQQQHQQHQQQMQHIRFPTPPITPPRPIAGYGYRQRTQSVIMKARGQQD 100
            ||.:.:.:....|.|||                ..||..||.| |.:.:...    :..|.|...
Mouse   312 AAAAAAAAGPGPHLQHH----------------APPPAPPPAP-APHPHHPH----LPGAAGAFL 355

  Fly   101 ELCRSPVEFPDDSKSCSSSSECGTASDFVCNWTD-----------------CDRVFDTLDALAQH 148
            ...|.|::                 .:.:|.|.|                 |.:.|.|:..|..|
Mouse   356 RYMRQPIK-----------------RELICKWLDPEELAGPPASADSGVKPCSKTFGTMHELVNH 403

  Fly   149 VTQRHAIASLTDGLYYCRWRGCQRSERGFNARYKMLVHTRTHTKEKPHRCHL--CEKSFSRAENL 211
            ||..| :.......:.|.|..|.|..:.|.|:||::.|.|.||.|||..|..  |.|.|:|:|||
Mouse   404 VTVEH-VGGPEQSSHVCFWEDCPREGKPFKAKYKLINHIRVHTGEKPFPCPFPGCGKVFARSENL 467

  Fly   212 KIHIRSHSGEKPYKCSFEGCQKAYSNSSDRFKHTRTHSMEKPYMCKVAGCQKRYTDPSSLRKHVK 276
            |||.|:|:||||:||.|:||.:.::|||||.||:..|:.:|||.||:.||.|.||.|||||||:|
Mouse   468 KIHKRTHTGEKPFKCEFDGCDRKFANSSDRKKHSHVHTSDKPYYCKIRGCDKSYTHPSSLRKHMK 532

  Fly   277 TFKHSIHLIASQPLTLPSVPCLLEASSESAFTCLPAASSVESTSSSSS 324
                 ||  ...|   |..|..|..||.......|.:..::.|.|.||
Mouse   533 -----IH--CKSP---PPSPGALGYSSVGTPVGDPLSPVLDPTRSRSS 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sug	NP_610826.1	C2H2 Zn finger	170..190	CDD:275368	8/19 (42%)
		zf-H2C2_2	183..207	CDD:290200	11/25 (44%)
		COG5048	192..>271	CDD:227381	45/80 (56%)
		C2H2 Zn finger	198..218	CDD:275368	12/21 (57%)
		zf-H2C2_2	210..237	CDD:290200	16/26 (62%)
		C2H2 Zn finger	226..248	CDD:275368	11/21 (52%)
		C2H2 Zn finger	256..277	CDD:275368	14/20 (70%)
Zic5	NP_075363.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..171
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	190..223
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	232..251
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	321..349		10/48 (21%)
		COG5048	<388..550	CDD:227381	78/172 (45%)
		C2H2 Zn finger	424..444	CDD:275368	8/19 (42%)
		zf-H2C2_2	437..463	CDD:290200	11/25 (44%)
		C2H2 Zn finger	452..474	CDD:275368	12/21 (57%)
		zf-H2C2_2	466..493	CDD:290200	16/26 (62%)
		C2H2 Zn finger	482..504	CDD:275368	11/21 (52%)
		zf-C2H2	510..534	CDD:278523	16/28 (57%)
		C2H2 Zn finger	512..534	CDD:275368	15/26 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	531..573		14/50 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	590..622
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X217
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910