DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sug and zic2

DIOPT Version :9

Sequence 1:	NP_610826.1	Gene:	sug / 36424	FlyBaseID:	FBgn0033782	Length:	384	Species:	Drosophila melanogaster
Sequence 2:	NP_001017025.2	Gene:	zic2 / 549779	XenbaseID:	XB-GENE-482654	Length:	501	Species:	Xenopus tropicalis

Alignment Length:	376	Identity:	115/376 - (30%)
Similarity:	157/376 - (41%)	Gaps:	99/376 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 SGPHSRGIYEPPLGYFTPYNTPPYIAAYSDSGSWLADHHQHHQQQHQQHQQQMQHIRFPTPPITP 75
            :|....|::.||.|.                   |..|..|||..|.:|.|  .||.||
Frog   148 AGGGQHGLFGPPAGS-------------------LHHHPHHHQLSHGEHPQ--GHILFP------ 185

  Fly    76 PRPIAGYGYRQRTQSVIMKARGQQDELCRSPVEFPDDSKSCSSSSECG---TAS----------- 126
                   |...:..:....|.|.|..|......|....:....||..|   ||:
Frog   186 -------GIHDQHAAASQNALGGQMRLGLPGEMFGRTEQYRQVSSPRGDPYTAAQLHNQYAPMNM 243

  Fly   127 ------------------------------DFVCNWTD----------CDRVFDTLDALAQHVTQ 151
                                          :.:|.|.|          |::.|.|:..|..||:.
Frog   244 GMNMAAHHHHHHHHHPGAFFRYMRQQCIKQELICKWIDPEQLSNPKKSCNKTFSTMHELVTHVSV 308

  Fly   152 RHAIASLTDGLYYCRWRGCQRSERGFNARYKMLVHTRTHTKEKPHRCHL--CEKSFSRAENLKIH 214
            .| :.......:.|.|..|.|..:.|.|:||::.|.|.||.|||..|..  |.|.|:|:||||||
Frog   309 EH-VGGPEQSNHICFWEECSREGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIH 372

  Fly   215 IRSHSGEKPYKCSFEGCQKAYSNSSDRFKHTRTHSMEKPYMCKVAGCQKRYTDPSSLRKHVKTFK 279
            .|:|:||||::|.||||.:.::|||||.||...|:.:|||:||:  |.|.||.|||||||:|..:
Frog   373 KRTHTGEKPFQCEFEGCDRRFANSSDRKKHMHVHTSDKPYLCKM--CDKSYTHPSSLRKHMKVHE 435

  Fly   280 HSIHLIASQPLT-----LPSVPCLLEASSESAFTCL-PAASSVESTSSSSS 324
            .|.....|.|..     ..:.|.|:..:||:....| |||::|.:..|.||
Frog   436 SSPQGSESSPAASSGYESSTPPGLVSPNSETQNPNLSPAAAAVSAVHSVSS 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sug	NP_610826.1	C2H2 Zn finger	170..190	CDD:275368	8/19 (42%)
		zf-H2C2_2	183..207	CDD:290200	11/25 (44%)
		COG5048	192..>271	CDD:227381	44/80 (55%)
		C2H2 Zn finger	198..218	CDD:275368	12/21 (57%)
		zf-H2C2_2	210..237	CDD:290200	16/26 (62%)
		C2H2 Zn finger	226..248	CDD:275368	12/21 (57%)
		C2H2 Zn finger	256..277	CDD:275368	13/20 (65%)
zic2	NP_001017025.2	zf_ZIC	269..314	CDD:375792	10/45 (22%)
		COG5048	<284..438	CDD:227381	69/156 (44%)
		C2H2 Zn finger	324..346	CDD:275368	8/21 (38%)
		C2H2 Zn finger	354..376	CDD:275368	12/21 (57%)
		C2H2 Zn finger	384..406	CDD:275368	12/21 (57%)
		C2H2 Zn finger	414..434	CDD:275368	14/21 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X217
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910